Abstract：
:Free radical processes are proposed to play a crucial role in the development of procainamide adverse effects. Therefore, selenium, as a potent antioxidant, may modified procainamide toxicity. To test this hypothesis plasma and liver thiobarbituric acid-reacting substances (TBARS), plasma antioxidant activity (AOA), erythrocyte and liver superoxide dismutase (SOD), catalase, as well as selenium-dependent glutathione peroxidase (Se-GPX) were determined in the following four groups of rats: selenium-treated (Se), procainamide-treated (P), procainamide and selenium-treated (P + Se), and control (C). Morphological studies of leukocytes [tested for lupus erythematosus (LE) cells] and liver were also made. Atypical, i.e. enlarged and swollen, leukocytes resulting from procainamide and selenium treatment were observed. These changes were found in four out of five rats in the Se group, eight out of ten in the P group, and in seven out of ten in the P + Se group. LE-like cells were observed in two rats in the P + Se group. A statistically significant decrease in plasma and liver TBARS by 20% and 36%, respectively, increased activity of SOD by 20%, catalase by 48% and Se-GPX by 15% in erythrocytes, and decreased activity of liver SOD by 17% and catalase by 22% were found in the P + Se group as compared to the P group. These results indicated that selenium exerted antioxidant effects on the procainamide-treated rats. However, selenium did not prevent the development of disturbances in leukocyte morphology, on the contrary, it possibly promoted the conversion of leukocytes to LE cells.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Toborek M,Magner-Wróbel K,Drózdz M,Danch A,Kopieczna-Grzebieniak Edoi
10.1007/BF01973693subject
Has Abstractpub_date
1993-01-01 00:00:00pages
691-5issue
10eissn
0340-5761issn
1432-0738journal_volume
67pub_type
杂志文章abstract：:This discussion of the NEL presents some thoughts how toxicologists could be encouraged to use more sophisticated modern techniques for the study of various environmental chemicals. It is proposed to use the concept of the NEL only for data obtained by conventional techniques in routine toxicity experiments. Informati...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00695868
更新日期：1979-10-01 00:00:00
abstract：:The nephrotoxicity of 4-amino-3-S-glutathionylphenol (PAP-GSH), a known metabolite of 4-amino-phenol (PAP), was determined in male Fischer 344 rats. Administration of a single dose of 40 or 60 mumol kg-1 caused a marked elevation in blood urea nitrogen and an increase in the urinary excretion of glucose, protein and g...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF03035706
更新日期：1994-01-01 00:00:00
abstract：:During/after the BP/Deepwater Horizon oil spill, cleanup workers, fisherpersons, SCUBA divers, and coastal residents were exposed to crude oil and dispersants. These people experienced acute physiological and behavioral symptoms and consulted a physician. They were diagnosed with petroleum hydrocarbon poisoning and ha...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1526-5
更新日期：2016-04-01 00:00:00
abstract：:Drug-induced liver injuries have been a major focus of current research in drug development, and are also one of the major reasons for the failure and withdrawal of drugs in development. Drug-induced liver injuries have been systematically recorded in many public databases, which have become valuable resources in this...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-017-2024-8
更新日期：2017-09-01 00:00:00
abstract：:Primary human hepatocytes (hHeps) are still gold standard to perform human drug metabolism studies, but their availability is limited by donor organ scarcity. Therefore, hepatoma cell lines are widely used as alternatives, although their phases I and II drug-metabolizing activities are substantially lower compared wit...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0733-y
更新日期：2012-01-01 00:00:00
abstract：:DNA binding in vivo: [6,7-3H]beta-trenbolone (beta-TBOH) was administered p.o. and i.p. to rats. After 8 or 16 h, DNA was isolated from the livers and purified to constant specific radioactivity. Enzymatic digestion to deoxyribonucleotides and separation by HPLC revealed about 90% of the DNA radioactivity eluting in t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00570127
更新日期：1988-01-01 00:00:00
abstract：:Perfluorooctanoic acid (PFOA) has been shown to cause hepatotoxicity and other toxicological effects. Though PPARα activation by PFOA in the liver has been well accepted as an important mechanism of PFOA-induced hepatotoxicity, several pieces of evidence have shown that the hepatotoxic effects of PFOA may not be fully...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1675-1
更新日期：2017-01-01 00:00:00
abstract：:DW-116, 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-l-piperazinyl)-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid hydrochloride, is a newly developed fluoroquinolone antibacterial. The potential of DW-116 to induce developmental toxicity was, investigated in Sprague-Dawley rats. DW-116 was administered by gavage to pre...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050662
更新日期：2000-04-01 00:00:00
abstract：:In the present study the toxicological potential of a tumor-inhibiting dinuclear platinum(II) complex (bis(acetato)diammine-bis-micro-acetato diplatinum(II) dihydrate (BAP)) was evaluated, utilizing in vitro models of nephrotoxicity, myelosuppression and neurotoxicity. Regarding the discrepancies between the hallmark ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0078-0
更新日期：2006-09-01 00:00:00
abstract：:Morphological changes in mitochondria are observed early in the course of acetaminophen (AA)-induced hepatotoxicity, and mitochondrial dysfunction has been observed both in vivo and in vitro following exposure to AA. This study examined the early effects of AA exposure in vivo on mitochondrial respiration and evaluate...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050043
更新日期：1994-01-01 00:00:00
abstract：:Sertoli cells play a critical role in spermatogenesis, and in adults, they are terminally differentiated with loss of proliferative activity. This study revealed Sertoli cell proliferation in 17-week-old Sprague-Dawley rats whose dams had been intragastrically administered 250 ng of 3,3',4,4',5-pentachlorobiphenyl/kg ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0736-8
更新日期：2012-01-01 00:00:00
abstract：:The neurotoxicity of "ecstasy" (3,4-methylenedioxymethamphetamine, MDMA) is thought to involve hepatic metabolism, though its real contribution is not completely understood. Most in vitro neurotoxicity studies concern isolated exposures of MDMA or its metabolites, at high concentrations, not considering their mixture,...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1120-7
更新日期：2014-02-01 00:00:00
abstract：:Menadione is a naphthoquinone used as a vitamin K source in animal feed that can generate reactive oxygen species (ROS) and cause apoptosis. Here, we examined whether menadione reduces development of preimplantation bovine embryos in a ROS-dependent process and tested the hypothesis that actions of menadione would be ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-009-0458-3
更新日期：2009-11-01 00:00:00
abstract：:Exposure to bisphenolic chemicals during pregnancy occurs in > 90% of pregnancies. Bisphenolic compounds can cross the placental barrier reaching fetal circulation. However, the effects of emerging bisphenolic compounds, such as bisphenol S (BPS), on placental function remain untested. The aim was to determine if bisp...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2191-2
更新日期：2018-05-01 00:00:00
abstract：:Bisphenol A (BPA) is a chemical in widespread use that is under scientific discussion due to its endocrine activity. Controversies exist about how to interpret reportedly high blood concentrations measured in uncontrolled situations. Physiologically based pharmaco-/toxicokinetic modelling resulted in 10-100-fold lower...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1022-8
更新日期：2013-07-01 00:00:00
abstract：:Forty-eight hours after a single dose of 14C-imipramine to rats, 14C-radioactivity could be measured in the following organs: liver greater than kidney greater than serum greater than fat greater than spleen greater than duodenum greater than lung greater than muscle and brain. Liver microsomes contained the main part...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00353357
更新日期：1976-12-23 00:00:00
abstract：:Vitamin E acetate (VEA) has come under significant scrutiny due to its association with e-cigarette, or vaping, product use-associated lung injury (EVALI). In 1965, Sir Austin Bradford Hill proposed a set of criteria used to critically assess an association for causality. In this article, we apply the Bradford Hill ca...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-020-02770-x
更新日期：2020-06-01 00:00:00
abstract：:Experimental manganese lymphadenopathy was produced by guinea pigs by intratracheal inoculation of manganese dioxide (50 mg/300 g body weight) and histopathologic changes in the tracheobronchial lymph nodes were studied up to 180 days. There was slow extracellular transport of manganese dust into the nodes, which did ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00351975
更新日期：1976-10-28 00:00:00
abstract：:Aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, has been studied extensively in carcinogenesis through the genomic pathway. In recent years, AHR has also been reported to exert positive or negative effects on epithelial-mesenchymal transition (EMT), the crucial step in tumor malignant progres...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1870-0
更新日期：2017-05-01 00:00:00
abstract：:In a previous study, we showed that bisphenol A (BPA) had oestrogen-like effects in bird embryos, causing malformations of the oviducts in Japanese quail (Coturnix japonica) and feminisation of the left testis in chicken (Gallus domesticus). In this study, uptake and distribution of BPA and tetrabromobisphenol A (TBBP...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040100277
更新日期：2001-12-01 00:00:00
abstract：:Several studies have explored the negative effects of cigarette smoke on bone healing; however, the complex pathogenesis still remains unclear. One crucial and primary factor determining effective fracture repair is the recruitment and differentiation of mesenchymal stem cells (MSCs) into bone-forming cells. Recently,...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2149-9
更新日期：2018-04-01 00:00:00
abstract：:3-Chloro-1,2-propanediol (3-MCPD) fatty acid esters are formed upon thermal processing of fat-containing foods in the presence of chloride ions. Upon hydrolytic cleavage, these substances could release free 3-MCPD. This compound is toxicologically well characterised and displayed cancerogenic potential in rodent model...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0657-6
更新日期：2011-10-01 00:00:00
abstract：:Effects of the oxime HI-6, unrelated to reactivation of acetylcholinesterase (AChE), on field potentials in the dentate gyrus of the rat hippocampus following AChE inhibition, were investigated both in vitro and in vivo. In hippocampal slices, AChE inhibition decreased the perforant path evoked population spike amplit...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050146
更新日期：1994-01-01 00:00:00
abstract：:Knowledge about established breast carcinogens can support improved and modernized toxicological testing methods by identifying key mechanistic events. Ionizing radiation (IR) increases the risk of breast cancer, especially for women and for exposure at younger ages, and evidence overall supports a linear dose-respons...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-020-02752-z
更新日期：2020-05-01 00:00:00
abstract：:The kinetics of vitamin E was followed in serum, liver and kidney of 10- and 55-day-old rats after the administration of a single i.m. dose of 100 mg alpha-tocopherol acetate/100 g body wt. The basal levels without vitamin E administration were significantly higher in serum and liver of 10- than 55-day-old rats. The e...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050444
更新日期：1997-01-01 00:00:00
abstract：:The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized phenethylamine-type NPS that acts as a 5-hydroxyindoleacetic acid (5-HT) receptor agonist, but little is known about its pharmacological effects...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02740-3
更新日期：2020-07-01 00:00:00
abstract：:The cardiovascular effects were investigated after acute and subacute treatment with chlorodibromomethane (CDBM; 0.4 to 3.2 mmol/kg p.o.), trichloromethane (TCM; 0.31 and 1.25 mmol/kg p.o.) and mixtures of CDBM and TCM (acute, 0.8 mmol CDBM/kg + 1.25 mmol TCM/kg p.o.; subacute, 0.4 mmol CDBM/kg + 0.31 mmol TCM/kg p.o....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050459
更新日期：1997-01-01 00:00:00
abstract：:Deoxynivalenol (DON) contamination in food is a public health concern; however, the effect of DON exposure on immune disorders including allergies remains unclear. The aim of this study is to elucidate the effect of oral exposure to DON on pro-inflammatory and pro-pruritic responses in a mouse model of allergic dermat...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02875-3
更新日期：2020-12-01 00:00:00
abstract：:The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-015-1490-0
更新日期：2016-04-01 00:00:00
abstract：:Arsenic has been a recognized contaminant and toxicant, as well as a medicinal compound throughout human history. Populations throughout the world are exposed to arsenic and these exposures have been associated with a number of human cancers. Not much is known about the role of arsenic as a human carcinogen and more r...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-010-0554-4
更新日期：2010-08-01 00:00:00
