Abstract：
:The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in p.Pro206Pro showed significantly higher urinary monomethylarsonic acid (MMA(V)) and lower dimethylarsinic acid (DMA(V))/MMA(V) ratio than genotype AG. As for p.Arg399Gln, both Arg/Arg homozygous subjects and Arg/Gln heterozygous individuals showed a significantly higher urinary inorganic As percentage and lower 8-OHdG concentrations than Gln/Gln homozygous. Our results suggested that Arg399Gln is a functional SNP that may be related to DNA repair activity.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Fujihara J,Yasuda T,Iwata H,Tanabe S,Takeshita Hdoi
10.1007/s00204-015-1490-0subject
Has Abstractpub_date
2016-04-01 00:00:00pages
1009-12issue
4eissn
0340-5761issn
1432-0738pii
10.1007/s00204-015-1490-0journal_volume
90pub_type
杂志文章abstract：:Sunitinib (SNT) is a multi-targeted receptor tyrosine kinase inhibitor that has been approved by the FDA for cancer therapy. However, its cardiotoxicity has limited the clinical applicability with no effective therapeutic approach available. As a broadband kinase inhibitor, the function of several kinases that are ess...
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abstract：:To clarify whether oxidative stress is involved in the development of hepatocellular preneoplastic foci induced by fenofibrate (FF), a peroxisome proliferator-activated receptor alpha agonist, male F344/N rats were fed a diet containing 6,000, 3,000, or 0 ppm of FF for 13 weeks after N-diethylnitrosamine initiation. T...
journal_title：Archives of toxicology
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-010-0633-6
更新日期：2011-09-01 00:00:00
abstract：:This is with reference to the note of the Editor-in-Chief of the Archives of Toxicology. ...
journal_title：Archives of toxicology
pub_type： 杂志文章,已发布勘误
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更新日期：2018-07-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00316323
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abstract：:The neurotoxicity of "ecstasy" (3,4-methylenedioxymethamphetamine, MDMA) is thought to involve hepatic metabolism, though its real contribution is not completely understood. Most in vitro neurotoxicity studies concern isolated exposures of MDMA or its metabolites, at high concentrations, not considering their mixture,...
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pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1007/BF00361248
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journal_title：Archives of toxicology
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s00204-003-0514-3
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Archives of toxicology
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abstract：:In the isolated liver transient perfusion without calcium results in cholestasis which was characterized by an increased efflux rate across the sinusoidal membrane and inhibition of the concentrative transport of bromosulfophthalein to the canalicular side of the cell. Cholestasis could not be reversed within the usua...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00303180
更新日期：1980-03-01 00:00:00
abstract：:The reversibility of quinolone-induced cartilage lesions has not been studied in detail. We treated five groups of five to seven juvenile Wistar rats (male and female; age: 5 weeks) with 2 x 600 mg ofloxacin/kg by gastric intubation on 1 day only (9:00 a.m. and 5:00 p.m.) and studied the knee joints histologically 3 d...
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abstract：: ...
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pub_type： 评论,信件
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更新日期：2018-11-01 00:00:00
abstract：:Iron (Fe) plays essential roles in biological processes, whereas cadmium (Cd) is a toxic and non-essential metal. Two metal transporters, divalent metal transporter 1 (DMT1) and metal transporter protein 1 (MTP1), are responsible for Fe transport in mammals. Here, we studied the effect of dietary Fe on the expression ...
journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：2007-05-01 00:00:00
abstract：:Adverse outcome pathways (AOPs) have been recently introduced as tools to map the mechanisms underlying toxic events relevant for chemical risk assessment. AOPs particularly depict the linkage between a molecular initiating event and an adverse outcome through a number of intermediate key events. An AOP has been previ...
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pub_type： 杂志文章
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journal_title：Archives of toxicology
pub_type： 杂志文章
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journal_title：Archives of toxicology
pub_type： 临床试验,杂志文章,随机对照试验
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abstract：:The aim was to study the long-term response in the olfactory mucosa of NMRI mice after exposure to the olfactory toxicants dichlobenil (a herbicide) or methimazole (an antithyroid drug). Three and six months after exposure to dichlobenil (2x or 1 x 25 mg/kg i.p.), the dorsomedial part of the olfactory region showed a ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-002-0321-2
更新日期：2002-03-01 00:00:00
