Abstract：
:Evading apoptosis and chemo-resistance are considered as very important factors which help tumour progression and metastasis. Hence, to overcome chemo-resistance, there is an urgent requirement for emergence of more effective treatment options. Myricetin, a naturally occurring flavonoid, is present in various plant-derived foods and shows antitumour potential in different cancers. In the present in vitro study, results from the comet assay demonstrated that myricetin bulk (10 µM) and nano (20 µM) forms exhibited a non-significant level of genotoxicity in lymphocytes from multiple myeloma patients when compared to those from healthy individuals. Western blot results showed a decrease in Bcl-2/Bax ratio and an increase in P53 protein levels in lymphocytes from myeloma patients, but not in lymphocytes from healthy individuals. A significant increase in intracellular reactive oxygen species level was also observed, suggesting that regulation of apoptotic proteins triggered by myricetin exposure in lymphocytes from myeloma patients occurred through P53 and oxidative stress-dependent pathways. The potency of myricetin against lymphocytes from myeloma patients marks it a potential candidate to be considered as an alternative to overcome chemo-resistance in cancer therapies.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Akhtar S,Najafzadeh M,Isreb M,Newton L,Gopalan RC,Anderson Ddoi
10.1007/s00204-020-02938-5subject
Has Abstractpub_date
2021-01-01 00:00:00pages
337-343issue
1eissn
0340-5761issn
1432-0738pii
10.1007/s00204-020-02938-5journal_volume
95pub_type
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