Abstract:
:Carbon tetrachloride-induced liver injury is a thoroughly studied model for regeneration and fibrosis in rodents. Nevertheless, its pattern of liver fibrosis is frequently misinterpreted as portal type. To clarify this, we show that collagen type IV+ "streets" and α-SMA+ cells accumulate pericentrally and extend to neighbouring central areas of the liver lobule, forming a 'pseudolobule'. Blood vessels in the center of such pseudolobules are portal veins as indicated by the presence of bile duct cells (CK19+) and the absence of pericentral hepatocytes (glutamine synthetase+). It is critical to correctly describe this pattern of fibrosis, particulary for metabolic zonation studies.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Hammad S,Braeuning A,Meyer C,Mohamed FEZA,Hengstler JG,Dooley Sdoi
10.1007/s00204-017-2040-8subject
Has Abstractpub_date
2017-11-01 00:00:00pages
3689-3692issue
11eissn
0340-5761issn
1432-0738pii
10.1007/s00204-017-2040-8journal_volume
91pub_type
杂志文章abstract::Sulfur mustard (SM) is a highly toxic war chemical that causes significant morbidity and mortality and lacks any effective therapy. Rats exposed to aerosolized CEES (2-chloroethyl ethyl sulfide; 10% in ethanol), an analog of SM, developed acute respiratory distress syndrome (ARDS), which is characterized by increased ...
journal_title:Archives of toxicology
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
pub_type: 杂志文章
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF03035706
更新日期:1994-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1693-z
更新日期:2017-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
pub_type: 杂志文章
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journal_title:Archives of toxicology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s002040050581
更新日期:1999-02-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 信件
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更新日期:1994-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-001-0301-y
更新日期:2002-02-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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journal_title:Archives of toxicology
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更新日期:2017-06-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:1979-10-01 00:00:00
abstract::Whether pregnancy-induced immunosuppression when combined with exposure to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) could exacerbate immunotoxicity has not been previously investigated. The current study evaluated the immune status of C57BL/6 pregnant and virgin mice following exposure to TCDD. To this end, syngene...
journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
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journal_title:Archives of toxicology
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journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/BF00316249
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journal_title:Archives of toxicology
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更新日期:2009-07-01 00:00:00
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journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:2016-04-01 00:00:00
abstract::Clark 1 (diphenylarsine chloride) and Clark 2 (diphenylarsine cyanide) were used as chemical weapon agents (CWA), and the soil contamination by these CWA and their degraded products, diphenyl and phenyl arsenicals, has been one of the most serious environmental issues. In a series of comparisons in toxicity between tr...
journal_title:Archives of toxicology
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Archives of toxicology
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doi:10.1007/BF00324554
更新日期:1987-01-01 00:00:00
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journal_title:Archives of toxicology
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更新日期:2013-04-01 00:00:00