Abstract：
:In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose-response for radiation-induced germ cell mutations was linear and that there was "no escape from the conclusion that there is no threshold". However, assessment of correspondence between Muller and Curt Stern 1 month prior to his Nobel Prize Lecture reveals that Muller knew the results and implications of a recently completed study at the University of Rochester under the direction of Stern, which directly contradicted his Nobel Prize Lecture. This finding is of historical importance since Muller's Nobel Lecture gained considerable international attention and is a turning point in the acceptance of the linearity model in risk assessment for germ cell mutations and carcinogens.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Calabrese EJdoi
10.1007/s00204-011-0728-8subject
Has Abstractpub_date
2011-12-01 00:00:00pages
1495-8issue
12eissn
0340-5761issn
1432-0738journal_volume
85pub_type
历史文章,杂志文章abstract：:Monolayers of L6 rat skeletal myoblast cells formed surface binding isotherms with the purified tobacco leaf glycoprotein TGP1 and the enriched cigarette tar glycoprotein TGP2. Scatchard analysis showed that the binding in the range of the limited concentrations tested was to a single class molecule and the calculated...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050151
更新日期：1995-01-01 00:00:00
abstract：:The cytotoxicity of trivalent and pentavalent inorganic arsenic salts was determined in mouse fibroblasts in vitro. Concentrations of As (III) in the microM range led to a reduction of proliferation and viability with a concomitant increase in LDH release and stimulation of lactic acid production. Similar effects were...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00290882
更新日期：1985-08-01 00:00:00
abstract：UNLABELLED:An overdose of acetaminophen (APAP) causes hepatotoxicity due to its metabolite, N-acetyl-p-benzoquinone imine. NAD(P)H:quinone oxidoreductase 1 (NQO1) is an important enzyme for detoxification, because it catabolizes endogenous/exogenous quinone to hydroquinone. Although various studies have suggested the ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1340-5
更新日期：2015-11-01 00:00:00
abstract：:Several structurally different metal chelating agents were screened for their relative efficacy in counteracting acute manganese intoxication in mice. Polyaminocarboxylic acids with nitrogen and oxygen as metal binding sites were more effective than certain sulfhydryl chelating agents and common drugs in preventing mo...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00569233
更新日期：1982-05-01 00:00:00
abstract：:In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca2+ homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca2+-binding proteins and/or Ca2+ pumps. The plasma membrane calcium pump (PMCA) maintains Ca2+ homeosta...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-2031-9
更新日期：2018-01-01 00:00:00
abstract：:The studies presented were designed to investigate the effects of cytochrome P450 inhibition on tetrahydrofuran-induced hepatocellular proliferation in female B6C3F(1) mice. Groups of female B6C3F(1) mice were exposed to dynamic atmospheres containing tetrahydrofuran (THF) concentrations of 0, 5,400 or 15,000 mg/m(3) ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0474-7
更新日期：2003-08-01 00:00:00
abstract：:The lacrimatory agent CS was examined for genotoxic properties. In vitro, Salmonella typhimurium was exposed to CS at concentrations up to 1.5 mg per plate and reverse mutations were assayed. In vivo: male Drosophilae were fed with CS and sex-linked recessive lethal mutations in sperm cells were assayed using the Basc...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01261386
更新日期：1983-10-01 00:00:00
abstract：:Breast cancer is the most commonly diagnosed malignancy in females, the etiology being multifactorial and includes the role of lifestyle exposure to DNA-damaging chemicals such as dietary carcinogens benzo (a) pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP). Both compounds require cytochrome...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02558-8
更新日期：2019-10-01 00:00:00
abstract：:Nephrotoxicity is a major side effect of cisplatin in chemotherapy. Pathologically, cisplatin nephrotoxicity is characterized by cell injury and death in renal tubules. The research in the past decade has gained significant understanding of the cellular and molecular mechanisms of tubular cell death, revealing a centr...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-014-1239-1
更新日期：2014-06-01 00:00:00
abstract：:The highly directional maternal-to-fetal transfer of essential fatty acids (EFAs) across the placenta plays a critical role in guiding proper fetal development. Exposure to xenobiotics that may alter the fetal supply of EFAs/lipids could lead to fetal toxicity. Since the placenta is the first fetal arising organ that ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0047-z
更新日期：2006-05-01 00:00:00
abstract：:A wide variety of immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in experimental animals has been documented. In contrast, the impact of dioxin on the human immune system remains controversial, although adverse health effects have been reported in humans after occupational or accidental exposu...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050072
更新日期：1994-01-01 00:00:00
abstract：:The development and application of high throughput in vitro assays is an important development for risk assessment in the twenty-first century. However, there are still significant challenges to incorporate in vitro assays into routine toxicity testing practices. In this paper, a robust learning approach was developed...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2260-6
更新日期：2018-09-01 00:00:00
abstract：:Boric acid and sodium borates are currently classified as being toxic to reproduction under "Category 1B" with the hazard statement of "H360 FD" in the European CLP regulation. This has prompted studies on boron-mediated reprotoxic effects in male workers in boron mining areas and boric acid production plants. By cont...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2238-4
更新日期：2018-08-01 00:00:00
abstract：:UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe substrates (14) for various UGT isofo...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02765-8
更新日期：2020-08-01 00:00:00
abstract：:Arsenic has been a recognized contaminant and toxicant, as well as a medicinal compound throughout human history. Populations throughout the world are exposed to arsenic and these exposures have been associated with a number of human cancers. Not much is known about the role of arsenic as a human carcinogen and more r...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-010-0554-4
更新日期：2010-08-01 00:00:00
abstract：:Etridiazole, 5-ethoxy-3-trichloromethyl-1,2,4-thiadiazole, was orally administered to rats and human volunteers. Two metabolites of etridiazole were synthesized: 5-ethoxy-1,2,4-thiadiazole-3-carboxylic acid (ET-CA) and N-acetyl-S-(5-ethoxy-1,2,4-thiadiazol-3-yl-methyl)-L-cysteine (ET-MA). Selective and sensitive analy...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF02098027
更新日期：1991-01-01 00:00:00
abstract：:Garenoxacin is a des-F(6)-quinolone with a broad antibacterial spectrum, which has previously been shown to exhibit low chondrotoxicity in juvenile dogs compared with several other quinolones. A study was performed to determine whether the low chondrotoxicity observed in immature rats following garenoxacin treatment c...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0514-3
更新日期：2004-02-01 00:00:00
abstract：:Male F344/DuCrj (Fischer) rats were given bisphenol A (BPA) in the diet at levels of 0 (control), 0.25, 0.50 and 1.00%, equivalent to 0, 235, 466 and 950 mg/kg per day, respectively, for 44 days. Body weight gains were depressed dose-dependently in BPA-treated rats, and those of 0.50 and 1.00% groups were significant....
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000204
更新日期：2001-03-01 00:00:00
abstract：:Neurotoxic properties of acrylamide and seven related compounds in rats were studied with regard to the effects on rotarod performance, morphology of nerves and neurotubulin. Compounds used in the present study were acrylamide, N-hydroxymethylacrylamide, N-isopropylacrylamide, methacrylamide, N-methylacrylamide, croto...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01239204
更新日期：1983-11-01 00:00:00
abstract：:The possible formation of singlet oxygen via photoexcited psoralens has been associated with the occurrence of, amongst others, erythema. Therefore it has been suggested to combine PUVA with the topical or systemic administration of antioxidants. However, the effect of these antioxidants on the photobinding of psorale...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01977362
更新日期：1991-01-01 00:00:00
abstract：:Some nucleoside analogues are used to treat herpes simplex and other viral infections. They are known to impair spermatogenesis, but published data are scarce. We studied the effects of four nucleosides on SerW3 cells, a rat Sertoli cell line. Cells were cultured for 3 days in DMEM supplemented with four different con...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1743-6
更新日期：2016-08-01 00:00:00
abstract：:Natural and synthetic chemicals are often used in the fragrance industry. A toxicological profile of the synthetic fragrance booster, 4-cycloocten-1-carbaldehyde, was generated using a test program including the following methods: acute oral toxicity, acute dermal toxicity, acute skin and eye irritation, skin sensitiz...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0596-6
更新日期：2004-12-01 00:00:00
abstract：:The ability of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC), 3,5-diethoxycarbonyl-4-ethyl-1,4-dihydro-2,6-dimethylpyridine (EDDC) and griseofulvin to induce porphyria in primary cultures of mouse hepatocytes has been examined. Exposure of cultured mouse hepatocytes to DDC, EDDC or griseofulvin resulted in a marked ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01974011
更新日期：1992-01-01 00:00:00
abstract：:A set of biomedically relevant iron oxide nanoparticles with systematically modified polymer surfaces was investigated regarding their interaction with the first contact partners after systemic administration such as blood cells, blood proteins, and the endothelial blood vessels, to establish structure-activity relati...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-017-1968-z
更新日期：2017-10-01 00:00:00
abstract：:The effect of lindane and heptachlor on haem metabolism was studied with the aim to elucidate the mechanism of their porphyrinogenic action. The effects of these compounds on delta-aminolaevulinate synthase (ALA-S) and ferrochelatase were evaluated and the mechanism of increase of ALA-S activity was especially studied...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050566
更新日期：1998-11-01 00:00:00
abstract：:This study investigated whether paraquat (Pq)-induced lipidic peroxidation (LP) is accompanied by changes in blood pressure and heart rate (HR) in rats. Groups of adult male Wistar rats were studied 2 and 12 h after Pq (35 mg/kg, i.p.) administration. The LP was evaluated by monitoring thiobarbituric acid reactive sub...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-005-0660-x
更新日期：2005-09-01 00:00:00
abstract：:Regarding the potential impact of traffic-born air pollutants on public health, in recent years attention has increasingly been focused on the possible effects on the cardiovascular system. In order to investigate this problem further, the influence of long-term exhaust gas exposure on rats has been studied. One hundr...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332390
更新日期：1981-07-01 00:00:00
abstract：:The pharmacokinetics of styrene were investigated in male Sprague-Dawley rats and male B6C3F1 mice using the closed chamber technique. Animals were exposed to styrene vapors of initial concentrations ranging from 550 to 5000 ppm, or received intraperitoneal (i.p.) doses of styrene from 20 to 340 mg/kg or oral (p.o.) d...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01969264
更新日期：1993-01-01 00:00:00
abstract：:3H-soman (specific activity 10 Ci/mMol), a potent irreversible cholinesterase inhibitor, was administered IV to mice in a dose of one LD-50, which corresponds to 0.25 mCi/mouse. Animals were sacrificed at 5 min, 2 h and 24 h, and whole body autoradiography was performed. High levels of radioactivity in lung and skin w...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00292616
更新日期：1985-10-01 00:00:00
abstract：:Dulcin (DL), now banned, was once a widely used artificial sweetener. DL possesses an ureido group that is metabolized by direct glucuronidation in rabbit liver microsomes. Dulcin N-glucuronide (DNG) is the only type of ureido N-glucuronide known to date; ureido glucuronidation in humans has not been previously report...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0138-5
更新日期：2007-03-01 00:00:00
