Inhibition of ferrochelatase and accumulation of porphyrins in mouse hepatocyte cultures exposed to porphyrinogenic chemicals.

abstract：:The investigation was aimed at providing insight into the side chain metabolism of furazolidone in mice. The agents used in the experiments were furazolidone, 3-amino-2-oxazolidinone, oxazolidinone, nitrofurantoin, 3-aminohydantoin and hydantoin, administered intraperitoneally at five equimolar doses ranging from 0.17...

journal_title：Archives of toxicology

authors： Hunder G,Schmid A,Mayring L

更新日期：1987-12-01 00:00:00

abstract：:We recently presented a modified local lymph node test which made it possible to quickly and reliably differentiate between irritative and allergic skin reactions with extremely simple parameters. The Integrated Model for the Differentiation of Skin Reactions (IMDS) test combines measurement of cell proliferation in d...

journal_title：Archives of toxicology

authors： Vohr HW,Blümel J,Blotz A,Homey B,Ahr HJ

更新日期：2000-01-01 00:00:00

abstract：:Conventional in vitro toxicity studies have focused on identifying IC50 and the underlying mechanisms, but how toxicants influence biophysical and biomechanical changes in human cells, especially during developmental stages, remain understudied. Here, using an atomic force microscope, we characterized changes in bioph...

journal_title：Archives of toxicology

authors： Mahajan G,Lee MY,Kothapalli C

更新日期：2019-10-01 00:00:00

abstract：:Dinitrochlorobenzene (DNCB) absorption through mouse and rat dorsal skin, pig ear skin and human abdominal skin in vitro was determined, and local metabolism to the glutathione conjugate was related to glutathione transferase activities and glutathione status in the skin. Absorption studies were conducted using skin m...

journal_title：Archives of toxicology

authors： Jewell C,Heylings J,Clowes HM,Williams FM

更新日期：2000-09-01 00:00:00

abstract：:A compound was isolated from the urine of workers exposed to carbon disulfide during the production of rayon. The compound was identified as 2-thiothiazolidine-4-carboxylic acid (TTCA) by GC/MS and NMR. A HPLC method for the quantitative determination of TTCA was elaborated and applied to urine samples. The method all...

journal_title：Archives of toxicology

authors： van Doorn R,Delbressine LP,Leijdekkers CM,Vertin PG,Henderson PT

更新日期：1981-03-01 00:00:00

abstract：:Metabolism of isobutene (2-methylpropene) in rats (Sprague Dawley) and mice (B6C3F1) follows kinetics according to Michaelis-Menten. The maximal metabolic elimination rates are 340 mumol/kg/h for rats and 560 mumol/kg/h for mice. The atmospheric concentration at which Vmax/2 is reached is 1200 ppm for rats and 1800 pp...

journal_title：Archives of toxicology

authors： Csanády GA,Freise D,Denk B,Filser JG,Cornet M,Rogiers V,Laib RJ

更新日期：1991-01-01 00:00:00

abstract：:Insulin-exposed rat mammary cancer cells were flow sorted based on a c-myc reporter plasmid encoding a destabilized green fluorescent protein. Sorted cells exhibited gradual increases in c-myc levels. Cells overexpressing c-myc by only 10% exhibited phenotypic changes attributable to c-myc overexpression, such as cell...

journal_title：Archives of toxicology

authors： Knudsen KJ,Nelander Holm GM,Krabbe JS,Listov-Saabye N,Kiehr B,Dufva M,Svendsen JE,Oleksiewicz MB

更新日期：2009-12-01 00:00:00

abstract：:Female wistar rats, conventional albino mice, and Chinese hamsters were given a single dose of acrylonitrile, 0.5 or 0.75 mM/kg body weight. The elimination in the urine of thiocyanate, which is the main metabolite of acrylonitrile, indicated a decreasing proportion of biotransformation after oral (over 20%), intraper...

journal_title：Archives of toxicology

authors： Gut I,Nerudová J,Kopecký J,Holecek V

更新日期：1975-02-14 00:00:00

abstract：:The cardiovascular effects were investigated after acute and subacute treatment with chlorodibromomethane (CDBM; 0.4 to 3.2 mmol/kg p.o.), trichloromethane (TCM; 0.31 and 1.25 mmol/kg p.o.) and mixtures of CDBM and TCM (acute, 0.8 mmol CDBM/kg + 1.25 mmol TCM/kg p.o.; subacute, 0.4 mmol CDBM/kg + 0.31 mmol TCM/kg p.o....

journal_title：Archives of toxicology

authors： Müller SP,Wolna P,Wünscher U,Pankow D

更新日期：1997-01-01 00:00:00

abstract：:New strategies are needed to address the data gap between the bioactivity of chemicals in the environment versus existing hazard information. We address whether a high-throughput screening (HTS) system using a vertebrate organism (embryonic zebrafish) can characterize chemical-elicited behavioral responses at an early...

journal_title：Archives of toxicology

authors： Reif DM,Truong L,Mandrell D,Marvel S,Zhang G,Tanguay RL

更新日期：2016-06-01 00:00:00

abstract：:In the recent years, the toxicity of certain divalent cations has been associated with the alteration of intracellular Ca2+ homeostasis. Among other mechanisms, these cations may affect the functionality of certain Ca2+-binding proteins and/or Ca2+ pumps. The plasma membrane calcium pump (PMCA) maintains Ca2+ homeosta...

journal_title：Archives of toxicology

authors： Ferreira-Gomes MS,Mangialavori IC,Ontiveros MQ,Rinaldi DE,Martiarena J,Verstraeten SV,Rossi JPFC

更新日期：2018-01-01 00:00:00

abstract：:DW-116, 1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-l-piperazinyl)-1, 4-dihydro-4-oxoquinolone-3-carboxylic acid hydrochloride, is a newly developed fluoroquinolone antibacterial. The potential of DW-116 to induce developmental toxicity was, investigated in Sprague-Dawley rats. DW-116 was administered by gavage to pre...

journal_title：Archives of toxicology

authors： Kim JC,Yun HI,Shin HC,Han SS,Chung MK

更新日期：2000-04-01 00:00:00

abstract：:Bolesatine, a glycoprotein from Boletus satanas Lenz, has previously been shown to be mitogenic to rat and human lymphocytes at very low concentrations, whereas higher concentrations inhibit protein synthesis in vitro and in several in vivo systems. The mechanism whereby this mitogenic activity occurs was previously u...

journal_title：Archives of toxicology

authors： Ennamany R,Kretz O,Creppy EE

更新日期：1995-01-01 00:00:00

abstract：:A method is outlined to estimate from hemodialysis or hemoperfusion data, respectively, the rate constants, the distribution volume in the beta-phase, and other pharmacokinetic parameters of toxic substances. All calculations are based on the assumption that the usual linear open two-compartment system is also the app...

journal_title：Archives of toxicology

authors： Wellhöner HH

更新日期：1983-05-01 00:00:00

abstract：:Aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor, has been studied extensively in carcinogenesis through the genomic pathway. In recent years, AHR has also been reported to exert positive or negative effects on epithelial-mesenchymal transition (EMT), the crucial step in tumor malignant progres...

journal_title：Archives of toxicology

authors： Li CH,Liu CW,Tsai CH,Peng YJ,Yang YH,Liao PL,Lee CC,Cheng YW,Kang JJ

更新日期：2017-05-01 00:00:00

abstract：:Rats were exposed to nickel sulfate (NiSO4) either by intratracheal (IT) instillation or by acute aerosol inhalation, and pulmonary clearance of Ni and pulmonary inflammatory responses were studied. The half-time of Ni in the lung (initial lung burden = 50 micrograms Ni/rat) was about 32 h in both the IT instillation ...

journal_title：Archives of toxicology

authors： Hirano S,Shimada T,Osugi J,Kodama N,Suzuki KT

更新日期：1994-01-01 00:00:00

abstract：:The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regula...

journal_title：Archives of toxicology

authors： Li F,Zhang J,Arfuso F,Chinnathambi A,Zayed ME,Alharbi SA,Kumar AP,Ahn KS,Sethi G

更新日期：2015-05-01 00:00:00

abstract：:Long-term exposure of rats to cadmium (Cd) resulted in a marked suppression of erythropoietin (Epo) mRNA expression in the kidneys and the development of severe anemia. A recent report revealed that Cd inhibited hypoxia-inducible factor 1 (HIF-1) binding activity and Epo mRNA expression and protein production. However...

journal_title：Archives of toxicology

authors： Obara N,Imagawa S,Nakano Y,Suzuki N,Yamamoto M,Nagasawa T

更新日期：2003-05-01 00:00:00

abstract：:The effects of dicamba, a widely used broad-leaf herbicide, on rat liver mitochondrial bioenergetic activities were examined. The results obtained for state 4 respiration indicate not only an uncoupling effect, the result of an increase on the permeability of inner mitochondria membrane to protons, but also a strong i...

journal_title：Archives of toxicology

authors： Peixoto F,Vicente JA,Madeira VM

更新日期：2003-07-01 00:00:00

abstract：:The effect of various hepatotoxicants on urinary taurine and urinary creatine has been studied in the rat. Several hepatotoxic agents, carbon tetrachloride, thioacetamide, galactosamine and allyl alcohol which all caused hepatic necrosis (sometimes accompanied by steatosis), resulted in a rise in urinary taurine and i...

journal_title：Archives of toxicology

authors： Waterfield CJ,Turton JA,Scales MD,Timbrell JA

更新日期：1993-01-01 00:00:00

abstract：:In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose-response for radiation-induced germ cell mutations was linear and that there was "no escape from the conclusion that there is no threshold". However, assessment of correspondence between Muller and Curt Stern 1 month prior to his N...

journal_title：Archives of toxicology

authors： Calabrese EJ

更新日期：2011-12-01 00:00:00

abstract：:In female rats, the lethality and hepatotoxicity of cerous chloride (CeCl3) were significantly altered by pretreatment with steroidal and nonsteroidal compounds (pregnenolone-16alpha-carbonitrile "PCN", dexamethasone, spironolactone, phenobarbital) that stimulate hepatic drug-metabolizine enzyme activity and by estrad...

journal_title：Archives of toxicology

authors： Salas M,Tuchweber B

更新日期：1976-03-11 00:00:00

abstract：:The pharmacokinetics of styrene were investigated in male Sprague-Dawley rats and male B6C3F1 mice using the closed chamber technique. Animals were exposed to styrene vapors of initial concentrations ranging from 550 to 5000 ppm, or received intraperitoneal (i.p.) doses of styrene from 20 to 340 mg/kg or oral (p.o.) d...

journal_title：Archives of toxicology

authors： Filser JG,Schwegler U,Csanády GA,Greim H,Kreuzer PE,Kessler W

更新日期：1993-01-01 00:00:00

abstract：:Since teratogenicity testing in mammals is a particular challenge from an animal welfare perspective, there is a great need for the development of alternative test systems. In this context, the zebrafish (Danio rerio) embryo has received increasing attention as a non-protected embryonic vertebrate in vivo model. The p...

journal_title：Archives of toxicology

authors： Brotzmann K,Wolterbeek A,Kroese D,Braunbeck T

更新日期：2020-10-27 00:00:00

abstract：:The influence of pivalic acid (PIV), a compound often used to make pro-drugs, and of the structurally related trichloroacetic acid (TCA), on several hepatic and renal enzymes was investigated in Sprague-Dawley rats, following a 4-day treatment period. The PIV and TCA treatments resulted in a similar and selective indu...

journal_title：Archives of toxicology

authors： Zanelli U,Puccini P,Acerbi D,Ventura P,Gervasi PG

更新日期：1996-01-01 00:00:00

abstract：:Nephrotoxicity is a major side effect of cisplatin in chemotherapy. Pathologically, cisplatin nephrotoxicity is characterized by cell injury and death in renal tubules. The research in the past decade has gained significant understanding of the cellular and molecular mechanisms of tubular cell death, revealing a centr...

journal_title：Archives of toxicology

authors： Yang Y,Liu H,Liu F,Dong Z

更新日期：2014-06-01 00:00:00

abstract：:Fifteen patients who were severely poisoned with either hypnotic drugs or salicylate were treated by charcoal haemoperfusion. The device contained 100g of activated charcoal immobilised by fixation to a polyester film. Two patients showed no response and eventually died. The remainder showed marked lightening of coma ...

journal_title：Archives of toxicology

authors： Hampel G,Crome P,Widdop B,Goulding R

更新日期：1980-07-01 00:00:00

abstract：:Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicating factor is that non-genotoxic carcinogens act through several distinctive modes of action, which makes prediction of t...

journal_title：Archives of toxicology

authors： Schaap MM,Wackers PF,Zwart EP,Huijskens I,Jonker MJ,Hendriks G,Breit TM,van Steeg H,van de Water B,Luijten M

更新日期：2015-12-01 00:00:00

abstract：:Primary human hepatocytes (hHeps) are still gold standard to perform human drug metabolism studies, but their availability is limited by donor organ scarcity. Therefore, hepatoma cell lines are widely used as alternatives, although their phases I and II drug-metabolizing activities are substantially lower compared wit...

journal_title：Archives of toxicology

authors： Lin J,Schyschka L,Mühl-Benninghaus R,Neumann J,Hao L,Nussler N,Dooley S,Liu L,Stöckle U,Nussler AK,Ehnert S

更新日期：2012-01-01 00:00:00

abstract：:The binding characteristics of [14C]ortho-toluidine (OT), a suspect human carcinogen, were investigated in male Sprague-Dawley rats. Rats were administered [14C]OT i.p. at 10, 20, 40, 50, or 100 mg/kg body weight, then sacrificed at 2, 4, 8, 18, 24, 48, or 72 h, or 7, 14, or 28 days. Hemoglobin (Hb) and albumin (Alb) ...

journal_title：Archives of toxicology

authors： DeBord DG,Swearengin TF,Cheever KL,Booth-Jones AD,Wissinger LA

更新日期：1992-01-01 00:00:00