Arsenic-containing hydrocarbons: effects on gene expression, epigenetics, and biotransformation in HepG2 cells.

abstract：:Second order rate constants for the initial reaction of 12 mammalian oxyhemoglobins (Hb) with equimolar phenylhydrazine (PHZ), a compound inducing Heinz body hemolytic anemia, were determined by recording continuous changes in absorbance with time at 577 nm. The rate constants were varied in a range from 43 m-1.s-1 wi...

journal_title：Archives of toxicology

authors： Kinuta M,Matteson JL,Itano HA

更新日期：1995-01-01 00:00:00

abstract：:Our previous study suggested the possibilities that dicyclanil (DC), a nongenotoxic carcinogen, produces oxidative stress in the liver of the two-stage hepatocarcinogenesis model of mice and the stress induced probably causes secondary oxidative DNA damage. However, clear evidences demonstrating the relationship betwe...

journal_title：Archives of toxicology

authors： Moto M,Umemura T,Okamura M,Muguruma M,Ito T,Jin M,Kashida Y,Mitsumori K

更新日期：2006-10-01 00:00:00

abstract：:The effects of small repeated oral doses of mono-2-cresyl diphenyl phosphate (MOCP, 2.5 mg/kg/day) on hen brain and spinal cord neurotoxic esterase (NTE) were measured. The enzyme levels were depressed to about 40% and 55% of normal respectively and maintained at that level for 8 weeks. No clinical and only doubtful h...

journal_title：Archives of toxicology

authors： Lotti M,Johnson MK

更新日期：1980-10-01 00:00:00

abstract：: ...

journal_title：Archives of toxicology

authors： Deng Y,Zhang Y

更新日期：2019-01-01 00:00:00

abstract：:Perfluorooctanoic acid (PFOA) has been shown to cause hepatotoxicity and other toxicological effects. Though PPARα activation by PFOA in the liver has been well accepted as an important mechanism of PFOA-induced hepatotoxicity, several pieces of evidence have shown that the hepatotoxic effects of PFOA may not be fully...

journal_title：Archives of toxicology

authors： Yan S,Zhang H,Guo X,Wang J,Dai J

更新日期：2017-01-01 00:00:00

abstract：:We investigated the influence of the dopamine antagonist haloperidol on the neurotransmitter content in the developing rat brain. Dopamine (DA), serotonin (5-HT) and the corresponding metabolites dopac, HVA and HIAA were determined in the corpus striatum of the rat between day 1 and day 21 pn by HPLC with electro-chem...

journal_title：Archives of toxicology

authors： Schwabe R,Thiel R,Chahoud I,Neubert D

更新日期：1992-01-01 00:00:00

abstract：:The US Environmental Protection Agency's ToxCast program has generated toxicity data for thousands of chemicals but does not adequately assess potential neurotoxicity. Networks of neurons grown on microelectrode arrays (MEAs) offer an efficient approach to screen compounds for neuroactivity and distinguish between com...

journal_title：Archives of toxicology

authors： Kosnik MB,Strickland JD,Marvel SW,Wallis DJ,Wallace K,Richard AM,Reif DM,Shafer TJ

更新日期：2020-02-01 00:00:00

abstract：:The effects of equimolar doses of the triphenylethylene antiestrogens tamoxifen and toremifene on female Sprague-Dawley rat liver were studied in a 52-week toxicity study which included a 13-week recovery period. Liver tumors were found in four out of five rats at the highest dose level of tamoxifen (45 mg/kg per day)...

journal_title：Archives of toxicology

authors： Hirsimäki P,Hirsimäki Y,Nieminen L,Payne BJ

更新日期：1993-01-01 00:00:00

abstract：:Thanks to the confluence of genome sequencing and bioinformatics, the number of metabolic databases has expanded from a handful in the mid-1990s to several thousand today. These databases lie within distinct families that have common ancestry and common attributes. The main families are the MetaCyc, KEGG, Reactome, Mo...

journal_title：Archives of toxicology

authors： Karp PD,Caspi R

更新日期：2011-09-01 00:00:00

abstract：:As previously demonstrated, chronic administration of phenobarbital (0.05% in the drinking water) and of nafenopin (0.1% in the diet) increases the incidence and the kinetics of appearance of liver cancers. If bile acids play a key role in liver carcinogenesis, it might thus be expected that treatments like phenobarbi...

journal_title：Archives of toxicology

authors： Delzenne NM,Taper HS,Roberfroid M

更新日期：1994-01-01 00:00:00

abstract：:Pulmonary fibrosis is a poorly understood pathologic condition. Carbon nanotubes (CNTs) are nanomaterials with potentials for broad applications. CNTs can induce pulmonary fibrosis in animals, a cause for concern for exposed workers and consumers. Given the large number of CNTs available on the market and the seemingl...

journal_title：Archives of toxicology

authors： Hindman B,Ma Q

更新日期：2018-11-01 00:00:00

abstract：:Garenoxacin is a des-F(6)-quinolone with a broad antibacterial spectrum, which has previously been shown to exhibit low chondrotoxicity in juvenile dogs compared with several other quinolones. A study was performed to determine whether the low chondrotoxicity observed in immature rats following garenoxacin treatment c...

journal_title：Archives of toxicology

authors： Kastner M,Rahm U,Baumann-Wilschke I,Bello A,Stahlmann R

更新日期：2004-02-01 00:00:00

abstract：:The antidepressants, imipramine and mianserin, have been reported to cause liver damage. We investigated a role of cytochrome P450 (CYP)-mediated formation of a reactive metabolite in antidepressant-induced acute cell injury using hepatocytes isolated from male and female Wistar rats, and male Dark Agouti rats, which ...

journal_title：Archives of toxicology

authors： Masubuchi Y,Konishi M,Horie T

更新日期：1999-04-01 00:00:00

abstract：:The inhibitory effect and mechanism of action of nicotinamide to paraquat toxicity were studied in male Sprague-Dawley rats. Proteins of submitochondrial particles (SMP), especially of mol. wt. 25-30 kDa, in rat lungs were destroyed by paraquat radicals, and aggregated protein bands approximately 100 kDa were observed...

journal_title：Archives of toxicology

authors： Fukushima T,Gao T,Tawara T,Hojo N,Isobe A,Yamane Y

更新日期：1997-01-01 00:00:00

abstract：:Amygdalin (D-mandelonitrile-beta-D-gentiobioside) is a cyanogenic glycoside claimed to show anti-cancer activity, sold under the incorrect name "Laetrile". For a sensible discussion of its alleged activity and its established toxicity it is necessary that its fate in the organism is known. The pharmacokinetics of amyg...

journal_title：Archives of toxicology

authors： Rauws AG,Olling M,Timmerman A

更新日期：1982-03-01 00:00:00

abstract：:The possibility that the exposure of the embryo to certain chemical substances can lead to behavioral disturbances is known from human epidemiological studies, e.g., in chronic poisoning with mercury and ethanol. Therefore, efforts are made to develop toxicological techniques with which new behavioral teratogens can b...

journal_title：Archives of toxicology

authors： Zbinden G

更新日期：1981-09-01 00:00:00

abstract：:Diet is directly related with physiological alterations occurring at a cell and subcellular level. However, the role of diet manipulation on mitochondrial physiology is still largely unexplored. Aiming at correlating diet with alterations of mitochondrial membrane composition and bioenergetics, Wistar-Han male rats we...

journal_title：Archives of toxicology

authors： Monteiro JP,Pereira CV,Silva AM,Maciel E,Baldeiras I,Peixoto F,Domingues MR,Jurado AS,Oliveira PJ

更新日期：2013-12-01 00:00:00

abstract：:The mycotoxin ochratoxin A (OTA) and its metabolite ochratoxin alpha (OT-alpha) were investigated, to examine their potency to induce sister chromatid exchanges (SCE) in cultured porcine urinary bladder epithelial cells (PUBEC) (primary culture). Serum-free cultured PUBEC were incubated for 5 h with either OTA or OT-a...

journal_title：Archives of toxicology

authors： Föllmann W,Hillebrand IE,Creppy EE,Bolt HM

更新日期：1995-01-01 00:00:00

abstract：:Assay conditions in determining total cytochrome P-450 in four laboratories were compared. Although the determination was derived from the original Omura and Sato method in each laboratory, the four standard protocols differed slightly, resulting in considerable differences in the results. Since the cytochrome P-450 c...

journal_title：Archives of toxicology

authors： Rutten AA,Falke HE,Catsburg JF,Topp R,Blaauboer BJ,van Holsteijn I,Doorn L,van Leeuwen FX

更新日期：1987-01-01 00:00:00

abstract：:Since teratogenicity testing in mammals is a particular challenge from an animal welfare perspective, there is a great need for the development of alternative test systems. In this context, the zebrafish (Danio rerio) embryo has received increasing attention as a non-protected embryonic vertebrate in vivo model. The p...

journal_title：Archives of toxicology

authors： Brotzmann K,Wolterbeek A,Kroese D,Braunbeck T

更新日期：2020-10-27 00:00:00

abstract：:The effect of various hepatotoxicants on urinary taurine and urinary creatine has been studied in the rat. Several hepatotoxic agents, carbon tetrachloride, thioacetamide, galactosamine and allyl alcohol which all caused hepatic necrosis (sometimes accompanied by steatosis), resulted in a rise in urinary taurine and i...

journal_title：Archives of toxicology

authors： Waterfield CJ,Turton JA,Scales MD,Timbrell JA

更新日期：1993-01-01 00:00:00

abstract：:Early hepatocyte death occurs in most liver injury cases and triggers liver inflammation, which in combination with other risk factors leads to the development of liver disease. However, the pathogenesis of early phase hepatocyte death remains poorly understood. Here, C57BL/6J mice were treated with the hepatotoxic dr...

journal_title：Archives of toxicology

authors： Song B,Aoki S,Liu C,Ito K

更新日期：2019-06-01 00:00:00

abstract：:Chronic exposure to propiverine, a frequently prescribed pharmaceutical for treatment of overactive bladder and incontinence, provokes massive protein accumulation in the cytosol and nucleus of renal proximal tubule epithelial cells in rats. Previously, the accumulating protein was identified as D-amino acid oxidase (...

journal_title：Archives of toxicology

authors： Luks L,Sacchi S,Pollegioni L,Dietrich DR

更新日期：2017-01-01 00:00:00

abstract：:The effect of 1-deamino-2-tyr(ethyl) oxytocin (dEtOT) upon peri- and postnatal development of the rat was studied in two experiments when administered between day 15 of pregnancy and the day of parturition. The investigation showed that dEtOT did not affect the pups at birth, that dEtOT caused a dose-related growth re...

journal_title：Archives of toxicology

authors： Magnusson G,Melin P

更新日期：1985-09-01 00:00:00

abstract：:Rats were coexposed to lead (Pb) and Copper (Cu) through drinking water and intraperitoneally, respectively, for a period of 21 days. Neurochemical studies in these rats showed significant reduction in the activity of adenosine triphosphatase, cytochrome-c-oxidase, diaphorase and in the levels of biogenic amines in th...

journal_title：Archives of toxicology

authors： Malhotra KM,Shukla GS,Chandra SV

更新日期：1982-03-01 00:00:00

abstract：:Organotin compounds such as tributyltin (TBT) and triphenyltin can induce diabetes and insulin resistance. However, the development of diabetes caused by organotins and its underlying mechanisms remain unclear. In the present study, male KM mice were orally administered with TBT (0.5, 5, and 50 μg/kg) once every 3 day...

journal_title：Archives of toxicology

authors： Li B,Guo J,Xi Z,Xu J,Zuo Z,Wang C

更新日期：2017-10-01 00:00:00

abstract：:The objective of this study was to evaluate the role of apoptosis in the development of the newborn cochlear structures and hearing loss caused by prenatal cis-diaminedichloroplatinum (cisplatin) exposure. Pregnant albino guinea pigs were intraperitoneally injected with 1.5 mg/kg body weight cisplatin once a day for s...

journal_title：Archives of toxicology

authors： Hao S,Jiang X,Yan A,Yang B

更新日期：2011-01-01 00:00:00

abstract：:Evading apoptosis and chemo-resistance are considered as very important factors which help tumour progression and metastasis. Hence, to overcome chemo-resistance, there is an urgent requirement for emergence of more effective treatment options. Myricetin, a naturally occurring flavonoid, is present in various plant-de...

journal_title：Archives of toxicology

authors： Akhtar S,Najafzadeh M,Isreb M,Newton L,Gopalan RC,Anderson D

更新日期：2021-01-01 00:00:00

abstract：:Using isolated rat hepatocytes the biochemical effects of hydrazine have been investigated using both conventional assay techniques and high resolution proton NMR. High resolution proton NMR revealed that hydrazine caused a significant increase in alanine and lactate levels in the incubation buffer, whereas levels of ...

journal_title：Archives of toxicology

authors： Ghatineh S,Morgan W,Preece NE,Timbrell JA

更新日期：1992-01-01 00:00:00

abstract：:A wide variety of immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in experimental animals has been documented. In contrast, the impact of dioxin on the human immune system remains controversial, although adverse health effects have been reported in humans after occupational or accidental exposu...

journal_title：Archives of toxicology

authors： Lang DS,Becker S,Clark GC,Devlin RB,Koren HS

更新日期：1994-01-01 00:00:00