Abstract:
:Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and death, resulting in acute kidney injury (AKI). Recent studies have suggested that DNA damage and the associated DNA damage response (DDR) are an important pathogenic mechanism of AKI following cisplatin treatment. Activation of DDR may lead to cell cycle arrest and DNA repair for cell survival or, in the presence of severe injury, kidney cell death. Modulation of DDR may provide novel renoprotective strategies for cancer patients undergoing cisplatin chemotherapy.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Zhu S,Pabla N,Tang C,He L,Dong Zdoi
10.1007/s00204-015-1633-3subject
Has Abstractpub_date
2015-12-01 00:00:00pages
2197-205issue
12eissn
0340-5761issn
1432-0738pii
10.1007/s00204-015-1633-3journal_volume
89pub_type
杂志文章,评审abstract::Dinitrochlorobenzene (DNCB) absorption through mouse and rat dorsal skin, pig ear skin and human abdominal skin in vitro was determined, and local metabolism to the glutathione conjugate was related to glutathione transferase activities and glutathione status in the skin. Absorption studies were conducted using skin m...
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