Abstract：
:Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and death, resulting in acute kidney injury (AKI). Recent studies have suggested that DNA damage and the associated DNA damage response (DDR) are an important pathogenic mechanism of AKI following cisplatin treatment. Activation of DDR may lead to cell cycle arrest and DNA repair for cell survival or, in the presence of severe injury, kidney cell death. Modulation of DDR may provide novel renoprotective strategies for cancer patients undergoing cisplatin chemotherapy.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Zhu S,Pabla N,Tang C,He L,Dong Zdoi
10.1007/s00204-015-1633-3subject
Has Abstractpub_date
2015-12-01 00:00:00pages
2197-205issue
12eissn
0340-5761issn
1432-0738pii
10.1007/s00204-015-1633-3journal_volume
89pub_type
杂志文章,评审abstract：:Dinitrochlorobenzene (DNCB) absorption through mouse and rat dorsal skin, pig ear skin and human abdominal skin in vitro was determined, and local metabolism to the glutathione conjugate was related to glutathione transferase activities and glutathione status in the skin. Absorption studies were conducted using skin m...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000123
更新日期：2000-09-01 00:00:00
abstract：:Carbromal is metabolized extensively in humans. The major metabolites known to date are bromoethylbutyramide, ethylbutyrylurea and inorganic bromide. After ingestion of a therapeutic dose of 1.0 g carbromal (4.2 mmoles) by four healthy volunteers highest concentrations in serum were found to be for carbromal 30 mumole...
journal_title：Archives of toxicology
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doi：10.1007/BF00364653
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abstract：:Rhabdomyolysis has been reported in patients who abuse synthetic cannabinoids. However, no studies have yet assessed whether these cases reflect the direct cytotoxicity of synthetic cannabinoids on skeletal muscle, a possibility that the present study sought to address. Specifically, this study investigated the cytoto...
journal_title：Archives of toxicology
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journal_title：Archives of toxicology
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pub_type： 杂志文章
doi：10.1007/s00204-015-1554-1
更新日期：2016-06-01 00:00:00
abstract：:Volunteers inhaled a constant concentration of 50 ppm trichloroethylene (Tri) for 6 hrs per day on 5 consecutive days. Simultaneous ethanol (EtOH) ingestion (blood level 0.6%) inhibits the metabolization of Tri to trichloroethanol (TCE) and trichloroacetic acid (TCA) by 40% on the average. Oxidation of Tri to TCA does...
journal_title：Archives of toxicology
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journal_title：Archives of toxicology
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journal_title：Archives of toxicology
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更新日期：1995-01-01 00:00:00
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更新日期：2012-12-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-002-0418-7
更新日期：2003-02-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-018-2179-y
更新日期：2018-05-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-007-0230-5
更新日期：2008-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00332352
更新日期：1981-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0102-4
更新日期：2006-12-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050499
更新日期：1998-04-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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journal_title：Archives of toxicology
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更新日期：1987-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02415-8
更新日期：2019-04-01 00:00:00
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journal_title：Archives of toxicology
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更新日期：2015-11-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF01972990
更新日期：1990-01-01 00:00:00
abstract：:Since teratogenicity testing in mammals is a particular challenge from an animal welfare perspective, there is a great need for the development of alternative test systems. In this context, the zebrafish (Danio rerio) embryo has received increasing attention as a non-protected embryonic vertebrate in vivo model. The p...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02928-7
更新日期：2020-10-27 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章,评审
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-010-0518-8
更新日期：2010-06-01 00:00:00
abstract：:In female rats, the lethality and hepatotoxicity of cerous chloride (CeCl3) were significantly altered by pretreatment with steroidal and nonsteroidal compounds (pregnenolone-16alpha-carbonitrile "PCN", dexamethasone, spironolactone, phenobarbital) that stimulate hepatic drug-metabolizine enzyme activity and by estrad...
journal_title：Archives of toxicology
pub_type： 杂志文章
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更新日期：1976-03-11 00:00:00
abstract：:Knowledge about established breast carcinogens can support improved and modernized toxicological testing methods by identifying key mechanistic events. Ionizing radiation (IR) increases the risk of breast cancer, especially for women and for exposure at younger ages, and evidence overall supports a linear dose-respons...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-020-02752-z
更新日期：2020-05-01 00:00:00
