Abstract：
:The metabolism of 74As-arsenate (As V, 0.4 mg As/kg body weight, IV) in marmoset monkeys (two males and two females) was studied. Unlike all other animal species studied so far, the marmoset was found to be unable to metabolize the arsenate to dimethylarsinic acid. Most of the absorbed arsenate was reduced to arsenite (As III) in vivo. Only 20% was excreted in the urine as unchanged As V. A further 20% of the dose was excreted as As III. The rest of the As III produced was bound to the tissues, giving a distribution picture very similar to that reported earlier for marmoset monkeys given arsenite. The tissues with longest retention of arsenic were the liver, upper gastrointestinal tract (oral cavity and esophagus), skin, kidneys and gall bladder. The pronounced accumulation in the liver resulted from specific binding of arsenic to the rough microsomal membranes, unique to this animal species.
journal_name
Arch Toxicoljournal_title
Archives of toxicologyauthors
Vahter M,Marafante Edoi
10.1007/BF00343121subject
Has Abstractpub_date
1985-06-01 00:00:00pages
119-24issue
2eissn
0340-5761issn
1432-0738journal_volume
57pub_type
杂志文章abstract：:Pyrrolizidine alkaloids (PAs) are widely occurring phytotoxins which can induce severe liver damage in humans and other mammalian species by mechanisms that are not fully understood. Therefore, we investigated the development of PA hepatotoxicity in vivo, using an acutely toxic dose of the PA senecionine in mice, in c...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02582-8
更新日期：2020-01-01 00:00:00
abstract：:The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized phenethylamine-type NPS that acts as a 5-hydroxyindoleacetic acid (5-HT) receptor agonist, but little is known about its pharmacological effects...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02740-3
更新日期：2020-07-01 00:00:00
abstract：:Sertoli cells play a critical role in spermatogenesis, and in adults, they are terminally differentiated with loss of proliferative activity. This study revealed Sertoli cell proliferation in 17-week-old Sprague-Dawley rats whose dams had been intragastrically administered 250 ng of 3,3',4,4',5-pentachlorobiphenyl/kg ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-011-0736-8
更新日期：2012-01-01 00:00:00
abstract：: ...
journal_title：Archives of toxicology
pub_type： 评论,信件
doi：10.1007/s00204-018-2384-8
更新日期：2019-01-01 00:00:00
abstract：:Hydroxysteroid sulfotransferase 2B1b (SULT2B1b) sulfates cholesterol and oxysterols. Hepatic oval cells (HOCs), thought to be progenitor cells, can be triggered in chemically injured livers. The present study focused on the role of SULT2B1b in HOC proliferation after liver injury. Our experiments revealed that the exp...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-016-1693-z
更新日期：2017-01-01 00:00:00
abstract：:Standard treatment of poisoning by organophosphates (OP) includes the administration of an antimuscarinic agent, e.g. atropine, and of an acetylcholinesterase (AChE) reactivator (oxime). The presently available oximes, obidoxime and pralidoxime (2-PAM), are considered to be insufficient for highly toxic OPs, e.g. sari...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-002-0375-1
更新日期：2002-09-01 00:00:00
abstract：:Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, di...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00296955
更新日期：1987-01-01 00:00:00
abstract：:Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and de...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/s00204-015-1633-3
更新日期：2015-12-01 00:00:00
abstract：UNLABELLED:An overdose of acetaminophen (APAP) causes hepatotoxicity due to its metabolite, N-acetyl-p-benzoquinone imine. NAD(P)H:quinone oxidoreductase 1 (NQO1) is an important enzyme for detoxification, because it catabolizes endogenous/exogenous quinone to hydroquinone. Although various studies have suggested the ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-014-1340-5
更新日期：2015-11-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00294994
更新日期：1983-08-01 00:00:00
abstract：:Cyclic AMP (c-AMP), added on its own to rat hepatocyte cultures, caused a marked accumulation of coproporphyrin III. The results obtained by comparing the effect of c-AMP to that of exogenous 5-aminolevulinate (ALA), and from adding c-AMP and ALA together, indicated that the coproporphyrinogen III metabolism was block...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-004-0637-1
更新日期：2005-07-01 00:00:00
abstract：:Cocaine is an intrinsic hepatotoxin in laboratory animals, and there is growing evidence that high doses of cocaine can precipitate hepatic necrosis in humans. The rodent model of cocaine hepatotoxicity is commensurate with the concept that a multistep mainly cytochrome P-450 dependent N-oxidative pathway is responsib...
journal_title：Archives of toxicology
pub_type： 杂志文章,评审
doi：10.1007/BF02284256
更新日期：1991-01-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000141
更新日期：2000-10-01 00:00:00
abstract：:Previous rat toxicity studies of alpha-glycosyl isoquercitrin (AGIQ), a water-soluble flavonol glycoside derived from rutin, revealed systemic yellow bone discoloration. This investigative study was conducted to determine the AGIQ metabolite(s) responsible for the discoloration. Female Sprague-Dawley rats were adminis...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02760-z
更新日期：2020-07-01 00:00:00
abstract：:Sunitinib (SNT) is a multi-targeted receptor tyrosine kinase inhibitor that has been approved by the FDA for cancer therapy. However, its cardiotoxicity has limited the clinical applicability with no effective therapeutic approach available. As a broadband kinase inhibitor, the function of several kinases that are ess...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-019-02448-z
更新日期：2019-06-01 00:00:00
abstract：:Carbromal is metabolized extensively in humans. The major metabolites known to date are bromoethylbutyramide, ethylbutyrylurea and inorganic bromide. After ingestion of a therapeutic dose of 1.0 g carbromal (4.2 mmoles) by four healthy volunteers highest concentrations in serum were found to be for carbromal 30 mumole...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00364653
更新日期：1978-06-16 00:00:00
abstract：:Okadaic acid (OA) is produced by several types of dinoflagellates (marine plankton) and has been implicated as the causative agent of diarrhetic shellfish syndrome. Previous studies have shown that okadaic acid is a tumor promoter and a specific potent inhibitor of protein phosphatases and protein synthesis. These eff...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0460-0
更新日期：2003-11-01 00:00:00
abstract：:The oxidizing capacity of phagocytic cells is suspected to play a major role in the generation of immunogenic drug metabolites, in particular those that cause extrahepatic immunopathological lesions. In the case of the antirheumatic drug gold(I) disodium thiomalate (Na2Au(I)TM), oxidation of the Au(I) ion to Au(III) a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050198
更新日期：1995-01-01 00:00:00
abstract：:Rhabdomyolysis has been reported in patients who abuse synthetic cannabinoids. However, no studies have yet assessed whether these cases reflect the direct cytotoxicity of synthetic cannabinoids on skeletal muscle, a possibility that the present study sought to address. Specifically, this study investigated the cytoto...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-020-02944-7
更新日期：2020-11-10 00:00:00
abstract：:The release and availability of the carcinogenic component of the soluble azo dye Direct Red 46 and the insoluble azo pigment Pigment Yellow 17 were analyzed in Wistar rats using hemoglobin adducts as a dosimeter. The levels of hemoglobin adducts were found to be very low. Intestinal cleavage and release of 3,3'-dichl...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050024
更新日期：1994-01-01 00:00:00
abstract：:The flavonol quercetin shows a wide range of effects in biological systems. We investigated whether quercetin exerts its proposed antioxidant properties via the antioxidant enzyme system. Quercetin in a concentration range from 5 to 100 microM decreased manganese superoxide dismutase, glutathione peroxidase, and coppe...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-003-0482-7
更新日期：2003-09-01 00:00:00
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journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00352071
更新日期：1981-11-01 00:00:00
abstract：:Aliphatic nitriles are a class of chemicals used in high volumes in the production of plastics and elastomers, in organic synthesis, and in production of a number of food packaging containers. Toxicity and metabolism of acrylonitrile (AN) are well characterized. On the other hand, minimal information is available on t...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF03208340
更新日期：1994-01-01 00:00:00
abstract：:The aim of this study was to investigate the genotoxic potential of DNA adducts and to compare DNA adduct levels and patterns in petroleum vacuum distillates, coal tar distillate, bitumen fume condensates, and related substances that have a wide range of boiling temperatures. An in vitro assay was used for DNA adduct ...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040000172
更新日期：2001-01-01 00:00:00
abstract：:The effects of six iv infusions of an emulsion containing the plasticizer di(2-ethylhexyl) phthalate (DEHP) on the liver and testes were investigated in 40-day-old rats. Groups of five to six animals received the emulsion every other day in doses of 0, 5, 50 or 500 mg DEHP/kg body weight. Liver effects were studied by...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/BF00348313
更新日期：1985-12-01 00:00:00
abstract：:Darbepoetin (DPO), an erythropoietin (EPO) derivative, was licensed in 2002 to treat patients with solid tumors suffering from chemotherapy-dependent anemia, although various tumors express EPO to improve vascularization, thus favoring tumor growth and spreading. Therefore, we wanted to investigate direct effects of D...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-013-1094-5
更新日期：2014-01-01 00:00:00
abstract：:Phytoestrogens have been described as weak estrogens, selective estrogen receptor mediators (SERMs) or to exhibit antiestrogenic properties. However, information about their activity in combination with xenoestrogens and 17beta-estradiol in vivo, is limited. Therefore, the combinatory activity of the phytoestrogen gen...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-006-0102-4
更新日期：2006-12-01 00:00:00
abstract：:In order to clarify the possible mechanism of hepatocarcinogenesis induced by piperonyl butoxide, we attempted to identify the transcription factor activated by piperonyl butoxide in the male ICR mouse liver. Administration of 0.6% piperonyl butoxide for 24 h elevated the level of liver nuclear proteins that bind to a...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s00204-008-0283-0
更新日期：2008-10-01 00:00:00
abstract：:This study examined the effect of tamoxifen, an anti-breast cancer drug, on Ca2+ handling in bladder female transitional cancer cells. Changes in cytosolic free Ca2+ levels were recorded by using the Ca2+-sensitive dye fura-2. In a dose-dependent manner, tamoxifen induced intracellular free Ca2+ concentrations ([Ca2+]...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040100212
更新日期：2001-05-01 00:00:00
abstract：:Quantitative structure-activity relationships (QSAR) have suggested the importance of hydrogen bonding in relation to activation of the sensory irritant receptor by nonreactive volatile organic chemicals. To investigate this possibility further, three model compounds with different hydrogen bond acidity, trifluoroetha...
journal_title：Archives of toxicology
pub_type： 杂志文章
doi：10.1007/s002040050281
更新日期：1996-01-01 00:00:00
