听力与言语-语言病理学

行为科学

医学伦理学

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  • Potential Drug Interactions between Recombinant Interleukin-2 and Direct Oral Anticoagulants: Indirect Evidence from In Vivo Animal Studies.

    abstract::Recombinant interleukin-2 (rIL-2) is indicated for metastatic renal cell carcinoma and melanoma. Over recent years low-dose rIL-2 has been studied for the treatment of autoimmune diseases and acute coronary syndrome because of its ability to expand and activate T regulatory (Treg) cells. However, several medical condi...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.1055/a-1120-4064

    authors: Mahmoudpour SH,Valerio L,Douxfils J,Mahan CE,Jankowski M,Quitzau K,Konstantinides SV,Barco S

    更新日期:2020-12-01 00:00:00

  • In Vitro Closure Times (PFA-100) Are Different Between Peritoneal Dialysis and Hemodialysis.

    abstract:INTRODUCTION: Platelet dysfunction is not uncommon in patients with end-stage renal disease (ESRD). Type of renal replacement therapy may have an effect on platelet functions, which has not been well investigated. We evaluated in vitro closure time (CT) differences between peritoneal dialysis (PD) and hemodialysis (HD)...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.1055/a-1171-0499

    authors: Gokalp C,Karadag FK,Braunisch MC,Schmaderer C,Gunay E,Kiper HD,Tobu M,Ustün C,Demirci MS,Ozkahya M

    更新日期:2020-12-01 00:00:00

  • Analysis of an Inherited Dysfibrinogenemia Pedigree Associated with a Heterozygous Mutation in the FGA Gene.

    abstract:OBJECTIVE: This article aims to analyze the phenotype and genotype of an inherited dysfibrinogenemia pedigree associated with a heterozygous mutation in the FGA gene, and to investigate the pathogenesis of this disease. CLINICAL PRESENTATION: The proband of interest is a 29-year-old woman. She was in her 37 weeks of g...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.1055/a-1261-3884

    authors: Li S,Wang M,Li X,Xu Q,Liu S,Luo S,Chen Y

    更新日期:2020-12-01 00:00:00

  • Clinical Problem Solving and Using New Paths in the Laboratory: Learning from Case Studies.

    abstract::Three selected casuistic studies of individual patient problems from my long-standing professional experience are presented. I intend to highlight the potential contribution of case studies, including new approaches of laboratory investigation, for the advancement of pathophysiological knowledge and would encourage to...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.1055/a-1191-7198

    authors: Lämmle B

    更新日期:2020-11-01 00:00:00

  • Understanding and Preventing Placenta-Mediated Pregnancy Complications.

    abstract::Placenta-mediated pregnancy complications are clinically important conditions and include preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss. Pathophysiology is complex, and may be linked to prothrombotic disorders such as antiphospholipid syndrome, whose understanding is still evo...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.1055/a-1184-8388

    authors: Skeith L,Blondon M,Ní Áinle F

    更新日期:2020-08-01 00:00:00

  • How Do I Reverse Oral and Parenteral Anticoagulants?

    abstract::An understanding of reversal strategies alone is important to safely and effectively care for patients in cases of bleeding or invasive procedures. The recent diversification in the number of licensed anticoagulants makes an understanding of drug-specific reversal strategies essential. Intravenous or oral vitamin K ca...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/a-1113-0557

    authors: Koscielny J,Rutkauskaite E,Sucker C,von Heymann C

    更新日期:2020-06-01 00:00:00

  • Health Care Transition of Adolescents and Young Adults with Haemophilia: the Situation in Germany and the Munich experience.

    abstract::Patients suffering from haemophilia encounter various phases in life, in which individual needs, life situations, and self- and disease perception change rapidly. One of these phases spans from the beginning of puberty until early adulthood, in which individuals gain self-responsibility and reach independence and auto...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-3402804

    authors: Bidlingmaier C,Olivieri M,Schilling FH,Kurnik K,Pekrul I

    更新日期:2020-02-01 00:00:00

  • How I Manage Thrombotic/Thromboembolic Complications in Myeloproliferative Neoplasms.

    abstract::Patients with myeloproliferative neoplasms (MPNs), such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are at increased risk for arterial and venous thrombosis/thromboembolism. In particular, the risk of splanchnic venous thrombosis, such as portal vein thrombosis or Budd-Chiari syndrome, ...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0040-1701474

    authors: Koschmieder S

    更新日期:2020-02-01 00:00:00

  • IWR-1 Inhibits Collagen-Induced Platelet Activation and Protects against Thrombogenesis.

    abstract::Platelets play a crucial role in haemostasis and several pathophysiological processes. Collagen is a main initiator for platelet activation and aggregation. Given that Wnt signalling negatively regulates platelet function, and IWR-1 (a small molecule inhibitor for Wnt signalling) has the potential of inhibiting collag...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.1055/s-0038-1676822

    authors: Wang W,Lai S,Xiao Z,Yan H,Li Y,Zhang Y,Wu Y,Wang L

    更新日期:2019-11-01 00:00:00

  • Apixaban for the Treatment of Chronic Disseminated Intravascular Coagulation: A Report of Two Cases.

    abstract::Characteristic features of disseminated intravascular coagulation (DIC) are the opposing risks of bleeding (due to consumptive coagulopathy and hyperfibrinolysis) and organ failure (due to widespread microvascular thromboses). The purpose of anticoagulation in DIC is to attenuate excessive thrombin generation and fibr...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.1055/s-0038-1675386

    authors: Janjetovic S,Holstein K,Dicke C,Bokemeyer C,Langer F

    更新日期:2019-08-01 00:00:00

  • Cofactor-Independent Antiphospholipid Antibodies: Implications for Pathogenesis, Diagnosis, and Treatment of Antiphospholipid Syndrome.

    abstract::The antiphospholipid syndrome (APS) has occupied haemostaseologists, rheumatologists and obstetricians since its initial description 35 years ago. Its name has been coined because of the antibodies against phospholipids which were the common property of affected patients. In particular, the pathogenesis of APS has bee...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0038-1675355

    authors: Lackner KJ,Müller-Calleja N

    更新日期:2019-06-01 00:00:00

  • Potential of Multidimensional, Large-scale Biodatabases to Elucidate Coagulation and Platelet Pathways as an Approach towards Precision Medicine in Thrombotic Disease.

    abstract::Cardiovascular and especially thrombotic diseases remain a major cause of morbidity and mortality worldwide. In past years, significant improvements in understanding disease processes, risk assessment, and prediction of clinical outcome in the field of thrombosis and haemostasis have been made by using large-scale bio...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0038-1677520

    authors: Panova-Noeva M,Eggebrecht L,Prochaska JH,Wild PS

    更新日期:2019-06-01 00:00:00

  • Coagulation Signalling and Metabolic Disorders: Lessons Learned from Animal Models.

    abstract::Nutrient excess in obesity drives metabolic reprogramming in multiple tissues involving extensive interorgan and intercellular crosstalk. Experimental and clinical studies show that prolonged nutrient excess often compromises metabolic adaptation propagating proobesogenic and proinflammatory responses. Chronic inflamm...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1688800

    authors: Madhusudhan T,Ruf W

    更新日期:2019-06-01 00:00:00

  • Acquired Haemophilia A Associated with Subsequent Hepatocellular Carcinoma.

    abstract::Acquired haemophilia A (AHA) is a rare autoimmune disease caused by antibodies directed against clotting factor VIII. About half of cases are idiopathic, but AHA may also be secondary to autoimmune, dermatologic, or oncologic diseases. In approximately 10% of non-idiopathic cases, the disease occurs after or with the ...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.1055/s-0038-1668570

    authors: Pacholczak R,Bazan-Socha S,Zdziarska J,Iwaniec T,Walocha JA,Musiał J,Dropiński J

    更新日期:2019-02-01 00:00:00

  • The Role of Low Molecular Weight Heparins for Venous Thromboembolism Prevention in Medical Patients-What Is New in 2019?

    abstract::Low molecular weight heparins and fondaparinux have been the cornerstones for prevention of venous thromboembolism (VTE) in acutely ill medical patients for almost two decades. Guidelines recommend the use of these parenteral anticoagulants for 6 to 14 days but advise against extended-duration thromboprophylaxis after...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0038-1677522

    authors: Haas S

    更新日期:2019-02-01 00:00:00

  • Birth Control Pills and Thrombotic Risks: Differences of Contraception Methods with and without Estrogen.

    abstract::In Germany one-third of the women in fertile age use combined oral contraceptives (COCs), which consist mostly of ethinylestradiol (EE) and a synthetic progestin. Older COCs with norethisterone or levonorgestrel have a lower risk for venous thromboembolism (VTE) than newer COCs with desogestrel, drospirenone, or gesto...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1677806

    authors: Rott H

    更新日期:2019-02-01 00:00:00

  • Child Abuse or Bleeding Disorder-An Interdisciplinary Approach.

    abstract::Children with an unexplained bleeding tendency are frequently referred to a haemostaseologist for further evaluation. Careful standardized history taking and clinical evaluation should allow for distinguishing bleeds after minor injury and trauma which are very common in all children. However, in two groups of childre...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1677714

    authors: Knöfler R,Streif W,Watzer-Herberth I,Hahn G,Schmidt U

    更新日期:2019-02-01 00:00:00

  • Trauma-Induced Coagulopathy.

    abstract::Trauma-induced coagulopathy (TIC) is a heterogeneous entity that contributes to a significant morbidity and mortality following trauma. The activated protein C system, endotheliopathy and platelet dysfunction have been implicated in the pathogenesis of TIC, although there are still controversies on the exact pathogene...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1677853

    authors: Petros S

    更新日期:2019-02-01 00:00:00

  • Platelet Signaling in Primary Haemostasis and Arterial Thrombus Formation: Part 1.

    abstract::Platelets react immediately in response to traumatic vascular injury by adhesion, activation, aggregation and subsequent haemostatic plug formation. While this reaction pattern is essential for haemostasis, platelet responses can also cause occlusive thrombi in diseased arteries, leading to myocardial infarction or st...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.1055/s-0038-1675144

    authors: Scharf RE

    更新日期:2018-11-01 00:00:00

  • Feasibility and Results of a Mobile Haemophilia Outpatient Care Pilot Project.

    abstract:INTRODUCTION: Regular visits at haemophilia treatment centres (HTCs) in rural regions are often dependent on the access to a private car due to lack of or limited availability of public means. Therefore, a mobile haemophilia outpatient care (MHOC) concept providing home visits to haemophilia patients has been developed...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.1055/s-0038-1654721

    authors: Eichler H,Schleicher C,Heine S,Graf N,von Mackensen S

    更新日期:2018-08-01 00:00:00

  • The Impact of Bleeding Disorders on the Socioeconomic Status of Adult Patients.

    abstract::The impact of inherited bleeding disorders on the socioeconomic status (SES) of affected individuals is not clear. The SES of adult patients with congenital bleeding disorders (PWBD) from a centre in Germany (age 42.3 ± 15.0 years) was compared to that of a gender- and age-matched control group of patients with thromb...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.5482/HAMO-16-12-0047

    authors: Holstein K,von Mackensen S,Bokemeyer C,Langer F

    更新日期:2018-08-01 00:00:00

  • Subchondral haematoma.

    abstract::Haemophilic arthropathy is a complex multifactorial disorder that poses significant challenges to both the treating haematologist and arthroplasty surgeon. Its pathogenesis is incompletely understood. Recent literature has concentrated on the toxic effects of iron and the characteristic inflammatory synovitis. Discuss...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.5482/HAMO-15-12-0033

    authors: Wharton R,Austin S,Back D

    更新日期:2017-01-01 00:00:00

  • Follow-up of a 6-month Programmed Sports Therapy (PST) in patients with haemophilia.

    abstract::Studies describe benefits of exercise in Patients with haemophilia (PwH), but research on training sustainability is rare. Aim of this study was to observe the follow-up of a guided 6-month training intervention in PwH. This study included 28 PwH after a training intervention (RCT) over 6 months. N=17 continued traini...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,随机对照试验

    doi:10.5482/HAMO-17-04-0016

    authors: Runkel B,Hilberg T

    更新日期:2017-01-01 00:00:00

  • DOAC use in patients with chronic kidney disease.

    abstract::Direct oral anticoagulants (DOACs) are increasingly prescribed substances in patients with indication for effective anticoagulation. Patients with chronic kidney disease (CKD) have a high burden of cardiovascular risk and are more likely to develop atrial fibrillation (AF) than patients without CKD. Patients with mild...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-17-01-0003

    authors: Kcükköylü S,Rump LC

    更新日期:2017-01-01 00:00:00

  • VKCFD2 - from clinical phenotype to molecular mechanism.

    abstract::Vitamin K 2,3-epoxide reductase complex, subunit 1 (VKORC1) is an enzyme essential for the vitamin K cycle. VKORC1 catalyses the reduction of vitamin K 2,3-epoxide to the quinone form of vitamin K and further to vitamin K hydroquinone. The generated vitamin K hydroquinone serves as substrate for the enzyme γ-glutamyl-...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:

    authors: Czogalla KJ,Watzka M,Oldenburg J

    更新日期:2016-11-08 00:00:00

  • Do we need antiplatelet therapy in thrombocytosis? Pro. Diagnostic and pathophysiologic considerations for a treatment choice.

    abstract::Thrombocytosis (defined as platelets >450 x 109/l) has several aetiologies. After having excluded spurious thrombocytosis (e. g., due to microspherocytes, schistocytes, cryoglobulins, or bacteria), the differential diagnosis of true thrombocytosis encompasses secondary causes (as diverse as inflammation, infection, ma...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-14-11-0074

    authors: Alberio L

    更新日期:2016-11-07 00:00:00

  • RhoGAPs and Rho GTPases in platelets.

    abstract::Platelet cytoskeletal reorganization is essential for platelet adhesion and thrombus formation in hemostasis and thrombosis. The Rho GTPases RhoA, Rac1 and Cdc42 are the main players in cytoskeletal dynamics of platelets responsible for the formation of filopodia and lamellipodia to strongly increase the platelet surf...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-14-09-0046

    authors: Elvers M

    更新日期:2016-08-03 00:00:00

  • Oxidative stress, NADPH oxidases, and arteries.

    abstract::Atherosclerosis and its major complications - myocardial infarction and stroke - remain major causes of death and disability in the United States and world-wide. Indeed, with dramatic increases in obesity and diabetes mellitus, the prevalence and public health impact of cardiovascular diseases (CVD) will likely remain...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-14-11-0076

    authors: Sun QA,Runge MS,Madamanchi NR

    更新日期:2016-05-10 00:00:00

  • Oxidation-specific epitopes are major targets of innate immunity in atherothrombosis.

    abstract:UNLABELLED:Atherosclerosis is a chronic inflammatory disease of the vascular wall that results from disturbed lipoprotein metabolism and increased oxidative stress. A major consequence of this is lipid peroxidation, which generates a number of breakdown products of membrane lipids that form so called oxidation-specific...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-14-11-0069

    authors: Bartolini Gritti B,Binder CJ

    更新日期:2016-05-10 00:00:00

  • The vulnerable myocardium. Diabetic cardiomyopathy.

    abstract::Cardiovascular disease is the major cause of morbidity and mortality in subjects suffering from diabetes mellitus. While coronary artery disease is the leading cause of cardiac complications in diabetics, it is widely recognized that diabetes increases the risk for the development of heart failure independently of cor...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-14-09-0038

    authors: Bugger H,Bode C

    更新日期:2015-01-01 00:00:00

  • Management of acquired haemophilia A.

    abstract::Acquired haemophilia A (AHA) is caused by autoantibody inhibitors of coagulation factor VIII (FVIII : C). Recent onset of bleeds and isolated prolongation of the activated partial thromboplastin time (aPTT) are characteristic features of the disorder. Reduced FVIII : C activity and a detectable FVIII : C inhibitor in ...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-14-11-0064

    authors: Tiede A,Scharf RE,Dobbelstein C,Werwitzke S

    更新日期:2015-01-01 00:00:00

  • The role of the kynurenine pathway of tryptophan metabolism in cardiovascular disease. An emerging field.

    abstract::Coronary heart disease and stroke, the deadliest forms of cardiovascular disease (CVD), are mainly caused by atherosclerosis, a chronic inflammatory disease of the artery wall driven by maladaptive immune responses in the vessel wall. Various risk factors for CVD influence this pathogenic process, including diabetes m...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-14-10-0052

    authors: Polyzos KA,Ketelhuth DF

    更新日期:2015-01-01 00:00:00

  • Tissue factor pathways linking obesity and inflammation.

    abstract::Obesity is a major cause for a spectrum of metabolic syndrome-related diseases that include insulin resistance, type 2 diabetes, and steatosis of the liver. Inflammation elicited by macrophages and other immune cells contributes to the metabolic abnormalities in obesity. In addition, coagulation activation following t...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-14-11-0068

    authors: Ruf W,Samad F

    更新日期:2015-01-01 00:00:00

  • MRI, the technology for imaging of thrombi and inflammation.

    abstract::Atherosclerosis and its sequelae have a major impact on morbidity and mortality. The rupture of an inflamed atherosclerotic plaque is a crucial event, since it can result in acute thrombotic closure of an arterial vessel, resulting e. g. in myocardial infarction or stroke. Not only detection of early plaque rupture wi...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-14-11-0061

    authors: von Zur Muhlen C,Bode C

    更新日期:2015-01-01 00:00:00

  • [Bleedings under NOAC (non Vitamin-K dependent oral anticoagulants). Evidence and practical management].

    abstract:UNLABELLED:The doses of these drugs are barely tested and the potential clinical thromboembolic risk must be taken into account. Despite the widespread use of NOAC (non vitamin-K dependent oral anticoagulants) and recommendations of regulatory agencies and first consensus meeting on handling the bleeding situation unde...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:

    authors: Koscielny J,Rutkauskaite E

    更新日期:2015-01-01 00:00:00

  • The vulnerable blood.

    abstract::Patients with diabetes are at increased risk of cardiovascular morbidity and mortality. While arteriosclerotic lesions have long been recognized as the underlying cause more recent studies suggest that alterations of the blood are also critically involved. Following plaque rupture, adherence of platelets is followed b...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.5482/HAMO-14-09-0039

    authors: Hess K

    更新日期:2015-01-01 00:00:00

  • Anticoagulation during and after acute coronary syndrome.

    abstract::Current antithrombotic therapy in patients with acute coronary syndrome (ACS) comprises antiplatelet and anticoagulant therapy. Dual antiplatelet therapy composed of aspirin plus a third generation P2Y12 inhibitor (prasugrel or ticagrelor) represents the gold standard, while aspirin plus second generation P2Y12 inhibi...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-13-09-0048

    authors: Ahrens I,Bode C,Zirlik A

    更新日期:2014-01-01 00:00:00

  • Recurrent cerebral ischaemia in a pregnant woman with patent foramen ovale II° and thrombophilia.

    abstract::This case report concerns a pregnant multipara (age: 27 years) in the 16th gestational week. She developed a sudden onset of paraesthesia in her left lower arm although injecting dalteparin 5000 IU once daily subcutaneously (s. c.) due to a heterozygous factor V Leiden mutation and a prior miscarriage in the first pre...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.5482/HAMO-14-03-0022

    authors: Hecking C,Hendelmeier M,von Bardeleben R,Gröschel K,Schinzel H

    更新日期:2014-01-01 00:00:00

  • Hermansky-Pudlak syndrome. Overview of clinical and molecular features and case report of a new HPS-1 variant.

    abstract::Hermansky-Pudlak syndrome (HPS) is a rare, autosomal recessive disorder affecting lysosome-related organelles (LRO), including dense platelet granules. HPS causes oculocutaneous hypopigmentation, bleeding diathesis and granulomatous colitis or pulmonary fibrosis. To date, there is no curative treatment and the clinica...

    journal_title:Hamostaseologie

    pub_type: 杂志文章,评审

    doi:10.5482/HAMO-14-06-0024

    authors: Sánchez-Guiu I,Torregrosa JM,Velasco F,Antón AI,Lozano ML,Vicente V,Rivera J

    更新日期:2014-01-01 00:00:00

  • Clot waveform analysis in patients with haemophilia A.

    abstract:UNLABELLED:Clot waveform analysis extends the interpretation of aPTT measurement curves. The curve is mathematically processed to obtain information about fibrin formation kinetics including semiquantitative determination of thrombin, prothrombinase and tenase activity. PATIENTS, METHOD:In this study the feasibility o...

    journal_title:Hamostaseologie

    pub_type: 杂志文章

    doi:10.5482/HAMO-14-02-0016

    authors: Siegemund T,Scholz U,Schobess R,Siegemund A

    更新日期:2014-01-01 00:00:00

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