解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Recombinant interleukin-2 (rIL-2) is indicated for metastatic renal cell carcinoma and melanoma. Over recent years low-dose rIL-2 has been studied for the treatment of autoimmune diseases and acute coronary syndrome because of its ability to expand and activate T regulatory (Treg) cells. However, several medical condi...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1055/a-1120-4064
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE: This article aims to analyze the phenotype and genotype of an inherited dysfibrinogenemia pedigree associated with a heterozygous mutation in the FGA gene, and to investigate the pathogenesis of this disease. CLINICAL PRESENTATION: The proband of interest is a 29-year-old woman. She was in her 37 weeks of g...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1055/a-1261-3884
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION: Platelet dysfunction is not uncommon in patients with end-stage renal disease (ESRD). Type of renal replacement therapy may have an effect on platelet functions, which has not been well investigated. We evaluated in vitro closure time (CT) differences between peritoneal dialysis (PD) and hemodialysis (HD)...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1055/a-1171-0499
更新日期:2020-12-01 00:00:00
abstract::Three selected casuistic studies of individual patient problems from my long-standing professional experience are presented. I intend to highlight the potential contribution of case studies, including new approaches of laboratory investigation, for the advancement of pathophysiological knowledge and would encourage to...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1055/a-1191-7198
更新日期:2020-11-01 00:00:00
abstract::Placenta-mediated pregnancy complications are clinically important conditions and include preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss. Pathophysiology is complex, and may be linked to prothrombotic disorders such as antiphospholipid syndrome, whose understanding is still evo...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1055/a-1184-8388
更新日期:2020-08-01 00:00:00
abstract::An understanding of reversal strategies alone is important to safely and effectively care for patients in cases of bleeding or invasive procedures. The recent diversification in the number of licensed anticoagulants makes an understanding of drug-specific reversal strategies essential. Intravenous or oral vitamin K ca...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/a-1113-0557
更新日期:2020-06-01 00:00:00
abstract::Patients suffering from haemophilia encounter various phases in life, in which individual needs, life situations, and self- and disease perception change rapidly. One of these phases spans from the beginning of puberty until early adulthood, in which individuals gain self-responsibility and reach independence and auto...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0039-3402804
更新日期:2020-02-01 00:00:00
abstract::Patients with myeloproliferative neoplasms (MPNs), such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are at increased risk for arterial and venous thrombosis/thromboembolism. In particular, the risk of splanchnic venous thrombosis, such as portal vein thrombosis or Budd-Chiari syndrome, ...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0040-1701474
更新日期:2020-02-01 00:00:00
abstract::Platelets play a crucial role in haemostasis and several pathophysiological processes. Collagen is a main initiator for platelet activation and aggregation. Given that Wnt signalling negatively regulates platelet function, and IWR-1 (a small molecule inhibitor for Wnt signalling) has the potential of inhibiting collag...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1055/s-0038-1676822
更新日期:2019-11-01 00:00:00
abstract::Characteristic features of disseminated intravascular coagulation (DIC) are the opposing risks of bleeding (due to consumptive coagulopathy and hyperfibrinolysis) and organ failure (due to widespread microvascular thromboses). The purpose of anticoagulation in DIC is to attenuate excessive thrombin generation and fibr...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1055/s-0038-1675386
更新日期:2019-08-01 00:00:00
abstract::Nutrient excess in obesity drives metabolic reprogramming in multiple tissues involving extensive interorgan and intercellular crosstalk. Experimental and clinical studies show that prolonged nutrient excess often compromises metabolic adaptation propagating proobesogenic and proinflammatory responses. Chronic inflamm...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0039-1688800
更新日期:2019-06-01 00:00:00
abstract::The antiphospholipid syndrome (APS) has occupied haemostaseologists, rheumatologists and obstetricians since its initial description 35 years ago. Its name has been coined because of the antibodies against phospholipids which were the common property of affected patients. In particular, the pathogenesis of APS has bee...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0038-1675355
更新日期:2019-06-01 00:00:00
abstract::Cardiovascular and especially thrombotic diseases remain a major cause of morbidity and mortality worldwide. In past years, significant improvements in understanding disease processes, risk assessment, and prediction of clinical outcome in the field of thrombosis and haemostasis have been made by using large-scale bio...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0038-1677520
更新日期:2019-06-01 00:00:00
abstract::Trauma-induced coagulopathy (TIC) is a heterogeneous entity that contributes to a significant morbidity and mortality following trauma. The activated protein C system, endotheliopathy and platelet dysfunction have been implicated in the pathogenesis of TIC, although there are still controversies on the exact pathogene...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0039-1677853
更新日期:2019-02-01 00:00:00
abstract::Low molecular weight heparins and fondaparinux have been the cornerstones for prevention of venous thromboembolism (VTE) in acutely ill medical patients for almost two decades. Guidelines recommend the use of these parenteral anticoagulants for 6 to 14 days but advise against extended-duration thromboprophylaxis after...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0038-1677522
更新日期:2019-02-01 00:00:00
abstract::In Germany one-third of the women in fertile age use combined oral contraceptives (COCs), which consist mostly of ethinylestradiol (EE) and a synthetic progestin. Older COCs with norethisterone or levonorgestrel have a lower risk for venous thromboembolism (VTE) than newer COCs with desogestrel, drospirenone, or gesto...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0039-1677806
更新日期:2019-02-01 00:00:00
abstract::Acquired haemophilia A (AHA) is a rare autoimmune disease caused by antibodies directed against clotting factor VIII. About half of cases are idiopathic, but AHA may also be secondary to autoimmune, dermatologic, or oncologic diseases. In approximately 10% of non-idiopathic cases, the disease occurs after or with the ...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1055/s-0038-1668570
更新日期:2019-02-01 00:00:00
abstract::Children with an unexplained bleeding tendency are frequently referred to a haemostaseologist for further evaluation. Careful standardized history taking and clinical evaluation should allow for distinguishing bleeds after minor injury and trauma which are very common in all children. However, in two groups of childre...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0039-1677714
更新日期:2019-02-01 00:00:00
abstract::Platelets react immediately in response to traumatic vascular injury by adhesion, activation, aggregation and subsequent haemostatic plug formation. While this reaction pattern is essential for haemostasis, platelet responses can also cause occlusive thrombi in diseased arteries, leading to myocardial infarction or st...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.1055/s-0038-1675144
更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION: Regular visits at haemophilia treatment centres (HTCs) in rural regions are often dependent on the access to a private car due to lack of or limited availability of public means. Therefore, a mobile haemophilia outpatient care (MHOC) concept providing home visits to haemophilia patients has been developed...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.1055/s-0038-1654721
更新日期:2018-08-01 00:00:00
abstract::The impact of inherited bleeding disorders on the socioeconomic status (SES) of affected individuals is not clear. The SES of adult patients with congenital bleeding disorders (PWBD) from a centre in Germany (age 42.3 ± 15.0 years) was compared to that of a gender- and age-matched control group of patients with thromb...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.5482/HAMO-16-12-0047
更新日期:2018-08-01 00:00:00
abstract::Studies describe benefits of exercise in Patients with haemophilia (PwH), but research on training sustainability is rare. Aim of this study was to observe the follow-up of a guided 6-month training intervention in PwH. This study included 28 PwH after a training intervention (RCT) over 6 months. N=17 continued traini...
journal_title:Hamostaseologie
pub_type: 杂志文章,随机对照试验
doi:10.5482/HAMO-17-04-0016
更新日期:2017-01-01 00:00:00
abstract::Direct oral anticoagulants (DOACs) are increasingly prescribed substances in patients with indication for effective anticoagulation. Patients with chronic kidney disease (CKD) have a high burden of cardiovascular risk and are more likely to develop atrial fibrillation (AF) than patients without CKD. Patients with mild...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-17-01-0003
更新日期:2017-01-01 00:00:00
abstract::Haemophilic arthropathy is a complex multifactorial disorder that poses significant challenges to both the treating haematologist and arthroplasty surgeon. Its pathogenesis is incompletely understood. Recent literature has concentrated on the toxic effects of iron and the characteristic inflammatory synovitis. Discuss...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.5482/HAMO-15-12-0033
更新日期:2017-01-01 00:00:00
abstract::Vitamin K 2,3-epoxide reductase complex, subunit 1 (VKORC1) is an enzyme essential for the vitamin K cycle. VKORC1 catalyses the reduction of vitamin K 2,3-epoxide to the quinone form of vitamin K and further to vitamin K hydroquinone. The generated vitamin K hydroquinone serves as substrate for the enzyme γ-glutamyl-...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:
更新日期:2016-11-08 00:00:00
abstract::Thrombocytosis (defined as platelets >450 x 109/l) has several aetiologies. After having excluded spurious thrombocytosis (e. g., due to microspherocytes, schistocytes, cryoglobulins, or bacteria), the differential diagnosis of true thrombocytosis encompasses secondary causes (as diverse as inflammation, infection, ma...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-11-0074
更新日期:2016-11-07 00:00:00
abstract::Platelet cytoskeletal reorganization is essential for platelet adhesion and thrombus formation in hemostasis and thrombosis. The Rho GTPases RhoA, Rac1 and Cdc42 are the main players in cytoskeletal dynamics of platelets responsible for the formation of filopodia and lamellipodia to strongly increase the platelet surf...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-09-0046
更新日期:2016-08-03 00:00:00
abstract::Atherosclerosis and its major complications - myocardial infarction and stroke - remain major causes of death and disability in the United States and world-wide. Indeed, with dramatic increases in obesity and diabetes mellitus, the prevalence and public health impact of cardiovascular diseases (CVD) will likely remain...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-11-0076
更新日期:2016-05-10 00:00:00
abstract:UNLABELLED:Atherosclerosis is a chronic inflammatory disease of the vascular wall that results from disturbed lipoprotein metabolism and increased oxidative stress. A major consequence of this is lipid peroxidation, which generates a number of breakdown products of membrane lipids that form so called oxidation-specific...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-11-0069
更新日期:2016-05-10 00:00:00
abstract::Acquired haemophilia A (AHA) is caused by autoantibody inhibitors of coagulation factor VIII (FVIII : C). Recent onset of bleeds and isolated prolongation of the activated partial thromboplastin time (aPTT) are characteristic features of the disorder. Reduced FVIII : C activity and a detectable FVIII : C inhibitor in ...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-11-0064
更新日期:2015-01-01 00:00:00
abstract:UNLABELLED:The doses of these drugs are barely tested and the potential clinical thromboembolic risk must be taken into account. Despite the widespread use of NOAC (non vitamin-K dependent oral anticoagulants) and recommendations of regulatory agencies and first consensus meeting on handling the bleeding situation unde...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:
更新日期:2015-01-01 00:00:00
abstract::Patients with diabetes are at increased risk of cardiovascular morbidity and mortality. While arteriosclerotic lesions have long been recognized as the underlying cause more recent studies suggest that alterations of the blood are also critically involved. Following plaque rupture, adherence of platelets is followed b...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.5482/HAMO-14-09-0039
更新日期:2015-01-01 00:00:00
abstract::Coronary heart disease and stroke, the deadliest forms of cardiovascular disease (CVD), are mainly caused by atherosclerosis, a chronic inflammatory disease of the artery wall driven by maladaptive immune responses in the vessel wall. Various risk factors for CVD influence this pathogenic process, including diabetes m...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-10-0052
更新日期:2015-01-01 00:00:00
abstract::Atherosclerosis and its sequelae have a major impact on morbidity and mortality. The rupture of an inflamed atherosclerotic plaque is a crucial event, since it can result in acute thrombotic closure of an arterial vessel, resulting e. g. in myocardial infarction or stroke. Not only detection of early plaque rupture wi...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-11-0061
更新日期:2015-01-01 00:00:00
abstract::Obesity is a major cause for a spectrum of metabolic syndrome-related diseases that include insulin resistance, type 2 diabetes, and steatosis of the liver. Inflammation elicited by macrophages and other immune cells contributes to the metabolic abnormalities in obesity. In addition, coagulation activation following t...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-11-0068
更新日期:2015-01-01 00:00:00
abstract::Cardiovascular disease is the major cause of morbidity and mortality in subjects suffering from diabetes mellitus. While coronary artery disease is the leading cause of cardiac complications in diabetics, it is widely recognized that diabetes increases the risk for the development of heart failure independently of cor...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-09-0038
更新日期:2015-01-01 00:00:00
abstract:UNLABELLED:Clot waveform analysis extends the interpretation of aPTT measurement curves. The curve is mathematically processed to obtain information about fibrin formation kinetics including semiquantitative determination of thrombin, prothrombinase and tenase activity. PATIENTS, METHOD:In this study the feasibility o...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.5482/HAMO-14-02-0016
更新日期:2014-01-01 00:00:00
abstract::This case report concerns a pregnant multipara (age: 27 years) in the 16th gestational week. She developed a sudden onset of paraesthesia in her left lower arm although injecting dalteparin 5000 IU once daily subcutaneously (s. c.) due to a heterozygous factor V Leiden mutation and a prior miscarriage in the first pre...
journal_title:Hamostaseologie
pub_type: 杂志文章
doi:10.5482/HAMO-14-03-0022
更新日期:2014-01-01 00:00:00
abstract::Hermansky-Pudlak syndrome (HPS) is a rare, autosomal recessive disorder affecting lysosome-related organelles (LRO), including dense platelet granules. HPS causes oculocutaneous hypopigmentation, bleeding diathesis and granulomatous colitis or pulmonary fibrosis. To date, there is no curative treatment and the clinica...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-14-06-0024
更新日期:2014-01-01 00:00:00
abstract::Current antithrombotic therapy in patients with acute coronary syndrome (ACS) comprises antiplatelet and anticoagulant therapy. Dual antiplatelet therapy composed of aspirin plus a third generation P2Y12 inhibitor (prasugrel or ticagrelor) represents the gold standard, while aspirin plus second generation P2Y12 inhibi...
journal_title:Hamostaseologie
pub_type: 杂志文章,评审
doi:10.5482/HAMO-13-09-0048
更新日期:2014-01-01 00:00:00