How I Manage Thrombotic/Thromboembolic Complications in Myeloproliferative Neoplasms.

abstract：:Platelet and coagulation factor-dependent thrombus formation is critical to limit posttraumatic blood loss at sites of vascular injury. However, under pathological conditions like rupture of an atherosclerotic plaque, it may also lead to vessel occlusion causing myocardial infarction or stroke. Therefore, antithrombot...

journal_title：Hamostaseologie

authors： Hagedorn I,Vögtle T,Nieswandt B

更新日期：2010-08-01 00:00:00

abstract：:Several challenges arise from the wide application of molecular genetic analyses, among them the need to introduce rules to evaluate molecular genetic test systems as well as test laboratories. This article specifically addresses laboratories performing molecular genetic tests for diagnosis, prevention and therapy of ...

journal_title：Hamostaseologie

authors： Mannhalter C

更新日期：2010-05-01 00:00:00

abstract：:Patients suffering from haemophilia encounter various phases in life, in which individual needs, life situations, and self- and disease perception change rapidly. One of these phases spans from the beginning of puberty until early adulthood, in which individuals gain self-responsibility and reach independence and auto...

journal_title：Hamostaseologie

authors： Bidlingmaier C,Olivieri M,Schilling FH,Kurnik K,Pekrul I

更新日期：2020-02-01 00:00:00

abstract：:A survey is given on the clinical important haemostatic facts and diseases in gynaecology and obstetrics from the viewpoint of the gynecologist and obstetrician. ...

journal_title：Hamostaseologie

authors： Heilmann L

更新日期：2004-11-01 00:00:00

abstract：:Unexplained intraoperative coagulopathies continue to be a diagnostic and therapeutic dilemma. The pathophysiology behind unexplained intraoperative coagulopathies is of great variety and complexity (preexisting coagulopathies, dilutional coagulopathy, interactions of medications etc.). We have shown in prospective st...

journal_title：Hamostaseologie

authors： Korte W

更新日期：2006-08-01 00:00:00

abstract：:Trauma-induced coagulopathy (TIC) is a heterogeneous entity that contributes to a significant morbidity and mortality following trauma. The activated protein C system, endotheliopathy and platelet dysfunction have been implicated in the pathogenesis of TIC, although there are still controversies on the exact pathogene...

journal_title：Hamostaseologie

authors： Petros S

更新日期：2019-02-01 00:00:00

abstract：:Acquired haemophilia A (AHA) is a rare autoimmune disease caused by antibodies directed against clotting factor VIII. About half of cases are idiopathic, but AHA may also be secondary to autoimmune, dermatologic, or oncologic diseases. In approximately 10% of non-idiopathic cases, the disease occurs after or with the ...

journal_title：Hamostaseologie

authors： Pacholczak R,Bazan-Socha S,Zdziarska J,Iwaniec T,Walocha JA,Musiał J,Dropiński J

更新日期：2019-02-01 00:00:00

abstract：:Recombinant interleukin-2 (rIL-2) is indicated for metastatic renal cell carcinoma and melanoma. Over recent years low-dose rIL-2 has been studied for the treatment of autoimmune diseases and acute coronary syndrome because of its ability to expand and activate T regulatory (Treg) cells. However, several medical condi...

journal_title：Hamostaseologie

authors： Mahmoudpour SH,Valerio L,Douxfils J,Mahan CE,Jankowski M,Quitzau K,Konstantinides SV,Barco S

更新日期：2020-12-01 00:00:00

abstract：UNLABELLED:Atherosclerosis is a chronic inflammatory disease of the vascular wall that results from disturbed lipoprotein metabolism and increased oxidative stress. A major consequence of this is lipid peroxidation, which generates a number of breakdown products of membrane lipids that form so called oxidation-specific...

journal_title：Hamostaseologie

authors： Bartolini Gritti B,Binder CJ

更新日期：2016-05-10 00:00:00

abstract：INTRODUCTION: Regular visits at haemophilia treatment centres (HTCs) in rural regions are often dependent on the access to a private car due to lack of or limited availability of public means. Therefore, a mobile haemophilia outpatient care (MHOC) concept providing home visits to haemophilia patients has been developed...

journal_title：Hamostaseologie

authors： Eichler H,Schleicher C,Heine S,Graf N,von Mackensen S

更新日期：2018-08-01 00:00:00

abstract：:Haemophilic arthropathy is a complex multifactorial disorder that poses significant challenges to both the treating haematologist and arthroplasty surgeon. Its pathogenesis is incompletely understood. Recent literature has concentrated on the toxic effects of iron and the characteristic inflammatory synovitis. Discuss...

journal_title：Hamostaseologie

authors： Wharton R,Austin S,Back D

更新日期：2017-01-01 00:00:00

abstract：:Recombinant activated factor VII (rFVIIa) is a pro-haemostatic agent that can be used for patients with haemophilia and inhibiting antibodies towards a coagulation factor. Recombinant factor VIIa is, however, increasingly used for several other indications, including patients who experience serious and life-threatenin...

journal_title：Hamostaseologie

authors： Levi M

更新日期：2009-01-01 00:00:00

abstract：:Coronary heart disease and stroke, the deadliest forms of cardiovascular disease (CVD), are mainly caused by atherosclerosis, a chronic inflammatory disease of the artery wall driven by maladaptive immune responses in the vessel wall. Various risk factors for CVD influence this pathogenic process, including diabetes m...

journal_title：Hamostaseologie

authors： Polyzos KA,Ketelhuth DF

更新日期：2015-01-01 00:00:00

abstract：:The occurrence of cerebral or retinal ischemic symptoms ipsilateral to high-grade internal carotid artery (ICA) stenosis indicates a status of instability with a substantial risk for future major stroke. Additionally, the detection of microembolic signals downstream of ICA stenosis is predictive for future cerebral is...

journal_title：Hamostaseologie

authors： Sitzer M,Trostdorf F

更新日期：2003-05-01 00:00:00

abstract：:Clinically overt, preoperative, disseminated intravascular coagulation (DIC) is not common in patient with aortic aneurysm. However, cases with large and expanding aneurysm are especially prone for this coagulopathy. Contrary to the clinically overt form compensated DIC in patients with aortic aneurysm seems frequent ...

journal_title：Hamostaseologie

authors： Jeleńska MM

更新日期：2004-08-01 00:00:00

abstract：:Recent advances in the diagnosis and the treatment of acute coronary syndromes (ACS) have led to a substantial reduction of major coronary events, to an improvement in patient outcome and the definition of new guidelines. Current strategies for the treatment of patients with non-ST-elevation ACS recommend a combined a...

journal_title：Hamostaseologie

authors： Hölschermann H

更新日期：2007-12-01 00:00:00

abstract：:Epidemiological studies revealed that most antineoplastic agents and regimes enhance the risk of venous and arterial thromboembolic events in cancer patients. The purpose of this article is to review clinical and pathophysiological data related to chemotherapy-associated thromboembolism under special consideration of ...

journal_title：Hamostaseologie

authors： Lechner D,Weltermann A

更新日期：2009-01-01 00:00:00

abstract：:Recurrent venous thromboembolism is associated with increased mortality in 5-9% of the patients. On the other hand prolonged anticoagulation can increase the bleeding risk which can also be responsible for an increased mortality. Therefore, it is necessary to validate the recurrence risk of venous thromboembolism on a...

journal_title：Hamostaseologie

authors： Lindhoff-Last E

更新日期：2011-02-01 00:00:00

abstract：:Placenta-mediated pregnancy complications are clinically important conditions and include preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss. Pathophysiology is complex, and may be linked to prothrombotic disorders such as antiphospholipid syndrome, whose understanding is still evo...

journal_title：Hamostaseologie

authors： Skeith L,Blondon M,Ní Áinle F

更新日期：2020-08-01 00:00:00

abstract：:Nearly every second patient, who needs an oral anticoagulation with vitamin K antagonists, is feasible to perform INR-self-management after participation in a structured teaching program. Patient self-testing or measuring the INR value by relatives or nurses would increase this method of control by the aid of telemedi...

journal_title：Hamostaseologie

authors： Völler H,Braun S

更新日期：2008-10-01 00:00:00

abstract：UNLABELLED:The doses of these drugs are barely tested and the potential clinical thromboembolic risk must be taken into account. Despite the widespread use of NOAC (non vitamin-K dependent oral anticoagulants) and recommendations of regulatory agencies and first consensus meeting on handling the bleeding situation unde...

journal_title：Hamostaseologie

authors： Koscielny J,Rutkauskaite E

更新日期：2015-01-01 00:00:00

abstract：:Children with an unexplained bleeding tendency are frequently referred to a haemostaseologist for further evaluation. Careful standardized history taking and clinical evaluation should allow for distinguishing bleeds after minor injury and trauma which are very common in all children. However, in two groups of childre...

journal_title：Hamostaseologie

authors： Knöfler R,Streif W,Watzer-Herberth I,Hahn G,Schmidt U

更新日期：2019-02-01 00:00:00

abstract：:Methylation, CpG island, promoter, intron 1 Haemophilia A is the most common X-linked inherited coagulation disorder caused by a deficiency of the factor VIII protein (FVIII). A plethora of different mutations in the factor VIII gene (F8) have been identified as causative for this bleeding disease including a few prom...

journal_title：Hamostaseologie

authors： Zimmermann MA,Hansmann T,Haaf T,Oldenburg J,Müller CR,Rost S

更新日期：2013-01-01 00:00:00

abstract：:Platelet number or function disorders cause a range of bleeding symptoms from mild to severe. Patients with platelet dysfunction but normal platelet number are the most prevalent and typically have mild bleeding symptoms. The study of this group of patients is particularly difficult because of the lack of a gold-stand...

journal_title：Hamostaseologie

authors： Watson S,Daly M,Dawood B,Gissen P,Makris M,Mundell S,Wilde J,Mumford A

更新日期：2010-01-01 00:00:00

abstract：:Current antithrombotic therapy in patients with acute coronary syndrome (ACS) comprises antiplatelet and anticoagulant therapy. Dual antiplatelet therapy composed of aspirin plus a third generation P2Y12 inhibitor (prasugrel or ticagrelor) represents the gold standard, while aspirin plus second generation P2Y12 inhibi...

journal_title：Hamostaseologie

authors： Ahrens I,Bode C,Zirlik A

更新日期：2014-01-01 00:00:00

abstract：:Atherosclerosis and its sequelae have a major impact on morbidity and mortality. The rupture of an inflamed atherosclerotic plaque is a crucial event, since it can result in acute thrombotic closure of an arterial vessel, resulting e. g. in myocardial infarction or stroke. Not only detection of early plaque rupture wi...

journal_title：Hamostaseologie

authors： von Zur Muhlen C,Bode C

更新日期：2015-01-01 00:00:00

abstract：:Cardiovascular and especially thrombotic diseases remain a major cause of morbidity and mortality worldwide. In past years, significant improvements in understanding disease processes, risk assessment, and prediction of clinical outcome in the field of thrombosis and haemostasis have been made by using large-scale bio...

journal_title：Hamostaseologie

authors： Panova-Noeva M,Eggebrecht L,Prochaska JH,Wild PS

更新日期：2019-06-01 00:00:00

abstract：:Three selected casuistic studies of individual patient problems from my long-standing professional experience are presented. I intend to highlight the potential contribution of case studies, including new approaches of laboratory investigation, for the advancement of pathophysiological knowledge and would encourage to...

journal_title：Hamostaseologie

authors： Lämmle B

更新日期：2020-11-01 00:00:00

abstract：:An understanding of reversal strategies alone is important to safely and effectively care for patients in cases of bleeding or invasive procedures. The recent diversification in the number of licensed anticoagulants makes an understanding of drug-specific reversal strategies essential. Intravenous or oral vitamin K ca...

journal_title：Hamostaseologie

authors： Koscielny J,Rutkauskaite E,Sucker C,von Heymann C

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE: This article aims to analyze the phenotype and genotype of an inherited dysfibrinogenemia pedigree associated with a heterozygous mutation in the FGA gene, and to investigate the pathogenesis of this disease. CLINICAL PRESENTATION: The proband of interest is a 29-year-old woman. She was in her 37 weeks of g...

journal_title：Hamostaseologie

authors： Li S,Wang M,Li X,Xu Q,Liu S,Luo S,Chen Y

更新日期：2020-12-01 00:00:00