Clinical Problem Solving and Using New Paths in the Laboratory: Learning from Case Studies.

abstract：UNLABELLED:Clinical expression of inadequately treated haemophilia is dominated by orthopedic complications, requiring invasive or non-invasive interventions. OBJECTIVE:In Romania, with under dosed and late introduced "on demand" substitution, we aimed at highlighting the experience of orthopedic treatment and its out...

journal_title：Hamostaseologie

authors： Serban M,Mihailov MD,Poenaru D,Pop L,Branea I,Bataneant M,Lăcătuşu A,Barna L,Tepeneu N,Schramm W

更新日期：2008-10-01 00:00:00

abstract：:Platelet and coagulation factor-dependent thrombus formation is critical to limit posttraumatic blood loss at sites of vascular injury. However, under pathological conditions like rupture of an atherosclerotic plaque, it may also lead to vessel occlusion causing myocardial infarction or stroke. Therefore, antithrombot...

journal_title：Hamostaseologie

authors： Hagedorn I,Vögtle T,Nieswandt B

更新日期：2010-08-01 00:00:00

abstract：:Recombinant interleukin-2 (rIL-2) is indicated for metastatic renal cell carcinoma and melanoma. Over recent years low-dose rIL-2 has been studied for the treatment of autoimmune diseases and acute coronary syndrome because of its ability to expand and activate T regulatory (Treg) cells. However, several medical condi...

journal_title：Hamostaseologie

authors： Mahmoudpour SH,Valerio L,Douxfils J,Mahan CE,Jankowski M,Quitzau K,Konstantinides SV,Barco S

更新日期：2020-12-01 00:00:00

abstract：:Current antithrombotic therapy in patients with acute coronary syndrome (ACS) comprises antiplatelet and anticoagulant therapy. Dual antiplatelet therapy composed of aspirin plus a third generation P2Y12 inhibitor (prasugrel or ticagrelor) represents the gold standard, while aspirin plus second generation P2Y12 inhibi...

journal_title：Hamostaseologie

authors： Ahrens I,Bode C,Zirlik A

更新日期：2014-01-01 00:00:00

abstract：:We describe the case of a 30-year-old woman with homozygous prothrombin G20210A transition and heterozygous FV Leiden mutation and a history of postpartum venous thrombosis. Despite the high thrombotic risk to be assumed in the presence of this combined thrombophilia our patient suffered her first venous thrombotic ev...

journal_title：Hamostaseologie

authors： Mengis C,Demarmels Biasiutti F

更新日期：2003-08-01 00:00:00

abstract：UNLABELLED:Antibodies against annexin-V, a potent anticoagulant abundant in placental tissues, were recently controversially reported to be associated with recurrent miscarriages or failures of in-vitro-fertilization (IVF) attempts. PATIENTS, MATERIAL, METHODS:We screened 56 women (34.7 +/- 4.3 years of age: mean +/- ...

journal_title：Hamostaseologie

authors： Halbmayer WM,Feichtinger W,Kindermann C,Prendinger B,Böhm M

更新日期：2005-11-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) has occupied haemostaseologists, rheumatologists and obstetricians since its initial description 35 years ago. Its name has been coined because of the antibodies against phospholipids which were the common property of affected patients. In particular, the pathogenesis of APS has bee...

journal_title：Hamostaseologie

authors： Lackner KJ,Müller-Calleja N

更新日期：2019-06-01 00:00:00

abstract：UNLABELLED:Atherosclerosis is a chronic inflammatory disease of the vascular wall that results from disturbed lipoprotein metabolism and increased oxidative stress. A major consequence of this is lipid peroxidation, which generates a number of breakdown products of membrane lipids that form so called oxidation-specific...

journal_title：Hamostaseologie

authors： Bartolini Gritti B,Binder CJ

更新日期：2016-05-10 00:00:00

abstract：:Superficial vein thrombosis (SVT) is a common disease, characterized by an inflammatory-thrombotic process in a superficial vein. Typical clinical findings are pain and a warm, tender, reddish cord along the vein. Until recently, no reliable epidemiological data were available. The incidence is estimated to be higher ...

journal_title：Hamostaseologie

authors： Bauersachs RM

更新日期：2013-08-01 00:00:00

abstract：:Patients with myeloproliferative neoplasms (MPNs), such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are at increased risk for arterial and venous thrombosis/thromboembolism. In particular, the risk of splanchnic venous thrombosis, such as portal vein thrombosis or Budd-Chiari syndrome, ...

journal_title：Hamostaseologie

authors： Koschmieder S

更新日期：2020-02-01 00:00:00

abstract：UNLABELLED:With the development of clotting-factors in the seventies the haemophilia patients were released from being handicapped and began to live a quite normal life. Thus, psychosocial counselling did not seem to be necessary. But the impact of HIV-infection to the world of haemophilia was so intense that professio...

journal_title：Hamostaseologie

authors： Schneider MM,Schramm W

更新日期：2010-11-01 00:00:00

abstract：:Upon vascular injury or tissue damage, the exposed intracellular material such as nucleic acids, histones and other macromolecules may come into contact with vessel wall cells and circulating blood cells and may thus, have an enduring influence on wound healing and body defence processes. This short review summarizes ...

journal_title：Hamostaseologie

authors： Fischer S,Preissner KT

更新日期：2013-01-01 00:00:00

abstract：:In Germany one-third of the women in fertile age use combined oral contraceptives (COCs), which consist mostly of ethinylestradiol (EE) and a synthetic progestin. Older COCs with norethisterone or levonorgestrel have a lower risk for venous thromboembolism (VTE) than newer COCs with desogestrel, drospirenone, or gesto...

journal_title：Hamostaseologie

authors： Rott H

更新日期：2019-02-01 00:00:00

abstract：:This article reviews the roles of blood platelets in haemostasis as well as in the pathogenesis of thromboembolic diseases. Besides the basic processes in primary haemostasis, platelet adhesion, platelet secretion, platelet aggregation, clot retraction, the new model of thrombin formation on the platelet surface is pr...

journal_title：Hamostaseologie

authors： Kehrel BE

更新日期：2008-12-01 00:00:00

abstract：:Patients suffering from haemophilia encounter various phases in life, in which individual needs, life situations, and self- and disease perception change rapidly. One of these phases spans from the beginning of puberty until early adulthood, in which individuals gain self-responsibility and reach independence and auto...

journal_title：Hamostaseologie

authors： Bidlingmaier C,Olivieri M,Schilling FH,Kurnik K,Pekrul I

更新日期：2020-02-01 00:00:00

abstract：:A survey is given on the clinical important haemostatic facts and diseases in gynaecology and obstetrics from the viewpoint of the gynecologist and obstetrician. ...

journal_title：Hamostaseologie

authors： Heilmann L

更新日期：2004-11-01 00:00:00

abstract：:Cardiovascular and especially thrombotic diseases remain a major cause of morbidity and mortality worldwide. In past years, significant improvements in understanding disease processes, risk assessment, and prediction of clinical outcome in the field of thrombosis and haemostasis have been made by using large-scale bio...

journal_title：Hamostaseologie

authors： Panova-Noeva M,Eggebrecht L,Prochaska JH,Wild PS

更新日期：2019-06-01 00:00:00

abstract：:Trauma-induced coagulopathy (TIC) is a heterogeneous entity that contributes to a significant morbidity and mortality following trauma. The activated protein C system, endotheliopathy and platelet dysfunction have been implicated in the pathogenesis of TIC, although there are still controversies on the exact pathogene...

journal_title：Hamostaseologie

authors： Petros S

更新日期：2019-02-01 00:00:00

abstract：:For the last decades, anticoagulation for stroke prevention in atrial fibrillation (AF) as well as for the prophylaxis and long-term treatment of venous thromboembolism has been entirely based on vitamin K antagonists (VKA). Although very effective under optimal conditions, long-term treatment with these drugs is flaw...

journal_title：Hamostaseologie

authors： Steffel J,Luscher TF

更新日期：2012-01-01 00:00:00

abstract：:Myocardial infarction (MI) shows a strong heritability. For a long time the identification of responsible genes has been rather unsuccessful. However, with the advent of genome wide association studies (GWAS) using DNA-array technology a number of significant loci for MI have been identified which were widely replicat...

journal_title：Hamostaseologie

authors： Linsel-Nitschke P,Erdmann J,Schunkert H

更新日期：2010-11-01 00:00:00

abstract：:Von Willebrand disease (VWD) is known for its marked heterogeneity which was already recognized by von Willebrand in 1926. The basis of phenotypic differentiation are quantitative and qualitative or functional differences between the different types and subtypes of VWD. One of the most important tools in the classific...

journal_title：Hamostaseologie

authors： Schneppenheim R,Budde U

更新日期：2004-02-01 00:00:00

abstract：UNLABELLED:The doses of these drugs are barely tested and the potential clinical thromboembolic risk must be taken into account. Despite the widespread use of NOAC (non vitamin-K dependent oral anticoagulants) and recommendations of regulatory agencies and first consensus meeting on handling the bleeding situation unde...

journal_title：Hamostaseologie

authors： Koscielny J,Rutkauskaite E

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:In recent years thrombophilia has gained much attention as a risk factor for pregnancy complications. Whereas there is an established correlation between antiphospholipid-antibodies and pregnancy loss, data for other risk factors of thrombosis are less well established. Data suggest associations with antithr...

journal_title：Hamostaseologie

authors： Pabinger I

更新日期：2008-01-01 00:00:00

abstract：:Nutrient excess in obesity drives metabolic reprogramming in multiple tissues involving extensive interorgan and intercellular crosstalk. Experimental and clinical studies show that prolonged nutrient excess often compromises metabolic adaptation propagating proobesogenic and proinflammatory responses. Chronic inflamm...

journal_title：Hamostaseologie

authors： Madhusudhan T,Ruf W

更新日期：2019-06-01 00:00:00

abstract：:An overview is given on congenital and acquired thrombocytopenias, their pathophysiology, symptoms, diagnosis and therapy with emphasizing heparin-induced thrombocytopenia (HIT) and the thrombotic thrombocytopenic purpura (TTP). ...

journal_title：Hamostaseologie

authors： Scharf RE

更新日期：2003-11-01 00:00:00

abstract：:Platelet cytoskeletal reorganization is essential for platelet adhesion and thrombus formation in hemostasis and thrombosis. The Rho GTPases RhoA, Rac1 and Cdc42 are the main players in cytoskeletal dynamics of platelets responsible for the formation of filopodia and lamellipodia to strongly increase the platelet surf...

journal_title：Hamostaseologie

authors： Elvers M

更新日期：2016-08-03 00:00:00

abstract：:Placenta-mediated pregnancy complications are clinically important conditions and include preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss. Pathophysiology is complex, and may be linked to prothrombotic disorders such as antiphospholipid syndrome, whose understanding is still evo...

journal_title：Hamostaseologie

authors： Skeith L,Blondon M,Ní Áinle F

更新日期：2020-08-01 00:00:00

abstract：:Thrombocytosis (defined as platelets >450 x 109/l) has several aetiologies. After having excluded spurious thrombocytosis (e. g., due to microspherocytes, schistocytes, cryoglobulins, or bacteria), the differential diagnosis of true thrombocytosis encompasses secondary causes (as diverse as inflammation, infection, ma...

journal_title：Hamostaseologie

authors： Alberio L

更新日期：2016-11-07 00:00:00

abstract：:The occurrence of cerebral or retinal ischemic symptoms ipsilateral to high-grade internal carotid artery (ICA) stenosis indicates a status of instability with a substantial risk for future major stroke. Additionally, the detection of microembolic signals downstream of ICA stenosis is predictive for future cerebral is...

journal_title：Hamostaseologie

authors： Sitzer M,Trostdorf F

更新日期：2003-05-01 00:00:00

abstract：:Several challenges arise from the wide application of molecular genetic analyses, among them the need to introduce rules to evaluate molecular genetic test systems as well as test laboratories. This article specifically addresses laboratories performing molecular genetic tests for diagnosis, prevention and therapy of ...

journal_title：Hamostaseologie

authors： Mannhalter C

更新日期：2010-05-01 00:00:00