abstract：:Point of Care Testing (POCT) refers to clinical laboratory testing performed outside the central laboratory, nearer to the patient and sometimes at the patient bedside. The testing is usually performed by clinical staff, such as physicians or nurses, who are not laboratory trained. This document was developed by the P...

journal_title：Clinical biochemistry

authors： Venner AA,Beach LA,Shea JL,Knauer MJ,Huang Y,Fung AWS,Dalton J,Provencal M,Shaw JLV

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVES:All patients who undergo cardiopulmonary bypass (CPB) experience some degree of ischemia reperfusion injury (IRI). Severe IRI-induced acute kidney injury (AKI) occurs in approximately 1-2% of patients undergoing CPB. Previous studies using activity-based protein profiling of urine identified group XV phospho...

journal_title：Clinical biochemistry

authors： Navarrete M,Wilkins JA,Chan FV,Ye B,Nickerson P,Ho J

更新日期：2021-02-01 00:00:00

abstract：:The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spread all over the world rapidly and caused a global pandemic. To prevent the virus from spreading to more individuals, it is of great importance to identify and isolate infected individuals through testing. Reverse transcription-quanti...

journal_title：Clinical biochemistry

authors： Palaz F,Kalkan AK,Tozluyurt A,Ozsoz M

更新日期：2021-01-09 00:00:00

abstract：OBJECTIVE:The relationship between the severity of atherosclerotic coronary artery disease (CAD) and circulating levels of salusin-α, salusin-β and heregulin-β1 has been investigated. In addition, the relationship with these peptides and high sensitive C-reactive protein (hsCRP) has been investigated. METHODS:The stud...

journal_title：Clinical biochemistry

authors： Arkan A,Atukeren P,Ikitimur B,Simsek G,Koksal S,Gelisgen R,Ongen Z,Uzun H

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:Gaucher disease (GD) is caused by a deficiency of β-glucosidase (GCase), leading to accumulation of glucosylceramide (GlcC) and glucosylsphingosine (Lyso-Gb1). Lyso-Gb1 is a reliable biomarker for GD. OBJECTIVES:This study aims to develop a simple, effective and accurate method for the screening and diagn...

journal_title：Clinical biochemistry

authors： Tang C,Jia X,Tang F,Liu S,Jiang X,Zhao X,Sheng H,Peng M,Liu L,Huang Y

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVES:Humoral immune response to SARS-CoV-2 infection has been reported in several patient cohorts with results that vary by method and population studied due to the lack of reliable commercial assays available as the pandemic initially spread. We sought to clinically assess commercial prototype SARS-CoV-2 IgG and...

journal_title：Clinical biochemistry

authors： Wheeler SE,Shurin GV,Keetch C,Mitchell G,Kattel G,McBreen J,Shurin MR

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Researchers are debating if fecal calprotectin results are useful for infant patients, especially in screening for necrotizing enterocolitis (NEC). Currently, none of the FDA-approved calprotectin assays provide a cut-off for infant patients. We retrospectively analyzed data from a reference laboratory and u...

journal_title：Clinical biochemistry

authors： Goold E,Pearson L,Johnson LM

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Given that both insufficient and excess maternal iodine have adverse consequences such as poor cognitive performance, delayed physical development and increased fetal and infant mortality, the determination of maternal iodine status is very important. In this study, we established and verified a method invol...

journal_title：Clinical biochemistry

authors： Zou Y,Wang D,Yu S,Cheng X,Xia L,Yin Y,Xie S,Cheng Q,Qiu L,Lian X

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Laboratory confirmation of alpha-1-antitrypsin (A1AT) deficiency may be achieved by multiple methods. Here, we compare the relative comprehensiveness and efficiency of pathogenic variant (PV) detection of four different protocols utilized at different diagnostic centres in Canada. METHODS:Diagnostic results...

journal_title：Clinical biochemistry

authors： Mattman A,Gilfix BM,Chen SX,DeMarco ML,Kyle BD,Parker ML,Agbor TA,Jung B,Selvarajah S,Barakauskas VE,Vaags AK,Estey MP,Nelson TN,Speevak MD

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Cardiac troponins (cTn) are essential in the diagnostic assessment of non-ST-segment-elevation acute coronary syndrome (NSTE-ACS). Elevated concentrations of cTnT and cTnI predict cardiovascular events in non-acute settings, but the individual troponin isotype association with long-term mortality in patients...

journal_title：Clinical biochemistry

authors： Tveit SH,Myhre PL,Hoff NJS,Le TM,Seljeflot I,Røysland R,Høiseth AD,Røsjø H,Omland T

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:The avoidance of repeat chemistry testing such as Complete Blood Count (CBC) and Electrolyte Panel (EP) on clinically stable patients was identified as important utilization goals by Choosing Wisely Canada. The purpose of this study was to assess the volume of overutilization of CBC and EP in an inpatient ...

journal_title：Clinical biochemistry

authors： Kandalam V,Lau CK,Guo M,Ma I,Naugler C

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Increased levels of circulating endostatin predicts cardiovascular morbidity and impaired kidney function in the general population. The utility of endostatin as a risk marker for mortality in the emergency department (ED) has not been reported. AIM:Our main aim was to study the association between plasma e...

journal_title：Clinical biochemistry

authors： Carlsson AC,Wessman T,Larsson A,Leijonberg G,Tofik R,Ärnlöv J,Melander O,Ruge T

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is one of the most common cancers worldwide, and emerging lines of evidence have implicated circular RNAs (circRNAs), a novel class of endogenous noncoding RNAs, in CRC development. However, whether plasma circRNAs might be novel diagnostic biomarkers for CRC remains unclear. METHODS...

journal_title：Clinical biochemistry

authors： Lin J,Cai D,Li W,Yu T,Mao H,Jiang S,Xiao B

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:We aimed to establish correlations for the levels of follicle-stimulating hormone (FSH), estrone (E1) and estradiol (E2) between urine and serum in premenopausal and postmenopausal women using immunoassays. METHODS:In this study of 92 women (61 postmenopausal, 31 premenopausal), both urine and blood specimen...

journal_title：Clinical biochemistry

authors： Onizuka Y,Nagai K,Ideno Y,Kitahara Y,Iwase A,Yasui T,Nakajima-Shimada J,Hayashi K

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Reference intervals have traditionally been partitioned by age based on statistical significance and physiological relevance. However, analyte concentration does not change abruptly with age, but rather dynamically. In this study, we establish biochemical marker continuous reference intervals for a Canadian ...

journal_title：Clinical biochemistry

authors： Asgari S,Higgins V,McCudden C,Adeli K

更新日期：2019-11-01 00:00:00

abstract：:Core Alzheimer's Disease (AD) biomarkers are the cerebrospinal fluid (CSF) proteins amyloid β42 and β40, and the tau proteins, total and phosphorylated. Their use is recommended by research guidelines for diagnostic purpose and for stratification of patients for clinical trials. However, novel potential biomarkers are...

journal_title：Clinical biochemistry

authors： Sancesario G,Bernardini S

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The clinical laboratory is responsible for reporting accurate and expeditious results. However, the pre-analytical phase is directly related to the procedure of specimen collection and is mostly out of the direct control of the laboratory; further, most pre-analytical errors are related to human factors. The...

journal_title：Clinical biochemistry

authors： Lee NY

更新日期：2019-08-01 00:00:00

abstract：OBJECTIVE:To develop a tool to assess the clinical accuracy of glucose meter performance using an insulin dosing protocol to assess the frequency and extent of error in insulin dose categories. METHODS:Retrospective comparison of 1815 glucose meter and central laboratory glucose results obtained from 1698 critically i...

journal_title：Clinical biochemistry

authors： Lyon ME,Lyon OAS,Tran NK,DuBois JA,Lyon AW

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Myocardial infarction (MI) is more likely if the heart damage biomarker cardiac troponin T (cTnT) is elevated in a blood sample from a patient with chest pain. There is no conventional method to estimate the risk of MI at a specific cTnT concentration. The purpose of this study was to evaluate the performanc...

journal_title：Clinical biochemistry

authors： Ognissanti D,Bjurman C,Holzmann MJ,Theodorsson E,Petzold M,Cvijovic M,Hammarsten O

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:To increase the accuracy of non-invasive diagnosis of nonalcoholic fatty liver disease (NAFLD), clinical and laboratory NAFLD indicators were integrated into a diagnostic formula. METHODS:A total of 141 patients with clinically diagnosed NAFLD and 30 healthy controls were enrolled. We collected case history,...

journal_title：Clinical biochemistry

authors： Feng G,He N,Zhou YF,Li XP,Niu C,Liu ML,Zhang KL,Li Y,Li YM,Zheng MH,Mi M

更新日期：2019-02-01 00:00:00

abstract：CONTEXT:Knee arthroplasty surgery is significant trauma, leading to an activated immune system causing inflammation and oxidative stress. Many current biomarkers are invasive, costly, and often slow to analyse, limiting their use for rapid inflammatory measurements. OBJECTIVES:We have examined the use of urinary neopt...

journal_title：Clinical biochemistry

authors： Baxter-Parker G,Roffe L,Cross S,Frampton C,Hooper GJ,Gieseg SP

更新日期：2019-01-01 00:00:00

abstract：:Steroids play an important role in sperm production and quality. These hormones have been extensively studied in blood, but poorly investigated in semen. The purpose of our study was to evaluate the relationship between sperm quality and steroid profiles in blood and semen in a small cohort of young Swiss men. Another...

journal_title：Clinical biochemistry

authors： Zufferey F,Rahban R,Garcia A,Gagnebin Y,Boccard J,Tonoli D,Jeanneret F,Stettler E,Senn A,Nef S,Rudaz S,Rossier MF

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:Molecular screening plays a major role in prognostic categorization and subsequent definition of treatment strategies for acute myeloid leukemia. The possibility of using IDH1/2 mutations as a marker for the monitoring of minimal residual disease (MRD) is still under investigation and remains unclear. METHO...

journal_title：Clinical biochemistry

authors： Petrova L,Vrbacky F,Lanska M,Zavrelova A,Zak P,Hrochova K

更新日期：2018-11-01 00:00:00

abstract：:Fibroblast growth factor 23 (FGF-23), a key hormone for the regulation of the phosphorus homeostasis, has also several direct effects on cardiac function. In heart failure (HF), the increase of FGF-23 participates to cardiac hypertrophy and remodeling. Measurement of the intact, biologically active hormone is now avai...

journal_title：Clinical biochemistry

authors： Gruson D,Carbone V,Feracin B,Ahn SA,Rousseau MF

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:A multisite investigation compared the analytical performance of a point-of-care (POC) HbA1c device with multiple commonly used HbA1c laboratory methods and an NGSP (National Glycohemoglobin Standardization Program) reference method. RESEARCH DESIGN AND METHODS:The Afinion AS100 POC device analyzed HbA1c usi...

journal_title：Clinical biochemistry

authors： Sobolesky PM,Smith BE,Saenger AK,Schulz K,Apple FS,Scott MG,Wu AHB,Little RR,Fitzgerald RL

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:Non-invasive prenatal aneuploidy testing (NIPT) by next-generation sequencing of circulating cell-free DNA in maternal plasma relies on chromosomal ratio (chrratio) measurements to detect aneuploid values that depart from euploid ratios. Diagnostic performances are known to depend on the fraction of fetal DN...

journal_title：Clinical biochemistry

authors： Blais J,Giroux S,Caron A,Clément V,Dionne-Laporte A,Jouan L,Gauthier J,MacLeod T,Moore R,Parker J,Swanson L,Zhao Y,Rouleau G,Karsan A,Langlois S,Rousseau F

更新日期：2018-09-01 00:00:00

abstract：:Osteopontin (OPN) is a highly phosphorylated glycophosphoprotein having acidic characteristics and rich in aspartic acid. OPN, a multifunctional protein, has important functions on cardiovascular diseases, cancer, diabetes and kidney stone diseases and in the process of inflammation, biomineralization, cell viability ...

journal_title：Clinical biochemistry

authors： Icer MA,Gezmen-Karadag M

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Several cases of biotin interference with laboratory testing have been reported in the literature. However, there are no publications discussing the extent of biotin use or plasma concentrations observed among the patient population. The objective of this study was to determine the prevalence of biotin consu...

journal_title：Clinical biochemistry

authors： Katzman BM,Lueke AJ,Donato LJ,Jaffe AS,Baumann NA

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:MicroRNA-331 (miR-331) has shown regulatory activity against several genes whose expression has been claimed to be deregulated in breast tumors, including that of epidermal growth factor receptor 2 (HER2). Herein, the clinical value of miR-331 expression was investigated by analyzing its levels in breast beni...

journal_title：Clinical biochemistry

authors： Papadopoulos EI,Papachristopoulou G,Ardavanis A,Scorilas A

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:BNP and NT-proBNP are viewed as comparable in their ability to diagnose and monitor HF in clinical guidelines. However, no recent large-scale study has directly established diagnostic concordance between BNP and NT-proBNP. This study sought to assess diagnostic concordance of BNP and NT-proBNP for ruling in ...

journal_title：Clinical biochemistry

authors： Farnsworth CW,Bailey AL,Jaffe AS,Scott MG

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:With the advent of the new high-sensitivity troponin assays, it is becoming critical to measure troponin accurately to low concentrations. To ensure assay performance is acceptable, appropriate QC must be run. METHODS:In addition to the routine use of commercial QC material, we prepared pools of human QC ma...

journal_title：Clinical biochemistry

authors： Hickman PE,Koerbin G,Badrick T,Oakman C,Potter JM

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:The new immunochemistry cobas e 801 module (Roche Diagnostics) was developed to meet increasing demands on routine laboratories to further improve testing efficiency, while maintaining high quality and reliable data. DESIGN AND METHODS:During a non-interventional multicenter evaluation study, the overall pe...

journal_title：Clinical biochemistry

authors： Findeisen P,Zahn I,Fiedler GM,Leichtle AB,Wang S,Soria G,Johnson P,Henzell J,Hegel JK,Bendavid C,Collet N,McGovern M,Klopprogge K

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Barricor™ Vacutainers® are a novel non-gel separator blood collection tube. These tubes enable faster pre-analytical processing which could reduce turnaround time and be beneficial in an acute care setting. We sought to evaluate the bias, stability, and integrity of plasma generated from these tubes compar...

journal_title：Clinical biochemistry

authors： Fournier JE,Northrup V,Clark C,Fraser J,Howlett M,Atkinson P,Shea JL

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Automatic photometric determination of the hemolysis index (HI) on serum and plasma samples is central to detect potential interferences of in vitro hemolysis on laboratory tests. When HI is above an established cut-off for interference, results may suffer from a significant bias and undermine clinical relia...

journal_title：Clinical biochemistry

authors： Aloisio E,Carnevale A,Pasqualetti S,Birindelli S,Dolci A,Panteghini M

更新日期：2018-07-01 00:00:00

abstract：:To design and deliver high quality, safe and effective products, manufacturers of in vitro diagnostic (IVD) products follow a structured, traceable process for controlling the uncertainty of results reported from their measurement systems. This process and its results however, are not often shared in detail with those...

journal_title：Clinical biochemistry

authors： Orzechowski A,Petrides V,Scopp R

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Oxidative stress is evident from an early stage in chronic kidney disease (CKD). Therefore, we investigated redox biomarkers in polycystic kidney disease (ADPKD) and IgA nephropathy (IGAN). METHODS:This is a case-control study with three groups: ADPKD (n = 54), IGAN (n = 58) and healthy controls (n = 86). T...

journal_title：Clinical biochemistry

authors： Tariq A,Mansoor MA,Marti HP,Jonsson G,Slettan A,Weeraman P,Apeland T

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:The aldosterone/renin ratio (ARR) is recommended to screen for primary aldosteronism (PA) in hypertension. We estimated fully automated chemiluminescence immunoassays (CLIA) for plasma aldosterone concentrations (PAC) and plasma direct renin concentrations (PRC) and investigated their reference intervals in ...

journal_title：Clinical biochemistry

authors： Deng L,Xiong Z,Li H,Lei X,Cheng L

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Red blood cell distribution width (RDW) is a predictor of mortality in critically ill patients. Our objective was to investigate the association between the RDW at ICU discharge and the risk of ICU readmission or unexpected death in the ward. METHODS:A secondary analysis of prospectively collected data stud...

journal_title：Clinical biochemistry

authors： Tonietto TA,Boniatti MM,Lisboa TC,Viana MV,Dos Santos MC,Lincho CS,Pellegrini JAS,Vidart J,Neyeloff JL,Faulhaber GAM

更新日期：2018-05-01 00:00:00

abstract：:Post-transplant ischemic acute kidney injury (AKI), secondary to ischemia reperfusion injury (IRI), is a major problem influencing on the short and long term graft and patient survival. Many molecular and cellular modifications are observed during IRI, for example, tissue damage result production of reactive oxygen sp...

journal_title：Clinical biochemistry

authors： Panah F,Ghorbanihaghjo A,Argani H,Asadi Zarmehri M,Nazari Soltan Ahmad S

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:To determine salivary cortisol reference intervals in a healthy adult population, at 6 different time points during a 24-hour (h) period. METHODS:In a prospective study, salivary cortisol concentrations were measured upon waking, one-hour post-waking and at specific times of the day: at 12 h00, 16 h00, 20 h...

journal_title：Clinical biochemistry

authors： Gagnon N,Fréchette I,Mallet PL,Dubé J,Houde G,Fink GD

更新日期：2018-04-01 00:00:00