Abstract:
OBJECTIVES:The new immunochemistry cobas e 801 module (Roche Diagnostics) was developed to meet increasing demands on routine laboratories to further improve testing efficiency, while maintaining high quality and reliable data. DESIGN AND METHODS:During a non-interventional multicenter evaluation study, the overall performance, functionality and reliability of the new module was investigated under routine-like conditions. It was tested as a dedicated immunochemistry system at four sites and as a consolidator combined with clinical chemistry at three sites. RESULTS:We report on testing efficiency and analytical performance of the new module. Evaluation of sample workloads with site-specific routine request patterns demonstrated increased speed and almost doubled throughput (maximal 300 tests per h), thus revealing that one cobas e 801 module can replace two cobas e 602 modules while saving up to 44% floor space. Result stability was demonstrated by QC analysis per assay throughout the study. Precision testing over 21 days yielded excellent results within and between labs, and, method comparison performed versus the cobas e 602 module routine results showed high consistency of results for all assays under study. In a practicability assessment related to performance and handling, 99% of graded features met (44%) or even exceeded (55%) laboratory expectations, with enhanced reagent management and loading during operation being highlighted. CONCLUSION:By nearly doubling immunochemistry testing efficiency on the same footprint as a cobas e 602 module, the new module has a great potential to further consolidate and enhance laboratory testing while maintaining high quality analytical performance with Roche platforms.
journal_name
Clin Biochemjournal_title
Clinical biochemistryauthors
Findeisen P,Zahn I,Fiedler GM,Leichtle AB,Wang S,Soria G,Johnson P,Henzell J,Hegel JK,Bendavid C,Collet N,McGovern M,Klopprogge Kdoi
10.1016/j.clinbiochem.2018.05.019subject
Has Abstractpub_date
2018-08-01 00:00:00pages
86-93eissn
0009-9120issn
1873-2933pii
S0009-9120(17)31130-Xjournal_volume
58pub_type
杂志文章,多中心研究abstract:OBJECTIVES:Angiotensin converting enzyme (ACE), G-Protein couple receptor (G-Prot), endothelial nitric oxide synthase (ecNOS), Leptin -2548G/A and uncoupling protein (UCP2) are potent regulators of intra renal hemodynamics and may be the causative factors contributing to the deterioration of renal functions. In recent ...
journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2008.01.009
更新日期:2008-05-01 00:00:00
abstract::The ES 300 system, a fully automated multichannel immunoassay analyzer, was evaluated simultaneously for 9 weeks in four major centers. Precision, accuracy, carryover, comparison to in-house methods, and interferences were assessed for the following 17 tests: T4, T3, FT4, TSH, TBK, TBG, LH, FSH, prolactin, HCG, digoxi...
journal_title:Clinical biochemistry
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abstract:OBJECTIVES:To develop a tandem mass spectrometry (MS/MS) method for plasma free and total carnitine, incorporating acid hydrolysis for total carnitine measurement, for improved accuracy and sample throughput. DESIGN AND METHODS:Limit of detection (LOD), limit of quantitation (LOQ), linearity, accuracy, precision coeff...
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journal_title:Clinical biochemistry
pub_type: 杂志文章
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journal_title:Clinical biochemistry
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journal_title:Clinical biochemistry
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journal_title:Clinical biochemistry
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doi:10.1016/j.clinbiochem.2007.01.010
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2004.03.009
更新日期:2004-08-01 00:00:00
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journal_title:Clinical biochemistry
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0009-9120(01)00199-0
更新日期:2001-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2012.08.024
更新日期:2012-12-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2011.04.009
更新日期:2011-07-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2007.03.009
更新日期:2007-07-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2014.01.011
更新日期:2014-05-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章,评审
doi:10.1016/j.clinbiochem.2018.07.003
更新日期:2018-09-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2009.06.006
更新日期:2009-09-01 00:00:00
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doi:10.1016/s0009-9120(98)00024-1
更新日期:1998-07-01 00:00:00
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更新日期:2014-03-01 00:00:00
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doi:10.1016/s0009-9120(00)00079-5
更新日期:2000-06-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1986-04-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2011.06.004
更新日期:2011-09-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章,多中心研究
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更新日期:2020-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1984-04-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章,评审
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更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0009-9120(80)90502-0
更新日期:1980-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0009-9120(94)90046-9
更新日期:1994-10-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2010.08.022
更新日期:2010-11-01 00:00:00