Incremental value of intact fibroblast growth factor 23 to natriuretic peptides for long-term risk estimation of heart failure patients.

Abstract:

:Fibroblast growth factor 23 (FGF-23), a key hormone for the regulation of the phosphorus homeostasis, has also several direct effects on cardiac function. In heart failure (HF), the increase of FGF-23 participates to cardiac hypertrophy and remodeling. Measurement of the intact, biologically active hormone is now available. We determined intact FGF-23 in HF patients with reduced ejection fraction and assess its prognosis value for cardiovascular death over a long-term follow-up. We observed that intact FGF-23 is an independent predictor of cardiovascular death in HF patients and provides added value to the standard of care, natriuretic peptide, for risk estimation.

journal_name

Clin Biochem

journal_title

Clinical biochemistry

authors

Gruson D,Carbone V,Feracin B,Ahn SA,Rousseau MF

doi

10.1016/j.clinbiochem.2018.09.003

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

47-49

eissn

0009-9120

issn

1873-2933

pii

S0009-9120(18)30818-X

journal_volume

61

pub_type

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