Abstract:
BACKGROUND:Researchers are debating if fecal calprotectin results are useful for infant patients, especially in screening for necrotizing enterocolitis (NEC). Currently, none of the FDA-approved calprotectin assays provide a cut-off for infant patients. We retrospectively analyzed data from a reference laboratory and university hospital to investigate if a cut-off could be established for infant patients. METHODS:Data from a national reference laboratory of 5144 test results for fecal calprotectin were analyzed for infant patients, and a cut-off was estimated based on the distribution of results. Additionally, a literature proposed cut-off of 226 μg/g was also considered. Validation of either cut-off was attempted by review of the electronic medical record of our university hospital for 110 infant patients with results for fecal calprotectin. RESULTS:Infants had a high percentage of elevated fecal calprotectin results when using the adult cut-offs set by the manufacturer. A cut-off of 247 μg/g was estimated based on the reference laboratory results for infants 0-2 months old, which is similar to a literature proposed cut-off of 226 μg/g. However, the positive predictive value (PPV) for both cut-offs was <0.6 when retrospectively analyzing data from a university hospital. CONCLUSION:Due to the low PPVs, the two infant-specific cut-offs for fecal calprotectin would not be useful to screen for NEC in infants at our university hospital.
journal_name
Clin Biochemjournal_title
Clinical biochemistryauthors
Goold E,Pearson L,Johnson LMdoi
10.1016/j.clinbiochem.2020.06.015subject
Has Abstractpub_date
2020-10-01 00:00:00pages
51-54eissn
0009-9120issn
1873-2933pii
S0009-9120(20)30782-7journal_volume
84pub_type
杂志文章abstract:BACKGROUND:Histamine (HA) is a small amine playing an important role in anaphylactic reactions. In order to identify and quantify HA in plasma matrix, different methods have been developed but present several disadvantages. Here, we developed an alternative method using liquid chromatography coupled with an ultra-high ...
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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更新日期:2008-12-01 00:00:00
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journal_title:Clinical biochemistry
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journal_title:Clinical biochemistry
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更新日期:2009-11-01 00:00:00
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journal_title:Clinical biochemistry
pub_type: 杂志文章
doi:10.1016/0009-9120(90)80032-e
更新日期:1990-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1992-04-01 00:00:00
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更新日期:2009-09-01 00:00:00
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doi:10.1016/j.clinbiochem.2006.08.013
更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.clinbiochem.2013.08.006
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0009-9120(85)80031-x
更新日期:1985-10-01 00:00:00
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更新日期:2010-12-01 00:00:00
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更新日期:2014-05-01 00:00:00
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更新日期:1980-02-01 00:00:00
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更新日期:2018-09-01 00:00:00
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更新日期:2017-01-01 00:00:00