Abstract：
:Osteopontin (OPN) is a highly phosphorylated glycophosphoprotein having acidic characteristics and rich in aspartic acid. OPN, a multifunctional protein, has important functions on cardiovascular diseases, cancer, diabetes and kidney stone diseases and in the process of inflammation, biomineralization, cell viability and wound healing. Osteopontin acts on organisms by playing a key role in secretion levels of interleukin-10 (IL-10), interleukin-12 (IL-12), interleukin-3 (IL-3), interferon-γ (IFN-γ), integrin αvB3, nuclear factor kappa B (NF-kB), macrophage and T cells, regulating the osteoclast function and affecting CD44 receptors. The aim of the present review is to address majority of different functions of OPN protein which are known, suspected or suggested through the data obtained about this protein yet.
journal_name
Clin Biochemjournal_title
Clinical biochemistryauthors
Icer MA,Gezmen-Karadag Mdoi
10.1016/j.clinbiochem.2018.07.003subject
Has Abstractpub_date
2018-09-01 00:00:00pages
17-24eissn
0009-9120issn
1873-2933pii
S0009-9120(18)30383-7journal_volume
59pub_type
杂志文章,评审abstract：:The discovery of the causal association of adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiency with some forms of primary immunodeficiency disease had led to new approaches to therapy, such as enzyme replacement. In ADA deficiency, bone marrow transplantation remains the primary method of ch...
journal_title：Clinical biochemistry
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journal_title：Clinical biochemistry
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journal_title：Clinical biochemistry
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journal_title：Clinical biochemistry
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pub_type： 杂志文章
doi：10.1016/s0009-9120(89)80094-3
更新日期：1989-12-01 00:00:00
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更新日期：2016-01-01 00:00:00
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更新日期：2021-01-01 00:00:00
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更新日期：1988-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.clinbiochem.2013.07.022
更新日期：2013-12-01 00:00:00
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journal_title：Clinical biochemistry
pub_type： 杂志文章,meta分析,评审
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更新日期：2013-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-03-01 00:00:00
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journal_title：Clinical biochemistry
pub_type： 杂志文章
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journal_title：Clinical biochemistry
pub_type： 杂志文章
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更新日期：2016-05-01 00:00:00
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journal_title：Clinical biochemistry
pub_type： 杂志文章
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更新日期：2001-07-01 00:00:00
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更新日期：2009-07-01 00:00:00
