听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献
  • MicroRNA-204-GSDMD interaction regulates pyroptosis of fibroblast-like synoviocytes in ankylosing spondylitis.

    abstract:OBJECTIVE:Ankylosing spondylitis (AS) is a disease characterized by inflammation of the sacroiliac joint and the attachment point of the spine. This study aimed to investigate the effect of microRNA (miR)-204-targeted GSDMD on fibroblast-like synoviocytes (FLSs) in AS. METHODS:miR-204, GSDMD, pyrolysis-related genes (...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107227

    authors: Gu G,Huo Y,Xu G,Li L,Yu J,Sheng L,Yin Z

    更新日期:2021-02-01 00:00:00

  • Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway.

    abstract::Acute lung injury (ALI) is a common acute respiratory disease treated in the clinic. Intestinal microflora disorder affect lung diseases through the gut-lung axis. In this study, we explored the regulatory mechanism of the gut flora in the host defense against lipopolysaccharide (LPS)-induced ALI through the TLR4/NF-k...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107272

    authors: Tang J,Xu L,Zeng Y,Gong F

    更新日期:2021-02-01 00:00:00

  • Cladribine inhibits secretion of pro-inflammatory cytokines and phagocytosis in human monocyte-derived M1 macrophages in-vitro.

    abstract::Cladribine (Cd) is a purine nucleoside analogue which in an oral formulation is approved for treatment of patients with multiple sclerosis (MS). It is known to mediate the effect through a short-term selective reduction of lymphocytes with minimal effect on the innate immune system. However, a few studies have emerged...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107270

    authors: Mathiesen CBK,Rudjord-Levann AM,Gad M,Larsen J,Sellebjerg F,Pedersen AE

    更新日期:2021-02-01 00:00:00

  • Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax.

    abstract::Apoptotic pathways play an important role in Mycobacterium tuberculosis-infected macrophages. Sirt1 is a member of the deacetylase family that is known to promote apoptosis resistance in many mammalian cells. However, the apoptotic role of Sirt1 in the process of M. tuberculosis infection remains unclear. With the hel...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107283

    authors: Yang H,Chen J,Chen Y,Jiang Y,Ge B,Hong L

    更新日期:2021-02-01 00:00:00

  • A review on the effect of COVID-19 in type 2 asthma and its management.

    abstract:BACKGROUND:COVID-19 is considered the most critical health pandemic of 21st century. Due to extremely high transmission rate, people are more susceptible to viral infection. COVID-19 patients having chronic type-2 asthma prevails a major risk as it may aggravate the disease and morbidities. OBJECTIVE:The present revie...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2020.107309

    authors: Ghosh S,Das S,Mondal R,Abdullah S,Sultana S,Singh S,Sehgal A,Behl T

    更新日期:2021-02-01 00:00:00

  • Association of platelet-to-lymphocyte ratio with kidney clinicopathologic features and renal outcomes in patients with diabetic kidney disease.

    abstract:BACKGROUND:Growing evidence points to the pivotal role of inflammation in the pathogenesis of diabetic kidney disease (DKD). However, as an inflammation-based prognostic score, the significance of platelet-to-lymphocyte ratio (PLR) in biopsy-proven DKD remains uncertain. Therefore, the current study aimed to evaluate t...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2021.107413

    authors: Duan S,Sun L,Zhang C,Wu L,Nie G,Huang Z,Xing C,Zhang B,Yuan Y

    更新日期:2021-01-29 00:00:00

  • 6-Gingerol attenuates ventilator-induced lung injury via anti-inflammation and antioxidative stress by modulating the PPARγ/NF-κBsignalling pathway in rats.

    abstract::Although mechanical ventilation (MV) is indispensable to life-support therapy in critically ill patients, it may promote or aggravatelunginjury known asventilator-inducedlunginjury(VILI). 6-Gingerol is the principal ingredient of ginger with potential anti-inflammatory and antioxidant properties in various diseases. N...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2021.107367

    authors: Hong W,Zhi FX,Kun TH,Hua FJ,Huan Ling L,Fang F,Wen C,Jie W,Yang LC

    更新日期:2021-01-15 00:00:00

  • Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury.

    abstract::Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially fatal disease that is unpredictable and independent of the dose of the drug. Increasing evidence suggests that the majority of IDILI cases are immune-mediated, and the aberrant activation of inflammasome plays a vital role in progression. Psoral...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107352

    authors: Wang Y,Xu G,Wang Z,Li R,Zhan X,Liu H,Qin Q,Li W,Wang X,Zhang M,Tang J,Bai Z,Xiao X

    更新日期:2021-01-07 00:00:00

  • Epigallocatechin-3-gallate reduces liver and immune system damage in Acinetobacter baumannii-loaded mice with restraint stress.

    abstract:AIM:Due to the significant increase in the antimicrobial resistance of Acinetobacter baumannii (A. baumannii), new drugs to block the progression of infection are strongly needed. Epigallocatechin-3-gallate (EGCG), a major component of green tea, has exhibited potential activity against A. baumannii in vitro. The aim o...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107346

    authors: Yan Q,Hao S,Shi F,Zou Y,Song X,Li L,Li Y,Guo H,He R,Zhao L,Ye G,Tang H

    更新日期:2021-01-04 00:00:00

  • Oncostatin M: A mysterious cytokine in cancers.

    abstract::Oncostatin M (OSM), as a member of the Interleukin-6 family cytokines, plays a significant role in inflammation, autoimmunity, and cancers. It is mainly secreted by T lymphocytes, neutrophils, and macrophages and was initially introduced as anti-cancer agent. However, in some cases, it promotes cancer progression. Ove...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2020.107158

    authors: Masjedi A,Hajizadeh F,Beigi Dargani F,Beyzai B,Aksoun M,Hojjat-Farsangi M,Zekiy A,Jadidi-Niaragh F

    更新日期:2021-01-01 00:00:00

  • Identification and verification of an immune-related lncRNA signature for predicting the prognosis of patients with bladder cancer.

    abstract:BACKGROUND:Recent studies have revealed the significant roles of immune-related long noncoding RNAs (lncRNAs) in cancer development and progression. The identification of biomarkers that contribute to early detection and risk stratification provides significant benefits for bladder cancer (BC) patients. The current stu...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107146

    authors: Wang J,Shen C,Dong D,Zhong X,Wang Y,Yang X

    更新日期:2021-01-01 00:00:00

  • Sunitinib malate inhibits intestinal tumor development in male ApcMin/+ mice by down-regulating inflammation-related factors with suppressing β-cateinin/c-Myc pathway and re-balancing Bcl-6 and Caspase-3.

    abstract::Sunitinib is a tyrosine kinase inhibitor for many tumors. Inflammation is one of the most important factors in the development of intestinal tumors. Many inflammation-related factors are regulated by tyrosine kinase receptors. It is reasonable to hypothesize that sunitinib can regulate the development of intestinal tu...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107128

    authors: Chen L,Xu P,Xiao Q,Chen L,Li S,Jian JM,Zhong YB

    更新日期:2021-01-01 00:00:00

  • Imperatorin reduces the inflammatory response of atherosclerosis by regulating MAPKs signaling pathway in vivo and in vitro.

    abstract::Inflammation plays an important role in the process of atherosclerosis (AS). Inhibition of inflammation is an effective way to prevent AS. Imperatorin (IMP) is a kind of furan coumarin with various activities. In this study, the anti-inflammatory effect of IMP was explored in oxidized low-density lipoprotein (ox-LDL)-...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107170

    authors: Li W,Yu J,Xiao X,Zang L,Yang Y,Yu J,Huang Q,Niu X,Li W

    更新日期:2021-01-01 00:00:00

  • Anti-allergic effects of vitamin E in allergic diseases: An updated review.

    abstract::Allergic diseases are caused by the immune system's response to innocent antigens called allergens. Recent decades have seen a significant increase in the prevalence of allergic diseases worldwide, which has imposed various socio-economic effects in different countries. Various factors, including genetic factors, indu...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2020.107196

    authors: Shams MH,Jafari R,Eskandari N,Masjedi M,Kheirandish F,Ganjalikhani Hakemi M,Ghasemi R,Varzi AM,Sohrabi SM,Baharvand PA,Safari M

    更新日期:2021-01-01 00:00:00

  • Salvinorin A protects against methicillin resistant staphylococcus aureus-induced acute lung injury via Nrf2 pathway.

    abstract::Salvinorin A (SA), a neoclerodane diterpene, is isolated from the dried leaves ofSalvia divinorum. SA has traditionally been used treatments for chronic pain diseases. Recent research has demonstrated that SA possesses the anti-inflammatory property. The present study aim to explore the effects and potentialmechanisms...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107221

    authors: Zeng S,Chen D,Liu G,Wu YX,Gao ZQ,Su Y,Yuan JN,Liu L,Shan JC,Pang QF,Zhu T

    更新日期:2021-01-01 00:00:00

  • Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: Potential mechanisms, targets, therapeutic drugs and biomarkers.

    abstract::Hemorrhagic transformation (HT) is a common and serious complication following ischemic stroke, especially after tissue plasminogen activator (t-PA) thrombolysis, which is associated with increased mortality and disability. Due to the unknown mechanisms and targets of HT, there are no effective therapeutic drugs to de...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2020.107216

    authors: Ma G,Pan Z,Kong L,Du G

    更新日期:2021-01-01 00:00:00

  • Syringin exerts neuroprotective effects in a rat model of cerebral ischemia through the FOXO3a/NF-κB pathway.

    abstract::Inflammation plays an important role in the pathogenesis of cerebral ischemia. Syringin (SYR) is an active substance isolated from Acanthopanax senticosus plants, and possesses anti-inflammatory and neuroprotective properties. However, its effects on cerebral ischemic injury, as well as the underlying molecular events...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107268

    authors: Tan J,Luo J,Meng C,Jiang N,Cao J,Zhao J

    更新日期:2021-01-01 00:00:00

  • Regulation of gut microbiota substantially contributes to the induction of intestinal Treg cells and consequent anti-arthritis effect of madecassoside.

    abstract::Previously, we reported that oral administration of madecassoside, the main active triterpene in Centella asiatica L., exerted anti-arthritis effect by inducing the generation of regulatory T (Treg) cells in small intestine. This study investigates the action site and mechanism of madecassoside to induce Treg cells. I...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107047

    authors: Qiao S,Lian X,Yue M,Zhang Q,Wei Z,Chen L,Xia Y,Dai Y

    更新日期:2020-12-01 00:00:00

  • Upregulation of JHDM1D-AS1 alleviates neuroinflammation and neuronal injury via targeting miR-101-3p-DUSP1 in spinal cord after brachial plexus injury.

    abstract:BACKGROUND:Neuroinflammation in the spinal cord following acute brachial plexus injury (BPI) remains a vital cause that leads to motor dysfunction and neuropathic pain. In this study, we aim to explore the role of long non-coding RNA JHDM1D antisense 1 (JHDM1D-AS1) in mediating BPI-induced neuroinflammation and neurona...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106962

    authors: Liu LP,Zhang J,Pu B,Li WQ,Wang YS

    更新日期:2020-12-01 00:00:00

  • Discovery of novel immunopharmacological ligands targeting the IL-17 inflammatory pathway.

    abstract::Interleukin 17 (IL-17) is a proinflammatory cytokine that acts as an immune checkpoint for several autoimmune diseases. Therapeutic neutralizing antibodies that target this cytokine have demonstrated clinical efficacy in psoriasis. However, biologics have limitations such as their high cost and their lack of oral bioa...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107026

    authors: Álvarez-Coiradas E,Munteanu CR,Díaz-Sáez L,Pazos A,Huber KVM,Loza MI,Domínguez E

    更新日期:2020-12-01 00:00:00

  • Sodium houttuyfonate enhances the intestinal barrier and attenuates inflammation induced by Salmonella typhimurium through the NF-κB pathway in mice.

    abstract::Salmonella typhimurium (ST), as an aggressive bacterium, mainly causes intestinal inflammation and diarrhea. Sodium houttuyfonate (SH) is a derivative of houttuynin in the active oil of Houttuynia cordata, which is stable in nature and has anti-inflammatory activity. In this study, we used BALB/c mice infected with ST...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107058

    authors: Zhang L,Lv H,Li Y,Dong N,Bi C,Shan A,Wu Z,Shi B

    更新日期:2020-12-01 00:00:00

  • Identification and verification immune-related regulatory network in acne.

    abstract::Acne is a common inflammatory skin disease with the dysregulation of innate and adaptive immunity. However, the underlying mechanism of acne has not been completely elucidated. In this study, we identified gene signatures and the immune-related regulatory network in acne using integrated bioinformatics methods. Here, ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107083

    authors: Xin Y,Zhang S,Deng Z,Zeng D,Li J,Zhang Y

    更新日期:2020-12-01 00:00:00

  • LXA4 protects against hypoxic-ischemic damage in neonatal rats by reducing the inflammatory response via the IκB/NF-κB pathway.

    abstract::Hypoxia and the resultant decreases in cerebral blood flow in the perinatal period can lead to neonatal hypoxic-ischemic (HI) brain injury, which can, in turn, cause severe disability or even death. However, the efficacy of current treatment strategies remains limited. Several studies have demonstrated that lipoxin A4...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107095

    authors: Zhu JJ,Yu BY,Fu CC,He MZ,Zhu JH,Chen BW,Zheng YH,Chen SQ,Fu XQ,Li PJ,Lin ZL

    更新日期:2020-12-01 00:00:00

  • GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.

    abstract::Chronic cold stress has long-term dramatic effects on the animal immune and neuroendocrine systems. As one of the important regions of the brain, the hippocampus is the main region involved in response to stressors. Nevertheless, the impact to the hippocampus following cold exposure and the underlying mechanism involv...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106908

    authors: Lang L,Xu B,Yuan J,Li S,Lian S,Chen Y,Guo J,Yang H

    更新日期:2020-12-01 00:00:00

  • Analysis of immune subtypes based on immunogenomic profiling identifies prognostic signature for cutaneous melanoma.

    abstract::Skin cutaneous melanoma (SKCM) is the most invasive form of skin cancer with poor prognosis. Growing evidence has demonstrated that tumor immune microenvironment plays a key contributing role in tumorigenesis and predicting clinical outcomes. The aim of this study was to recognize immune classification and a reliable ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107162

    authors: Hu B,Wei Q,Zhou C,Ju M,Wang L,Chen L,Li Z,Wei M,He M,Zhao L

    更新日期:2020-12-01 00:00:00

  • A prognostic signature based on immune-related genes for cervical squamous cell carcinoma and endocervical adenocarcinoma.

    abstract::Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) is the fourth commonest female malignancy worldwide. CESC progresses in immune-microenvironment mainly composed of infiltrating immune and stromal cells. Here, we performed an integrated analysis incorporating the expression profiles from the Canc...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106884

    authors: Liu J,Wu Z,Wang Y,Nie S,Sun R,Yang J,Cheng W

    更新日期:2020-11-01 00:00:00

  • Neutrophil extracellular traps promote corneal neovascularization-induced by alkali burn.

    abstract:OBJECTIVES:To investigate the effects of neutrophil extracellular traps (NETs) on angiogenesis in vitro and in vivo and the regulatory role of mammalian target of rapamycin (mTOR) activity in it. METHODS:The regulatory role of mTOR in NETs formation was explored. In vitro, human neutrophils were pretreated with rapamy...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106902

    authors: Yuan K,Zheng J,Huang X,Zhang Y,Han Y,Hu R,Jin X

    更新日期:2020-11-01 00:00:00

  • Identification of integrative molecular and clinical profiles of Fibrinogen-like protein 2 in gliomas using 1323 samples.

    abstract:BACKGROUND:Fibrinogen-like protein 2 (FGL2), a member of the fibrinogen superfamily, has been described to augment immunosuppression in gliomas. However, the precise clinical molecular features and the prognostic relevance of FGL2 in gliomas remain unclear. Therefore, a comprehensive analysis of the role of FGL2 in gli...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106894

    authors: Song Z,Wang Y,Du Y,Zhang Z,Yuan Y

    更新日期:2020-11-01 00:00:00

  • Overview of the current promising approaches for the development of an effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine.

    abstract::Coronavirus disease 2019 (COVID-19) is a pandemic infectious disease caused by the novel coronavirus called SARS-CoV-2. There is a gap in our understanding regarding the immunopathogenesis of COVID-19. However, many clinical trials are underway across the world for screening effective drugs against COVID-19. Neverthel...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2020.106928

    authors: Mirzaei R,Mohammadzadeh R,Mahdavi F,Badrzadeh F,Kazemi S,Ebrahimi M,Soltani F,Kazemi S,Jeda AS,Darvishmotevalli M,Yousefimashouf R,Keyvani H,Karampoor S

    更新日期:2020-11-01 00:00:00

  • Mechanism of miRNA-based Aconitum leucostomum Worosch. Monomer inhibition of bone marrow-derived dendritic cell maturation.

    abstract::Delvestidine (DLTD) is a monomeric compound isolated from Aconitum leucostomum Worosch, a widely used medicine for local treatment of rheumatoid arthritis (RA). Studies have shown that Aconitum leucostomum Worosch. can inhibit maturation of bone marrow-derived dendritic cells (BMDCs). Further, microRNAs (miRNAs) have ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106791

    authors: Wang YY,Liu HZ,Cao M,Wang XL,Cong S,Sun J,Jia BT,Ta-Bu-Shi NE,Bian YH,Luo L

    更新日期:2020-11-01 00:00:00

  • Increased Galectin-9 expression, a prognostic biomarker of aGVHD, regulates the immune response through the Galectin-9 induced MDSC pathway after allogeneic hematopoietic stem cell transplantation.

    abstract::Galectin-9 (Gal-9) is a β-galactoside-binding soluble lectin family member that exerts its primary biological functions via specific glycoconjugate interactions. Gal-9 expression is closely related to tumor occurrence, development, metastasis and prognosis. In transplant immunology, a high level of Gal-9 expression ha...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106929

    authors: Yin J,Li L,Wang C,Zhang Y

    更新日期:2020-11-01 00:00:00

  • Immunomodulatory-based therapy as a potential promising treatment strategy against severe COVID-19 patients: A systematic review.

    abstract::The global panic of the novel coronavirus disease 2019 (COVID-19) triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent requirement for effective therapy. COVID-19 infection, especially in severely ill patients, is likely to be associated with immune dysregulation, promptin...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106942

    authors: Razmi M,Hashemi F,Gheytanchi E,Dehghan Manshadi M,Ghods R,Madjd Z

    更新日期:2020-11-01 00:00:00

  • The therapeutic potential of resveratrol in a mouse model of melanoma lung metastasis.

    abstract::Resveratrol is an anticancer phytochemical polyphenol isolated from a natural origin, without any significant side effects. Resveratrol was investigated in immunocompetent mice with regards to its possible effect on lung cancer metastasis. Cytotoxicity was assessed in three melanoma cell lines (B16F10, B6, and A375) b...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106905

    authors: Davoodvandi A,Darvish M,Borran S,Nejati M,Mazaheri S,Reza Tamtaji O,Hamblin MR,Masoudian N,Mirzaei H

    更新日期:2020-11-01 00:00:00

  • Long-term inhibition of dipeptidyl-peptidase 4 reduces islet infiltration and downregulates IL-1β and IL-12 in NOD mice.

    abstract::Dipeptidyl-peptidase 4 (DPP-4) inhibitor (sitagliptin) is a novel anti-hyperglycemia drug in the treatment of type 2 diabetes. However, its potential in type 1 diabetes is still unclear. Recent studies show that increased infection, especially respiratory tract infection, is significantly associated with DPP-4 inhibit...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106945

    authors: He X,Li W,Xie Y,Zhao Y

    更新日期:2020-11-01 00:00:00

  • Exosomes released from decidual macrophages deliver miR-153-3p, which inhibits trophoblastic biological behavior in unexplained recurrent spontaneous abortion.

    abstract:BACKGROUND:Spontaneous abortion is a common disease in human pregnancy. Increasing evidence suggests that proper function of trophoblasts and immune balance of the maternal-fetal interface are crucial for successful pregnancy. Macrophages are involved in the maternal-fetal immune microenvironment. However, mechanisms a...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106981

    authors: Ying X,Jin X,Zhu Y,Liang M,Chang X,Zheng L

    更新日期:2020-11-01 00:00:00

  • Lower levels of vitamin D are associated with SARS-CoV-2 infection and mortality in the Indian population: An observational study.

    abstract:BACKGROUND:The role of vitamin D in the susceptibility and severity of various viral diseases has been well documented. Recently, some reports highlighted the possible importance of vitamin D in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although India receives adequate sunlight throughout the year, ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.107001

    authors: Padhi S,Suvankar S,Panda VK,Pati A,Panda AK

    更新日期:2020-11-01 00:00:00

  • IL-6 promotes collagen-induced arthritis by activating the NLRP3 inflammasome through the cathepsin B/S100A9-mediated pathway.

    abstract::Rheumatoid arthritis (RA) is an inflammatory disease with symmetric polyarthritis. IL-6 and NLRP3 inflammasome in macrophages contribute to the pathogenesis of RA. This study aimed to investigate the relationship between IL-6 and the NLRP3 inflammasome in RA. Here, we found that IL-6 inhibition reduced NLRP3 inflammas...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106985

    authors: Wang H,Wang Z,Wang L,Sun L,Liu W,Li Q,Wang J

    更新日期:2020-11-01 00:00:00

  • A signature of 29 immune-related genes pairs to predict prognosis in patients with neuroblastoma.

    abstract:BACKGROUND:Neuroblastoma (NB) is one of the most common childhood tumors that is associated with a poor prognosis. Recently, immunotherapy has been recognized as an effective strategy in the treatment of NB patients. In this study, an immune-related gene pair (IRGP) signature was established for predicting the prognosi...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106994

    authors: Song J,Zhao Q,Xu Y,Zhu L

    更新日期:2020-11-01 00:00:00

  • A novel chrysin thiazole derivative polarizes macrophages to an M1 phenotype via targeting TLR4.

    abstract::Tumor-associated macrophages (TAMs) are an important cause of tumorigenesis and tumor development. M2 macrophages can promote tumor growth while M1 macrophages kill tumor cells, therefore, polarizing macrophages to achieve a functional M1 phenotype could effectively play its anti-tumor role. In the current study, we s...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106986

    authors: Feng X,Yu W,Cao L,Meng F,Cong M

    更新日期:2020-11-01 00:00:00

  • Irbesartan may relieve renal injury by suppressing Th22 cells chemotaxis and infiltration in Ang II-induced hypertension.

    abstract::Angiotensin II (Ang II) as an important pathogenic factor, has been implicated in the pathogenesis of hypertension and associated renal injury, and inhibition of Ang II can reduce renal inflammation and exert renal protective effects. In the present study, we determine the infiltration of Th22 cells in kidney and seru...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106789

    authors: Zhong Y,Tang R,Lu Y,Wang W,Xiao C,Meng T,Ao X,Li X,Peng L,Kwadwo Nuro-Gyina P,Zhou Q

    更新日期:2020-10-01 00:00:00

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