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Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax.

Abstract：

:Apoptotic pathways play an important role in Mycobacterium tuberculosis-infected macrophages. Sirt1 is a member of the deacetylase family that is known to promote apoptosis resistance in many mammalian cells. However, the apoptotic role of Sirt1 in the process of M. tuberculosis infection remains unclear. With the help of mouse macrophage samples, 129/Sv background mice, and PBMCs-derived macrophages from healthy controls and patients with tuberculosis, we have shown that M. tuberculosis infection reduced Sirt1 mRNA and protein expression, however, increased Bax mRNA and protein expression. Further, we found that resveratrol, a Sirt1 activator, inhibited M. tuberculosis-induced Bax expression. Thus, it seems that Sirt1 acts as a novel regulator of apoptosis signaling in M. tuberculosis infection via its effects on Bax. Sirt1 activation may therefore be a new candidate for the prevention and treatment of tuberculosis.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Yang H,Chen J,Chen Y,Jiang Y,Ge B,Hong L

doi

10.1016/j.intimp.2020.107283

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

107283

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(20)33750-4

journal_volume

91

pub_type

杂志文章

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