γδ T cells in infection and autoimmunity.

Abstract:

:Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers and require different cytokine signaling to maintain the homeostasis. In addition, as the major innate IL-17 producers, γδ T cells are increasingly appreciated for their involvement in various acute infections and injuries. This review will summarize the characteristics of IFN-γ(+) (γδ T-IFN-γ) and IL-17(+) γδ T cells (γδT17) and discuss their distinct pathogenic functions in different disease models.

journal_name

Int Immunopharmacol

authors

Hou L,Wang T,Sun J

doi

10.1016/j.intimp.2015.03.038

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

887-91

issue

2

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(15)00140-X

journal_volume

28

pub_type

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