Abstract:
:Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers and require different cytokine signaling to maintain the homeostasis. In addition, as the major innate IL-17 producers, γδ T cells are increasingly appreciated for their involvement in various acute infections and injuries. This review will summarize the characteristics of IFN-γ(+) (γδ T-IFN-γ) and IL-17(+) γδ T cells (γδT17) and discuss their distinct pathogenic functions in different disease models.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Hou L,Wang T,Sun Jdoi
10.1016/j.intimp.2015.03.038subject
Has Abstractpub_date
2015-10-01 00:00:00pages
887-91issue
2eissn
1567-5769issn
1878-1705pii
S1567-5769(15)00140-Xjournal_volume
28pub_type
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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