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Effects of astilbic acid on airway hyperresponsiveness and inflammation in a mouse model of allergic asthma.

Abstract：

:Bronchial asthma is characterized by chronic lung inflammation, airway hyperresponsiveness (AHR), and airway remodeling. Astilbic acid, extracted from the medicinal herb Astilbe chinensis, is used as a headache remedy in traditional medicine and has anti-pyretic and analgesic effects. However, the effect of astilbic acid on asthma remains to be established. In the present study, we therefore examined the effect of astilbic acid in a mouse model in which asthma was established by sensitization and challenge with ovalbumin (OVA). Astilbic acid inhibited OVA-induced AHR to inhaled methacholine and significantly suppressed the levels of T-helper 2-type cytokines (including IL [interleukin]-4, IL-5, and IL-13) and inflammatory cells (including eosinophils) in bronchoalveolar lavage (BAL) fluid. Histochemical analysis revealed reduced goblet cell hyperplasia and mucus production, as well as attenuated eosinophil-rich leukocyte infiltration, in the astilbic acid-treated group, compared with OVA-challenged mice. Moreover, the compound significantly inhibited synthesis of IL-4-, IL-5-, IL-13-, IL-17-, and eotaxin-encoding mRNA following asthma induction in lung tissue, in addition to suppressing the immunoglobulin E (IgE) response to asthma in both BAL fluid and serum. Our results indicate that astilbic acid has great potential as a therapeutic candidate for the treatment of asthma.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Yuk JE,Lee MY,Kwon OK,Cai XF,Jang HY,Oh SR,Lee HK,Ahn KS

doi

10.1016/j.intimp.2010.12.002

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

266-73

issue

2

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(10)00405-4

journal_volume

11

pub_type

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