Abstract：
:The aim of this study was to investigate whether fever and antipyretic drugs had an adverse effect on human polymorphonuclear leukocyte (PMN) functions (phagocytic and intracellular killing activity). Twenty febrile children with an axillary temperature of 39-40 degrees C and 20 healthy children without fever were included. Polymorphonuclear leukocytes were isolated. The effects of in vitro addition of antipyretic drugs (acetaminophen, metamizole sodium, nimesulid and ibuprofen) on PMN functions were tested. Phagocytic activity was assayed by the ingestion of yeast cells by PMNs and intracellular killing activity by the ingestion of yeast cells (stained blue) killed by PMNs. PMNs derived from febrile children exhibited better phagocytic activity when ibuprofen was added. In contrast, phagocytic activity was enhanced when acetaminophen, metamizole sodium or nimesulid was added in children without fever. Intracellular killing activity was enhanced when ibuprofen or metamizole sodium was added in children without fever. We conclude the antipyretic drugs at safely achievable concentrations do not suppress PMN function in vitro.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Gürer US,Palanduz A,Gürbüz B,Yildirmak Y,Cevikbaş A,Kayaalp Ndoi
10.1016/s1567-5769(02)00136-4keywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
1599-602issue
11eissn
1567-5769issn
1878-1705pii
S1567-5769(02)00136-4journal_volume
2pub_type
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更新日期：2015-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-01-01 00:00:00
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doi：10.1016/j.intimp.2017.04.002
更新日期：2017-06-01 00:00:00
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更新日期：2001-04-01 00:00:00
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journal_title：International immunopharmacology
pub_type： 杂志文章,评审
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更新日期：2020-01-01 00:00:00
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更新日期：2002-02-01 00:00:00
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