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The novel non-mitogenic anti-CD3 antibody, mini-yCD3, delivers a partial TCR signal.

Abstract：

:Previous studies indicated that a partial T-cell receptor signal delivered by non-mitogenic anti-CD3 antibodies is critical for dampening the activated T-cell response. The mini-yCD3 is a novel non-mitogenic anti-CD3 antibody based on a murine anti-human CD3 antibody yCD3. However, the mechanism by which mini-yCD3 suppresses immune responses mediated by activated T-cells remains unknown. To elucidate its mechanism, we examined the effects of the mini-yCD3 on early signaling events in T-cells. Similar to the mitogenic anti-CD3 mAb, mini-yCD3 triggered changes in the T-cell receptor (TCR). However, unlike the mitogenic anti-CD3 stimulation, mini-yCD3 was ineffective at inducing the highly phosphorylated zeta chain and tyrosine phosphorylation of the associated tyrosine kinase ZAP-70. This proximal signaling deficiency failed to mobilize detectable Ca(2+) and translocate NF-AT into the nucleus. Additionally, the non-mitogenic anti-CD3 appeared insufficient for the redistribution of TCRs into an aggregated cap, which correlated with T-cell activation.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Lv M,Qiao C,Lin Z,Yu M,Hou C,Sun Y,Li Y,Feng J,Shen B

doi

10.1016/j.intimp.2009.10.016

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

200-6

issue

2

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(09)00349-X

journal_volume

10

pub_type

杂志文章

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