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CXCR3-deficient natural killer cells fail to migrate to B16F10 melanoma cells.

Abstract：

:Natural killer (NK) cells eliminate cancer cells in a contact-dependent manner. However, how NK cells find cancer cells remain unclear. Here, using time-lapse imaging, we investigated how individual NK cells migrate toward cancer cells. Although naïve B16F10 cancer cells produce low levels of chemokines, IFN-γ-treated B16F10 cells secreted high levels of CXCL10, low levels of CCL5, but did not secrete CCL2, CCL7, or CXCL12. Wild-type NK cells migrated well toward cancer cells and killed them, whereas NK cells deficient in CXCR3 did not. CXCR3-deficient NK cells also showed slower migration speed than did wild-type NK cells. Taken together, our data show that NK cells find cancer cells, at least in part, by sensing CXCL10 produced by cancer cells and suggest that a strategy to increase CXCL10 secretion by cancer cells may improve the efficacy of NK cell-based immunotherapy.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Kim J,Kim JS,Lee HK,Kim HS,Park EJ,Choi JE,Choi YJ,Shin BR,Kim EY,Hong JT,Kim Y,Han SB

doi

10.1016/j.intimp.2018.07.026

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

66-73

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(18)30355-2

journal_volume

63

pub_type

杂志文章

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