miR-181a regulates Th17 cells distribution via up-regulated BCL-2 in primary biliary cholangitis.


BACKGROUND:Primary biliary cholangitis (PBC) is an autoimmune liver disease characterised by destruction of small intrahepatic bile ducts. Recent studies suggest that miRNAs play a critical role in the pathogenesis of liver diseases. However the role served by miRNAs in the pathogenesis of PBC is still not clear. METHODS:The differentially expressed genes and miRNAs were identified by bioinformatics analysis. Gene ontology and KEGG pathway analyses were conducted to explore the function of the differentially expressed genes. miRNA target genes were predicted using miRecords. The differentially expressed genes and miRNAs were validated by qRT-PCR in PBC patients along with healthy controls and chronic hepatitis B patients as control. Flow cytometric analysis was conducted to identify the Th17 and Treg cells frequency. RESULTS:15 differentially expressed miRNAs and 1897 mRNAs were identified from the profile. miR-181a was validated as the differentially expressed miRNA. BCL-2 and CDKN1B were predicted as the target gene of miR-181a and validated differentially expressed in PBC patients. However, only BCL-2 was negative correlated with miR-181a. The Th17 cells frequency was increased in PBC patients while the Treg cells frequency was decreased. Moreover, the expression of BCL-2 was positive correlated with Th17 cells frequency. CONCLUSION:Down-regulated miR-181a in CD4+ T cells may decrease apoptosis of Th17 cells via up-regulated BCL-2 in the pathogenesis of PBC.


Int Immunopharmacol


Song Y,Yang H,Jiang K,Wang BM,Lin R




Has Abstract


2018-11-01 00:00:00












  • Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia.

    abstract::Upon activation, brain macrophages, the microglia, release proinflammatory mediators that play important roles in eliciting neuroinflammatory responses associated with neurodegenerative diseases. As resveratrol, an antioxidant component of grape, has been reported to exert anti-inflammatory activities on macrophages, ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Bi XL,Yang JY,Dong YX,Wang JM,Cui YH,Ikeshima T,Zhao YQ,Wu CF

    更新日期:2005-01-01 00:00:00

  • The novel non-mitogenic anti-CD3 antibody, mini-yCD3, delivers a partial TCR signal.

    abstract::Previous studies indicated that a partial T-cell receptor signal delivered by non-mitogenic anti-CD3 antibodies is critical for dampening the activated T-cell response. The mini-yCD3 is a novel non-mitogenic anti-CD3 antibody based on a murine anti-human CD3 antibody yCD3. However, the mechanism by which mini-yCD3 sup...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Lv M,Qiao C,Lin Z,Yu M,Hou C,Sun Y,Li Y,Feng J,Shen B

    更新日期:2010-02-01 00:00:00

  • Intramolecular signal transduction by the bradykinin B2 receptor.

    abstract::To study the intramolecular signal transduction, we performed single point and cassette mutations in transmembranal and intracellular regions of the bradykinin B2 receptor. We studied the influence of the two intramembranal Cys residues at positions 304 and 348, the role of Arg at position 177 in the highly conserved ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Mueller S,Liebmann C,Reissmann S

    更新日期:2002-12-01 00:00:00

  • Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes.

    abstract:BACKGROUND:Chondrocytes are one of the main cell types involved in rheumatoid inflammation, releasing mediators which add to cartilage destruction, bone damage and consequently disability. Current evidence suggests that serotonin 5-HT(3) receptor antagonists (5-HT(3)RA) show anti-inflammatory and antioxidant properties...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Stratz C,Anakwue J,Bhatia H,Pitz S,Fiebich BL

    更新日期:2014-09-01 00:00:00

  • Thalidomide treatment modulates macrophage pro-inflammatory function and cytokine levels in Klebsiella pneumoniae B5055 induced pneumonia in BALB/c mice.

    abstract::Lung innate immune response plays an important role in the clearance of pathogens from lungs, however, profound activation of innate immune cells (alveolar macrophages or neutrophils) can lead to development of acute lung inflammation or injury by producing various pro-inflammatory molecules (IL-1, TNF-alpha and H2O2 ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Kumar V,Harjai K,Chhibber S

    更新日期:2010-07-01 00:00:00

  • Macrophage-oriented cytotoxic activity of novel triterpene saponins extracted from roots of Securidaca inappendiculata.

    abstract::It is recognized that macrophages in peripheral tissues often proliferate under pathological conditions such as tumors, inflammation and atherosclerosis. Because the growth state of macrophages is believed to be a factor regulating the pathological process of the diseases, substances that regulate macrophage growth or...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Yui S,Ubukata K,Hodono K,Kitahara M,Mimaki Y,Kuroda M,Sashida Y,Yamazaki M

    更新日期:2001-10-01 00:00:00

  • Isoliquiritigenin ameliorates dextran sulfate sodium-induced colitis through the inhibition of MAPK pathway.

    abstract::Isoliquiritigenin (isoLQ), a chalcone found in licorice, has shown a variety of biological activity including anti-inflammatory and antioxidative effects, and the distribution of isoLQ in gastrointestinal tract was higher than any other tissues. Thus, we evaluated whether or not isoLQ attenuated the dextran sulfate so...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Choi YH,Bae JK,Chae HS,Choi YO,Nhoek P,Choi JS,Chin YW

    更新日期:2016-02-01 00:00:00

  • Immunological evaluation of colonic delivered Hepatitis B surface antigen loaded TLR-4 agonist modified solid fat nanoparticles.

    abstract::Hepatitis B is one of the leading liver diseases and remains a major global health problem. Currently available vaccines provide protection but often results in weaker/minimal mucosal immunity. Thus the present study is devoted to the development and in-vivo exploration of the colonically delivered biomimetic nanopart...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Sahu KK,Pandey RS

    更新日期:2016-10-01 00:00:00

  • Azithromycin ameliorates OVA-induced airway remodeling in Balb/c mice via suppression of epithelial-to-mesenchymal transition.

    abstract::Azithromycin is a potent agent that prevents airway remodeling. In this study, we hypothesized that azithromycin (35 mg/kg orally) alleviated airway remodeling through suppression of epithelial-to-mesenchymal transition (EMT) via downregulation of transforming growth factor-beta 1 (TGF-β1)/receptor for activated C-kin...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Pu Y,Liu Y,Liao S,Miao S,Zhou L,Wan L

    更新日期:2018-05-01 00:00:00

  • Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: Potential mechanisms, targets, therapeutic drugs and biomarkers.

    abstract::Hemorrhagic transformation (HT) is a common and serious complication following ischemic stroke, especially after tissue plasminogen activator (t-PA) thrombolysis, which is associated with increased mortality and disability. Due to the unknown mechanisms and targets of HT, there are no effective therapeutic drugs to de...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Ma G,Pan Z,Kong L,Du G

    更新日期:2021-01-01 00:00:00

  • Induction of MLR-Bf and protection of fetal loss: a current double blind randomized trial of paternal lymphocyte immunization for women with recurrent spontaneous abortion.

    abstract::The present study was conducted to evaluate the efficacy of paternal lymphocyte (PL) immunotherapy and its relation with the development of mixed lymphocyte reaction blocking antibodies (MLR-Bf) and the success of pregnancy outcome in women with recurrent spontaneous abortion (RSA). A total of 124 women with unknown c...

    journal_title:International immunopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pandey MK,Agrawal S

    更新日期:2004-02-01 00:00:00

  • DGAEE, a newly synthesized derivative of glycyrrhetinic acid, potently attenuates mouse septic shock via its main metabolite DGA in an IL-10-dependent manner.

    abstract::Endotoxin can stimulate inflammatory cytokine release from monocytes/macrophages and result in septic shock. Glycyrrhetinic acid (GA), the main bioactive component of licorice, possesses substantial anti-inflammatory activity. Here, we explored effect of 11-deoxy-18α-glycyrrhetinic acid-30-ethyl ester (DGAEE), a newly...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Luo J,Liu M,Wu X,Dou Y,Xia Y,Dai Y,Wei Z

    更新日期:2015-12-01 00:00:00

  • Lectin from Abelmoschus esculentus reduces zymosan-induced temporomandibular joint inflammatory hypernociception in rats via heme oxygenase-1 pathway integrity and tnf-α and il-1β suppression.

    abstract::Temporomandibular joint (TMJ) disorders show inflammatory components, heavily impacting on quality of life. Abelmoschus esculentus is largely cultivated in Northeastern Brazil for medicinal purposes, having it shown anti-inflammatory activity. We evaluated A. esculentus lectin (AEL) efficacy in reducing zymosan-induce...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Freitas RS,do Val DR,Fernandes ME,Gomes FI,de Lacerda JT,SantiGadelha T,de Almeida Gadelha CA,de Paulo Teixeira Pinto V,Cristino-Filho G,Pereira KM,de Castro Brito GA,Bezerra MM,Chaves HV

    更新日期:2016-09-01 00:00:00

  • Adenovirus-mediated transduction with Histone Deacetylase 4 ameliorates disease progression in an osteoarthritis rat model.

    abstract:BACKGROUND:Downregulation of histone deacetylase-4 (HDAC4) contributes to cartilage degeneration in osteoarthritis (OA) because it promotes upregulation of runt-related transcription factor-2 (Runx-2) and osteoarthritis-related genes. The effect of HDAC4 upregulation on cartilage damage in OA remains unknown. METHODS:...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Gu XD,Wei L,Li PC,Che XD,Zhao RP,Han PF,Lu JG,Wei XC

    更新日期:2019-10-01 00:00:00

  • Chlorophyllin suppresses interleukin-1 beta expression in lipopolysaccharide-activated RAW 264.7 cells.

    abstract::Our previous findings demonstrated that chlorophyllin (CHL) inhibits inducible nitric oxide gene expression in macrophages. In the present study, we show that CHL inhibited IL-1beta production and its mRNA expression in a lipopolysaccharide (LPS)-stimulated murine macrophage cell-line, RAW 264.7. The inhibitory effect...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Yun CH,Jeon YJ,Yang Y,Ju HR,Han SH

    更新日期:2006-02-01 00:00:00

  • Natural product derived immune-regulatory agents.

    abstract::We can now declare that the clinical goal of immune intervention as a therapeutic strategy for neoplastic, infectious, autoimmune and inflammatory diseases, has been achieved and in many instances obtained regulatory approval. Although, interest in and optimism for this approach has fluctuated, in the last 20years, im...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审


    authors: Talmadge JE

    更新日期:2016-08-01 00:00:00

  • Dihydroberberine, a hydrogenated derivative of berberine firstly identified in Phellodendri Chinese Cortex, exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways.

    abstract::Dihydroberberine (DHB), a hydrogenated derivative of berberine (BBR), has been firstly identified in Phellodendri Chinese Cortex (PC) by HPLC-ESI-MS/MS. Nowadays most researches on PC focus on its main components like BBR, however, the role of its naturally-occurring derivatives remains poorly defined heretofore. The ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Tan L,Wang Y,Ai G,Luo C,Chen H,Li C,Zeng H,Xie J,Chen J,Su Z

    更新日期:2019-10-01 00:00:00

  • TACI-Ig induces immune balance of Th cells in MLN via BLyS/APRIL-receptors signaling in rats with adjuvant-induced arthritis.

    abstract::The transmembrane activator and calcium modulator and cyclophilin ligand interactor-immunoglobulin (TACI-Ig), a recombinant fusion protein that modulates B and T cells activation by binding and neutralizing B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), has been shown to have a therapeutic...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Qin Q,Chang Y,Wang D,Wu Y,Zhang LL,Wei W

    更新日期:2011-12-01 00:00:00

  • Immune responses modulation by curcumin and allergen encapsulated into PLGA nanoparticles in mice model of rhinitis allergic through sublingual immunotherapy.

    abstract::The purpose of this study was the combination of curcumin and ovalbumin in free form or encapsulated into PLGA NPs (polylactic co-glycolic acid nanoparticles) to enhance their sublingual immunotherapy (SLIT) efficiency in mouse model of rhinitis allergic. PLGA NPs containing curcumin (CUR), ovalbumin (OVA) or both wer...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Shahgordi S,Sankian M,Yazdani Y,Mashayekhi K,Hasan Ayati S,Sadeghi M,Saeidi M,Hashemi M

    更新日期:2020-07-01 00:00:00

  • Aspirin modified dendritic cells are potent inducers of allo-specific regulatory T-cells.

    abstract::Salicylic acid (aspirin) is a widely used pharmacological agent with immunodmodulatory properties. Dendritic cells are key regulators of the immune response, and are capable of inducing hyporesponsiveness and regulatory activity in CD4+ T-cells. We have demonstrated that aspirin-treated dendritic cells are effective a...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Buckland M,Jago C,Fazekesova H,George A,Lechler R,Lombardi G

    更新日期:2006-12-20 00:00:00

  • Establishing a high microbial load maternal-offspring asthma model in adult mice.

    abstract:BACKGROUND:Although it is widely accepted that the "hygiene hypothesis" explains the increased incidence of asthma, the lack of suitable animal models hinders further in-depth studies of the underlying molecular immune mechanisms. Therefore, we aimed to develop a robust mouse asthma model to investigate the role of bac...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Li Y,Tu C,Chen M,Tan C,Zheng X,Wang Z,Liang Y,Wang K,Wu J,Li H,Liu J

    更新日期:2020-06-01 00:00:00

  • Effects of uridine, isomatitol and 4-thiouridine on in vitro cell adhesion and in vivo effects of 4-thiouridine in a lung inflammation model.

    abstract::Since leukocyte adhesion to endothelial cells is crucial for extravasation of leukocytes to sites of inflammation, inhibition of cell-cell adhesion has been suggested as a means to achieve selective modulation of the immune system. We have, using a static in vitro adhesion assay involving adhesion of granulocytes to t...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Uppugunduri S,Gautam C

    更新日期:2004-09-01 00:00:00

  • Baicalein attenuates the neuroinflammation in LPS-activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2/NF-κB expressions and regulation of metabolic abnormality.

    abstract::Baicalein (5,6,7-trihydroxyflavone), isolated from the root of traditional Chinese herb Scutellaria baicalensis Georgi, has anti-inflammatory and anti-oxidative activities. This study explored the protective and modulatory mechanisms of baicalein on neuroinflammation, oxidative stress and metabolic abnormality in lipo...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Yan JJ,Du GH,Qin XM,Gao L

    更新日期:2020-02-01 00:00:00

  • Anti-brain cholinergic auto antibodies from primary Sjögren syndrome sera modify simultaneously cerebral nitric oxide and prostaglandin biosynthesis.

    abstract::The presence of circulating antibodies from primary Sjögren Syndrome (pSS) patients enable to interact with rat cerebral frontal cortex by activating muscarinic acetylcholine receptors (mAChR). ELISA assay for PGE2 generation, nitric oxide synthase (NOS) activity was measured in cerebral frontal cortex slices by produ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Orman B,Sterin-Borda L,De Couto Pita A,Reina S,Borda E

    更新日期:2007-12-05 00:00:00

  • Selective modulation of lymphoproliferation and cytokine production via intracellular signaling targets by α1- and α2-adrenoceptors and estrogen in splenocytes.

    abstract:UNLABELLED:The mechanistic implications of the presence of sympathetic noradrenergic innervation in lymphoid organs in synaptic association with lymphocytes open to the influence of hormonal fluctuations throughout reproductive age in females has not been investigated yet. OBJECTIVES:The aim of the present study is to...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Priyanka HP,ThyagaRajan S

    更新日期:2013-11-01 00:00:00

  • Accumulation of cytosolic dsDNA contributes to fibroblast-like synoviocytes-mediated rheumatoid arthritis synovial inflammation.

    abstract::The accumulation of cytosolic dsDNA plays important roles in the regulation of cellular processes. However, whether cytosolic dsDNA is involved in the pathogenesis of rheumatoid arthritis (RA) is not clear. Therefore, the present study investigated the roles of cytosolic dsDNA in the modulation of inflammatory respons...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Wang J,Li R,Lin H,Qiu Q,Lao M,Zeng S,Wang C,Xu S,Zou Y,Shi M,Liang L,Xu H,Xiao Y

    更新日期:2019-11-01 00:00:00

  • Isolation and purification of immune cells from the liver.

    abstract::Isolating and purifying liver immune cells are crucial for observing the changes in intrahepatic immune responses during the development of liver diseases and exploring the potential immunological mechanisms. Therefore, the aim of this study was to provide an optimal protocol for isolating immune cells with a high yie...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Shi W,Wang Y,Zhang C,Jin H,Zeng Z,Wei L,Tian Y,Zhang D,Sun G

    更新日期:2020-08-01 00:00:00

  • Amaranthus spinosus water extract directly stimulates proliferation of B lymphocytes in vitro.

    abstract::Amaranthus spinosus Linn. (thorny amaranth), a plant that grows in the wild fields of Taiwan, is extensively used in Chinese traditional medicine to treat diabetes. There have been no published studies on the immunological effects of A. spinosus. To determine whether A. spinosus has immuno-modulatory effects and clari...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Lin BF,Chiang BL,Lin JY

    更新日期:2005-04-01 00:00:00

  • Imiquimod-related dermatitis is mainly mediated by mast cell degranulation via Mas-related G-protein coupled receptor B2.

    abstract::While imiquimod (IMQ) has been widely used in dermatology, its side effect manifested as dermatitis couldn't be ignored. However, the underlying mechanism has not been fully understood. Considering the clinical features of IMQ-related dermatitis similar to pseudo-allergic reaction and the presence of large numbers of ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Hao Y,Peng B,Che D,Zheng Y,Kong S,Liu R,Shi J,Han H,Wang J,Cao J,Zhang Y,Gao J,He L,Geng S

    更新日期:2020-04-01 00:00:00

  • Swertiamarin, a natural steroid, prevent bone erosion by modulating RANKL/RANK/OPG signaling.

    abstract::Bone erosion is a central feature of rheumatoid arthritis (RA) that is characterized by the infiltration of the synovial lining by osteoclasts and lymphocytes. In the present study, swertiamarin a major secoiridoid glycoside was evaluated for anti-osteoclastogenic property to prevent bone erosion in Freund's complete ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章


    authors: Hairul-Islam MI,Saravanan S,Thirugnanasambantham K,Chellappandian M,Simon Durai Raj C,Karikalan K,Gabriel Paulraj M,Ignacimuthu S

    更新日期:2017-12-01 00:00:00