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Allyl isothiocyanate regulates caspase-1/receptor interacting protein-2 expression.

Abstract：

:Isothiocyanates can inhibit nuclear factor-kappaB (NF-kappaB) activation. Interleukin (IL)-1β activates the NF-kappaB, which in turn activates proteins involved in inflammation. IL-1β is directly associated with caspase-1 activation. We tested the anti-inflammatory effect of allyl isothiocyanate (AITC) in mast cells. AITC suppressed the intracellular calcium level in the phorbol myristate acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line. AITC decreased PMA plus A23187-induced cystein-aspartic acid protease (caspase)-1 activity. Particularly, AITC decreased PMA plus A23187-induced caspase-1/receptor interacting protein-2 expression as well as the mRNA expression and production of IL-1β. An in-depth research of the cellular targets of the AITC is warranted.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Han NR,Park W,Um JY,Kim HM,Jeong HJ

doi

10.1016/j.intimp.2010.12.021

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

525-8

issue

4

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(11)00005-1

journal_volume

11

pub_type

杂志文章

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