Combined treatment with colchicine and Herba Taraxaci (Tarazacum mongolicum Hand.-Mazz.) attenuates Behcet's disease-like symptoms in mice and influences the expressions of cytokines.

abstract：:Platelets have been proved to exacerbate influenza infection and its complications. Inhibition of platelet activation may be a feasible method for preventing severe infection and secondary acute lung injury (ALI). Isofraxidin (IFD) is a natural coumarin isolated from the plants Sarcandra glabra and Siberian ginseng, a...

journal_title：International immunopharmacology

authors： Jin L,Ying ZH,Yu CH,Zhang HH,Yu WY,Wu XN

更新日期：2020-07-01 00:00:00

abstract：:Macrophages are highly plastic cells. Depending on stimulation, macrophages rapidly polarize to functionally distinct phenotypes that are involved in the pathogenesis of inflammatory bowel disease (IBD). 1,25‑Dihydroxyvitamin D (1,25(OH)2D3) has immunomodulatory activity, and 1,25(OH)2D3 deficiency is correlated with ...

journal_title：International immunopharmacology

authors： Zhu X,Zhu Y,Li C,Yu J,Ren D,Qiu S,Nie Y,Yu X,Xu X,Zhu W

更新日期：2019-02-01 00:00:00

abstract：:Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities. In this study, we tested the in vivo effect of AC-PS on immune function by evalua...

journal_title：International immunopharmacology

authors： Chen YJ,Cheng PC,Lin CN,Liao HF,Chen YY,Chen CC,Lee KM

更新日期：2008-03-01 00:00:00

abstract：:Acute lung injury (ALI), induced by intestinal ischemia reperfusion (II/R) injury, is characterized by pulmonary edema and inflammation. Aquaporin 4 (AQP4), has been pointed out recently involving in edema development. Previous studies have shown that p38 mitogen activated protein kinase (MAPK) activation resulted in ...

journal_title：International immunopharmacology

authors： Xiong LL,Tan Y,Ma HY,Dai P,Qin YX,Yang RA,Xu YY,Deng Z,Zhao W,Xia QJ,Wang TH,Zhang YH

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:COVID-19 is considered the most critical health pandemic of 21st century. Due to extremely high transmission rate, people are more susceptible to viral infection. COVID-19 patients having chronic type-2 asthma prevails a major risk as it may aggravate the disease and morbidities. OBJECTIVE:The present revie...

journal_title：International immunopharmacology

authors： Ghosh S,Das S,Mondal R,Abdullah S,Sultana S,Singh S,Sehgal A,Behl T

更新日期：2021-02-01 00:00:00

abstract：:Understanding of oligodendrocyte precursor cells and their role in the generation of oligodendrocytes in developing and adult rodents has been considered, particularly much less is known about aged-rodent oligodendrocyte precursor cells and their cell lineage. In this present study, we have developed oligodendrocyte c...

journal_title：International immunopharmacology

authors： Kobayashi J,Seiwa C,Sakai T,Gotoh M,Komatsu Y,Yamamoto M,Fukutake M,Matsuno K,Sakurai Y,Kawano Y,Asou H

更新日期：2003-07-01 00:00:00

abstract：:Current evidence indicates that semicarbazide-sensitive amine oxidase (SSAO) substrates possess insulin-mimic effect, which was thought to play an anti-inflammatory role. The purpose of the present study was to determine whether SSAO substrates benzylamine (BZA) and methylamine (MA) attenuate inflammatory response ind...

journal_title：International immunopharmacology

authors： Lin Z,Li H,Luo H,Zhang Y,Luo W

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Lung adenocarcinoma (LUAD) is a crucial pathological type of lung cancer. Immune-infiltration of the tumor microenvironment positively associated with overall survival in LUAD. TTC21A is a gene has not reported in cancer, and the mechanism behind it is still unclear. Our study assesses TTC21A role in LUAD, v...

journal_title：International immunopharmacology

authors： Wang W,Ren S,Wang Z,Zhang C,Huang J

更新日期：2020-01-01 00:00:00

abstract：:Inflammatory factors play an important role in the pathogenesis of diabetic vascular complications. Considerable interest in the therapeutic potential of mesenchymal stem cells (MSCs) has recently arisen. The purposes of this study were to investigate the effects of MSCs on endothelial cells under inflammatory conditi...

journal_title：International immunopharmacology

authors： Shi M,Yuan Y,Liu J,Chen Y,Li L,Liu S,An X,Luo R,Long D,Chen B,Du X,Cheng J,Lu Y

更新日期：2018-08-01 00:00:00

abstract：:Mannan-binding lectin (MBL) constitutes an important part of the innate immune defence by effecting the deposition of complement on microbial surfaces. MBL deficiency is among the most common primary immunodeficiencies and is associated with recurrent infections and symptoms of poor immune complex clearance. Plasma-de...

journal_title：International immunopharmacology

authors： Vorup-Jensen T,Sørensen ES,Jensen UB,Schwaeble W,Kawasaki T,Ma Y,Uemura K,Wakamiya N,Suzuki Y,Jensen TG,Takahashi K,Ezekowitz RA,Thiel S,Jensenius JC

更新日期：2001-04-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) has emerged as a common public health problem that can progress to end-stage liver disease. Although the function of aquaglyceroporin-9 (AQP9) as a glycerol channel has been proven, the mechanism of AQP9 in the development of NAFLD is poorly understood. To investigate the effe...

journal_title：International immunopharmacology

authors： Cai C,Wang C,Ji W,Liu B,Kang Y,Hu Z,Jiang Z

更新日期：2013-03-01 00:00:00

abstract：:Our previous work showed that SEP, a novel glucan isolated from the eggs of sea urchins, Strongylocentrotus nudus, had remarkable anti-tumor activity. To elucidate the mechanism of the anti-tumor activity, the immunomodulatory activity of SEP was investigated. The in vivo experiment results showed that SEP remarkably ...

journal_title：International immunopharmacology

authors： Liu C,Xi T,Lin Q,Xing Y,Ye L,Luo X,Wang F

更新日期：2008-12-20 00:00:00

abstract：:Although numerous studies demonstrate the participation of nitric oxide (NO) in various inflammatory diseases, the precise function of NO in allergic asthma remains unclear. We investigated whether iNOS inhibition could interfere with the kinetics of VLA-4 and Mac-1 expression and adhesion properties of bone marrow an...

journal_title：International immunopharmacology

authors： Pelaquini EH,Guimarães Lde A,Benetti LR,Fernandes LG,Tamashiro WM,Conran N,Ferreira HH

更新日期：2011-02-01 00:00:00

abstract：:Butyrylcholinesterase (BChE) degrades acetylcholine in addition to acetylcholinesterase (AChE) which is involved in embryonic development of limbs. Since BChE is expressed by osteoblast-like cells we asked whether it is functional in adult bone remodeling. We addressed this issue by analyzing BChE gene-deficient mice ...

journal_title：International immunopharmacology

authors： Haupt M,Kauschke V,Sender J,Kampschulte M,Kovtun A,Dürselen L,Heiss C,Lips KS

更新日期：2015-11-01 00:00:00

abstract：:The objective was to evaluate the effects of antimicrobial peptide cathelicidin-BF (C-BF) treatment on diarrhea controlling, immune responses, intestinal inflammation, and intestinal barrier function in piglets with postweaning diarrhea. In this study, fifty-four weaned piglets with diarrhea were selected and treated ...

journal_title：International immunopharmacology

authors： Feng J,Wang L,Xie Y,Chen Y,Yi H,He D

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:This study investigated some T helper cytokines' association with different ANA positive sera. METHODS:Sera of 53 ANA-positive subjects (11 were stained of homogeneous pattern, 12 of speckled particle pattern, 9 of nucleolar pattern, 15 of centromere pattern, and 6 of the peripheral nuclear type) were collec...

journal_title：International immunopharmacology

authors： Hu J,Zhang Y,Liu X,Wei L,Zhang D

更新日期：2015-02-01 00:00:00

abstract：:A novel method of large-scale chromatography has been developed to improve recovery and purity of immunoglobulin G (IgG) from pooled plasma. The current study compares safety, toxicity and efficacy of two intravenous immunoglobulin products: a novel formulation, IGIV caprylate/chromatography (IGIV-C; Gamunex, 10%) and...

journal_title：International immunopharmacology

authors： Roifman CM,Schroeder H,Berger M,Sorensen R,Ballow M,Buckley RH,Gewurz A,Korenblat P,Sussman G,Lemm G

更新日期：2003-09-01 00:00:00

abstract：:Water-soluble acidic polysaccharides from the cell walls of Ulva rigida are mainly composed of disaccharides that contain glucuronic acid and sulphated rhamnose. The structure of disaccharides resembles that of glycosaminoglycans (GAGs) as they both contain glucuronic acid and sulphated sugars. Glycosaminoglycans occu...

journal_title：International immunopharmacology

authors： Leiro JM,Castro R,Arranz JA,Lamas J

更新日期：2007-07-01 00:00:00

abstract：:Cathepsin K (Cat K) is the major cysteine protease expressed in osteoclast and is thought to play a key role in matrix degradation during bone resorption. It is shown that the intracellular maturation of Cat K was prevented by the cAMP antagonist, Rp-cAMP, and the protein kinase A (PKA) inhibitors of KT5720 and H89. I...

journal_title：International immunopharmacology

authors： Park YG,Kim YH,Kang SK,Kim CH

更新日期：2006-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease. Gallium nitrate has been reported to reserve immunosuppressive activities. Therefore, we assessed the therapeutic effects of gallium nitrate in the mouse model of developed type II collagen-induced arthritis (CIA). CIA was induced by bovine type I...

journal_title：International immunopharmacology

authors： Choi JH,Lee JH,Roh KH,Seo SK,Choi IW,Park SG,Lim JG,Lee WJ,Kim MH,Cho KR,Kim YJ

更新日期：2014-05-01 00:00:00

abstract：:Nerve growth factor (NGF) has been shown to protect the viability of kidney cells in acute phase of renal damage. However, since the half-life of NGF is very short, it is too large to pass the blood-brain barrier and rapidly transported to the liver for catabolizing its use in therapy is limited. 4-Methylcatechol (4MC...

journal_title：International immunopharmacology

authors： Gezginci-Oktayoglu S,Coskun E,Ercin M,Bolkent S

更新日期：2018-11-01 00:00:00

abstract：:In search of a potent immunomodulator to be used as an immunoprophylactic agent and as adjunct to chemotherapy against Leishmania infection, two analogs of muramyl dipeptide, viz. N.Ac-norMur-MeVal-D-isoGln (86/448) and N.AcMur-Acc-D-isoGln (89/729) were evaluated for desired activity. Effect of these peptides on cell...

journal_title：International immunopharmacology

authors： Puri A,Sahai R,Haq W,Zaidi A,Guru PY,Tripathi LM,Srivastava VM

更新日期：2005-06-01 00:00:00

abstract：:Problem due to disc degeneration is frequently found in the aging population. However, severe pain and accompanying end plate inflammation is only found in a small subset of patients, who can be of a younger age than most people with severe disc degeneration, with no apparent cause. We hypothesized that deficiencies i...

journal_title：International immunopharmacology

authors： Xu C,Zhang M,Li K,Ni M,Bai Y,Zhang J,Song X,Wang J

更新日期：2019-05-01 00:00:00

abstract：:It is known that the tissue kallikrein-kinin system is located in the cardiac tissue, and the lack of this system in the cardiac tissue might induce cardiac dysfunctions. In this study, we investigated the potential role of tissue kallikrein and Trasylol, an inhibitor of tissue kallikrein, on survival time with acute ...

journal_title：International immunopharmacology

authors： Sharma JN,Abbas SA,Yusof AP,Shah RP

更新日期：2003-03-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an inflammatory disease with symmetric polyarthritis. IL-6 and NLRP3 inflammasome in macrophages contribute to the pathogenesis of RA. This study aimed to investigate the relationship between IL-6 and the NLRP3 inflammasome in RA. Here, we found that IL-6 inhibition reduced NLRP3 inflammas...

journal_title：International immunopharmacology

authors： Wang H,Wang Z,Wang L,Sun L,Liu W,Li Q,Wang J

更新日期：2020-11-01 00:00:00

abstract：:Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. Clinical trial studies in cancer patients have s...

journal_title：International immunopharmacology

authors： Zhao D,Plotnikoff N,Griffin N,Song T,Shan F

更新日期：2016-08-01 00:00:00

abstract：:There is increasing appreciation of the critical pathogenic role of IL-17 in inflammation and autoimmune diseases, which could be produced from both adaptive Th17 cells and innate γδ T cells. Existing evidences suggest that IL-2 is important for in vivo accumulation of IL-17+ γδ T cells, leaving the mechanisms still e...

journal_title：International immunopharmacology

authors： Li T,Zhou Y,Sun X,Bian Y,Wang K,Guo Q,Wang Q,Qiu F

更新日期：2020-09-01 00:00:00

abstract：:To study the intramolecular signal transduction, we performed single point and cassette mutations in transmembranal and intracellular regions of the bradykinin B2 receptor. We studied the influence of the two intramembranal Cys residues at positions 304 and 348, the role of Arg at position 177 in the highly conserved ...

journal_title：International immunopharmacology

authors： Mueller S,Liebmann C,Reissmann S

更新日期：2002-12-01 00:00:00

abstract：:Glycopyrronium bromide (GB) is a muscarinic receptor antagonist that has been used as a long-acting bronchodilator in chronic obstructive pulmonary disease (COPD) patients. The aim of this study was to investigate the anti-inflammatory activity of inhaled GB in a cigarette smoke-induced acute lung inflammation mouse m...

journal_title：International immunopharmacology

authors： Shen LL,Liu YN,Shen HJ,Wen C,Jia YL,Dong XW,Jin F,Chen XP,Sun Y,Xie QM

更新日期：2014-02-01 00:00:00

abstract：:The medical lead, so-called Cumaside, was created on the basis of triterpene oligoglycosides from the Far-Eastern edible sea cucumber (holothurian) Cucumaria japonica and its immunomodulatory properties were studied. The haemolytic activity of Cumaside was significantly reduced in comparison with original glycosides d...

journal_title：International immunopharmacology

authors： Aminin DL,Pinegin BV,Pichugina LV,Zaporozhets TS,Agafonova IG,Boguslavski VM,Silchenko AS,Avilov SA,Stonik VA

更新日期：2006-07-01 00:00:00