当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Knockdown of hepatic aquaglyceroporin-9 alleviates high fat diet-induced non-alcoholic fatty liver disease in rats.

Knockdown of hepatic aquaglyceroporin-9 alleviates high fat diet-induced non-alcoholic fatty liver disease in rats.

Abstract：

:Non-alcoholic fatty liver disease (NAFLD) has emerged as a common public health problem that can progress to end-stage liver disease. Although the function of aquaglyceroporin-9 (AQP9) as a glycerol channel has been proven, the mechanism of AQP9 in the development of NAFLD is poorly understood. To investigate the effect of hepatic glycerol uptake inhibition, we utilized a lentivirus-associated RNA interference technique to knock down the expression of hepatic AQP9 in high fat diet (HFD)-induced NAFLD in rodents. Male Sprague-Dawley rats were fed with a standard chow diet or HFD for 8 weeks. Rats fed a HFD were separated into 3 groups: HFD, control and transfection group, which were injected with equivalent amounts of PBS, lentivirus-scramble and lentivirus-shRNA-AQP9 through the hepatic portal vein. The results showed a remarkable decrease in the expression of AQP9 mRNA and protein in liver for the transfection group. Furthermore, less hepatic steatosis occurred when compared to the HFD and control groups after 8weeks. Our results indicate a potential role for AQP9 in the pathogenesis of hepatic steatosis.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Cai C,Wang C,Ji W,Liu B,Kang Y,Hu Z,Jiang Z

doi

10.1016/j.intimp.2013.01.020

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

550-6

issue

3

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(13)00036-2

journal_volume

15

pub_type

杂志文章

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