IL-6 promotes collagen-induced arthritis by activating the NLRP3 inflammasome through the cathepsin B/S100A9-mediated pathway.

abstract：:Increasing evidence is now available showing that CD1-restricted T cell responses against non-peptide mycobacterial antigens could play a role in the immune resistance against tuberculosis. BCG, widely used in anti-tubercular vaccination, shares various constituents with Mycobacterium tuberculosis, but does not provid...

journal_title：International immunopharmacology

authors： Prete SP,Giuliani A,D'Atri S,Graziani G,Balduzzi A,Oggioni MR,Iona E,Girolomoni G,Bonmassar L,Romani L,Franzese O

更新日期：2007-03-01 00:00:00

abstract：:The immune system is a very diverse system of the host that evolved during evolution to cope with various pathogens present in the vicinity of environmental surroundings inhabited by multicellular organisms ranging from achordates to chordates (including humans). For example, cells of immune system express various pat...

journal_title：International immunopharmacology

authors： Vijay K

更新日期：2018-06-01 00:00:00

abstract：:Apoptotic pathways play an important role in Mycobacterium tuberculosis-infected macrophages. Sirt1 is a member of the deacetylase family that is known to promote apoptosis resistance in many mammalian cells. However, the apoptotic role of Sirt1 in the process of M. tuberculosis infection remains unclear. With the hel...

journal_title：International immunopharmacology

authors： Yang H,Chen J,Chen Y,Jiang Y,Ge B,Hong L

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Neuroinflammation in the spinal cord following acute brachial plexus injury (BPI) remains a vital cause that leads to motor dysfunction and neuropathic pain. In this study, we aim to explore the role of long non-coding RNA JHDM1D antisense 1 (JHDM1D-AS1) in mediating BPI-induced neuroinflammation and neurona...

journal_title：International immunopharmacology

authors： Liu LP,Zhang J,Pu B,Li WQ,Wang YS

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Activation of nuclear factor-kappa B (NF-κB), which controls transcription of various pro-inflammatory cytokine genes, has been shown to play a critical role in the pathogenesis of ulcerative colitis (UC). Parthenolide, a sesquiterpene lactone compound isolated from extracts of the herb Feverfew (Tanacetum p...

journal_title：International immunopharmacology

authors： Zhao ZJ,Xiang JY,Liu L,Huang XL,Gan HT

更新日期：2012-01-01 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative disease characterized by synovium inflammation and articular cartilage damage. The aberrant expression profile of microRNAs (miRNAs) has been implicated in the cartilage of patients with OA. However, how microRNAs carried by exosomes derived from mesenchymal stem cells (MSCs) asso...

journal_title：International immunopharmacology

authors： Jin Z,Ren J,Qi S

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes have been widely applied in disease therapies. However, the role of BMSCs-derived exosomes in depression remains obscure. This study aims to explore the mechanism of BMSCs-derived exosomal microRNA-26a (miR-26a) on hippocampal neuronal injury of depr...

journal_title：International immunopharmacology

authors： Guo H,Huang B,Wang Y,Zhang Y,Ma Q,Ren Y

更新日期：2020-02-20 00:00:00

abstract：:To evaluate the effects of pirfenidone in the treatment of HUVEC using an in vitro model and on rat corneal wound healing, edema, cornea neovascularization (CNV) and inflammation after alkali burn in vivo model. In vitro, CCK-8 assay was used to detect the effect of pirfenidone on the viability of HUVECs. The effects ...

journal_title：International immunopharmacology

authors： Jiang N,Ma M,Li Y,Su T,Zhou XZ,Ye L,Yuan Q,Zhu P,Min Y,Shi W,Xu X,Lv J,Shao Y

更新日期：2018-11-01 00:00:00

abstract：:Recent studies showed that Madecassoside (MAD), a pentacyclic triterpene isolated from Centella asitica (L.), was used as a therapeutic agent in wound healing and also as an anti-inflammatory, anti-oxidative activities and anti-aging agent. However, its role in cancer has not been elucidated. In our present study, hep...

journal_title：International immunopharmacology

authors： Li Z,You K,Li J,Wang Y,Xu H,Gao B,Wang J

更新日期：2016-04-01 00:00:00

abstract：:IL-36 cytokines (IL-36Ra, IL-36α, IL-36β and IL-36γ) belong to the IL-1 family and have been linked to several autoimmune diseases. However, little is known about the relationships between systemic lupus erythematosus (SLE) and IL-36 cytokines. In this study, serum IL-36 cytokine levels were determined by enzyme-linke...

journal_title：International immunopharmacology

authors： Mai SZ,Li CJ,Xie XY,Xiong H,Xu M,Zeng FQ,Guo Q,Han YF

更新日期：2018-05-01 00:00:00

abstract：:Joint inflammation is a key player in the pathogenesis of osteoarthritis (OA). Imperatorin, a plant-derived small molecule has been reported to have anti-inflammatory properties; however, its effect on chondrocytes is not known. Here, we investigated the effects of Imperatorin on interleukin-1β (IL-1β) induced express...

journal_title：International immunopharmacology

authors： Ahmad N,Ansari MY,Bano S,Haqqi TM

更新日期：2020-08-01 00:00:00

abstract：:Glucocorticoids (GC) are frequently used for therapy of various inflammatory lung diseases by either systemic or inhalative application. Because the oral application often has various side effects and because the inhalative application is not as potent, new formulations of GCs are required. We evaluated the effect of ...

journal_title：International immunopharmacology

authors： Frankenberger M,Häussinger K,Ziegler-Heitbrock L

更新日期：2005-02-01 00:00:00

abstract：:Acute lung injury (ALI) is an excessive and uncontrolled inflammatory response in lung, of which remains the leading cause of morbidity and mortality in worldwide. Chikusetsusaponin V (CsV), a bioactive compounds derived from Panacis Japonica, has been reported to have anti-inflammatory effects. However, it is still u...

journal_title：International immunopharmacology

authors： Su K,Zhang G,Zhang X,Jiang W

更新日期：2019-05-01 00:00:00

abstract：:Regulatory T cells (Treg), formerly known as suppressor T cells, are essential for maintaining self-tolerance as well as immune homeostasis. Lack of Treg or normal function of Treg often leads to lymphoproliferative syndrome and autoimmunity in human and mouse. The chromatin remodeling BAF complex regulates gene expre...

journal_title：International immunopharmacology

authors： Jani A,Chi T,Wan YY

更新日期：2009-05-01 00:00:00

abstract：:The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, apoptosis, and angiogenesis. We identified dihydrotanshinone I as an inhibitor of NF-κB activation through our research on Salvia miltiorrhiza Bunge. In this study, we found that dihydrotanshinone...

journal_title：International immunopharmacology

authors： Wang F,Ma J,Wang KS,Mi C,Lee JJ,Jin X

更新日期：2015-09-01 00:00:00

abstract：:Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities. In this study, we tested the in vivo effect of AC-PS on immune function by evalua...

journal_title：International immunopharmacology

authors： Chen YJ,Cheng PC,Lin CN,Liao HF,Chen YY,Chen CC,Lee KM

更新日期：2008-03-01 00:00:00

abstract：:Isoliquiritigenin (isoLQ), a chalcone found in licorice, has shown a variety of biological activity including anti-inflammatory and antioxidative effects, and the distribution of isoLQ in gastrointestinal tract was higher than any other tissues. Thus, we evaluated whether or not isoLQ attenuated the dextran sulfate so...

journal_title：International immunopharmacology

authors： Choi YH,Bae JK,Chae HS,Choi YO,Nhoek P,Choi JS,Chin YW

更新日期：2016-02-01 00:00:00

abstract：:1,25-dihydroxyvitaminD3 [1,25(OH)2D3] modulates both the innate and adaptive immunity in tuberculosis. We explored the effect of 1,25(OH)2D3 on cytolytic molecules like perforin, granulysin, and granzyme-B in T-cells and natural killer cells during M. tuberculosis (Mtb) infection. Peripheral blood mononuclear cells (P...

journal_title：International immunopharmacology

authors： Afsal K,Selvaraj P,Harishankar M

更新日期：2018-09-01 00:00:00

abstract：:Understanding of oligodendrocyte precursor cells and their role in the generation of oligodendrocytes in developing and adult rodents has been considered, particularly much less is known about aged-rodent oligodendrocyte precursor cells and their cell lineage. In this present study, we have developed oligodendrocyte c...

journal_title：International immunopharmacology

authors： Kobayashi J,Seiwa C,Sakai T,Gotoh M,Komatsu Y,Yamamoto M,Fukutake M,Matsuno K,Sakurai Y,Kawano Y,Asou H

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Mesenchymal Stem Cells (MSCs) can interact with and modulate the functions of all immune cells, suppressing both the innate and adaptive immune responses. Currently, most of the in vitro studies which have led to the description of MSC properties have resulted from MSC culture in the presence of fetal bovine se...

journal_title：International immunopharmacology

authors： Silva-Carvalho AÉ,Neves FAR,Saldanha-Araujo F

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate the effects of intra-articular botulinum toxin. METHODS:Osteoarthritis was induced in both knees of 20 rabbits by transecting the anterior cruciate ligament under intramuscular anesthesia with ketamine and xylazine. Botulinum toxin, at a dose of 2.5 microg/ml (0.6 ml) and physi...

journal_title：International immunopharmacology

authors： Namazi H

更新日期：2006-11-01 00:00:00

abstract：UNLABELLED:A prospective study was performed to evaluate low dose Anti-Thymocyte Globulin (ATG) and Rituximab along with high dose Sirolimus as induction agents for reducing the incidence of acute rejection in renal transplantation. 66 patients who were to undergo live renal transplantation were divided into the low ri...

journal_title：International immunopharmacology

authors： Ravichandran P,Natrajan T,Jaganathan R

更新日期：2006-12-20 00:00:00

abstract：:Pulmonary exposure of rodents to porcine pancreatic elastase (PPE) induces lesions that morphologically resemble human panacinar emphysema. However, there has been little work on the comprehensive analysis of this model. The present study was designed to extensively examine the biological effects of PPE on inflammatio...

journal_title：International immunopharmacology

authors： Inoue K,Koike E,Takano H

更新日期：2010-11-01 00:00:00

abstract：:The inner surface of the intestinal tract possesses a large area of mucosal membranes, and the intestinal epithelial cells exist at the interface between an antigen-rich lumen and a lymphocyte-rich lamina propria. The crosstalk that occurs between these compartments serves to maintain intestinal homeostasis, and the c...

journal_title：International immunopharmacology

authors： Matsumoto T,Moriya M,Sakurai MH,Kiyohara H,Tabuchi Y,Yamada H

更新日期：2008-04-01 00:00:00

abstract：:Tree nuts are among "Big Eight" and have been reported globally for causing allergy. Buchanania lanzan (Bl) is one of the major tree nuts consumed by Indian population. However, very little is known about B. lanzan's induced allergic manifestation. Therefore, evaluation of it's allergenic potential was undertaken. Bl-...

journal_title：International immunopharmacology

authors： Kumar S,Sharma A,Gupta RK,Verma AK,Dwivedi PD

更新日期：2018-10-01 00:00:00

abstract：:This study investigated apoptotic mechanisms of down-expression vascular endothelial growth factor (VEGF) by short interfering RNA (siRNA) in human breast cancer MCF-7 cells. Human breast cancer cells were evaluated for the expression of VEGF and VEGF receptor 2 (VEGFR-2). siRNA targeting VEGF mRNA were chemically syn...

journal_title：International immunopharmacology

authors： Ge YL,Zhang X,Zhang JY,Hou L,Tian RH

更新日期：2009-04-01 00:00:00

abstract：:Avian thymic hormone (ATH) is a β-parvalbumin produced by epithelial cells in the thymic cortex and in the eyes of chickens. Chicken parvalbumin 3 (CPV3) is a homologous protein produced in the thymus and in hair cells of the chicken ear. ATH circulates in the blood on a five-day cycle and stimulates cell-mediated imm...

journal_title：International immunopharmacology

authors： Novak Kujundžić R,Steffens WL,Brewer JM,Henzl MT,Ragland WL

更新日期：2013-02-01 00:00:00

abstract：:Salicylic acid (aspirin) is a widely used pharmacological agent with immunodmodulatory properties. Dendritic cells are key regulators of the immune response, and are capable of inducing hyporesponsiveness and regulatory activity in CD4+ T-cells. We have demonstrated that aspirin-treated dendritic cells are effective a...

journal_title：International immunopharmacology

authors： Buckland M,Jago C,Fazekesova H,George A,Lechler R,Lombardi G

更新日期：2006-12-20 00:00:00

abstract：:Hypercapnia is known to have immunoregulatory effects within the lung. Cell culture systems demonstrate this in both macrophages and alveolar cell lines, suggesting that the alveoli are affected by changes in CO2 levels. We hypothesized that hypercapnia would also modulate human bronchial epithelial cell immune respon...

journal_title：International immunopharmacology

authors： Schneberger D,Cloonan D,DeVasure JM,Bailey KL,Romberger DJ,Wyatt TA

更新日期：2015-07-01 00:00:00

abstract：:Resveratrol is a polyphenol abundantly found in red grape skin and is effective against antiaging and anti-inflammation associated with immune responses. In this study, we have investigated the effect of resveratrol on skin lesion, high mobility group box (HMGB)1 and inflammation pathway in an atopic dermatitis (AD) m...

journal_title：International immunopharmacology

authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Nomoto M,Miyashita S,Suzuki K,Watanabe K

更新日期：2014-12-01 00:00:00