The role of pirfenidone in alkali burn rat cornea.

abstract：:Berberine (BBR), one of the main bioactive compounds in Rhizoma coptidis, has multiple pharmacological activities. It has been reported that 8-cetylberberine (8-BBR-C16) has increased anti-microbial property in vivo and a higher bioavailability in hamsters. Therefore, in the present study, we used apolipoprotein E-def...

journal_title：International immunopharmacology

authors： Feng M,Zou Z,Zhou X,Hu Y,Ma H,Xiao Y,Li X,Ye X

更新日期：2017-02-01 00:00:00

abstract：:The protective effects of genipin against lipopolysaccharide (LPS)-induced acute lung injury (ALI) have been reported; however, the mechanism is unclear. Genipin performs its pharmacological effects via activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. In...

journal_title：International immunopharmacology

authors： Luo X,Lin B,Gao Y,Lei X,Wang X,Li Y,Li T

更新日期：2019-11-01 00:00:00

abstract：:Lipopolysaccharide stimulates the intestinal microbiome to activate phosphoinositide 3 kinase (PI3K) signaling via several pathways; however, the direct effect that PI3K has on the intestinal bacterial community remains unclear. Herein, we investigate changes in the colonic microbiome of colitis PI3Kγ-knockout (PI3Kγ-...

journal_title：International immunopharmacology

authors： Li Y,Chen QQ,Yuan J,Chen Z,Du HT,Wan J

更新日期：2020-02-01 00:00:00

abstract：:MOTS-c (mitochondrial open-reading-frame of the twelve S rRNA-c), a mitochondrial-derived 16-amino acid peptide, targets the methionine-folate cycle, increases 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) levels, and eventually activates AMP-activated protein kinase (AMPK). AMPK activation can attenuate neutr...

journal_title：International immunopharmacology

authors： Xinqiang Y,Quan C,Yuanyuan J,Hanmei X

更新日期：2020-03-01 00:00:00

abstract：:Monocytes and macrophages of individuals with allergic diseases express increased levels of the low-affinity IgE receptors (FcepsilonRII or CD23) on their surfaces. The cross-linking of CD23-bound IgE antibody by allergen activates the cells to release inflammatory mediators. In mast cells, the binding of IgE to the h...

journal_title：International immunopharmacology

authors： Ezeamuzie CI,Al-Attiyah R,Shihab PK,Al-Radwan R

更新日期：2009-08-01 00:00:00

abstract：:Bee venom (BV) has been known to inhibit proliferation and induce apoptosis in cancer cells. However, the molecular mechanisms involved in BV-induced apoptosis are still uncharacterized in human leukemic cells. In the present study, we report that BV induces apoptosis in leukemic U937 cells through downregulation of E...

journal_title：International immunopharmacology

authors： Moon DO,Park SY,Heo MS,Kim KC,Park C,Ko WS,Choi YH,Kim GY

更新日期：2006-12-05 00:00:00

abstract：:Our previous work showed that SEP, a novel glucan isolated from the eggs of sea urchins, Strongylocentrotus nudus, had remarkable anti-tumor activity. To elucidate the mechanism of the anti-tumor activity, the immunomodulatory activity of SEP was investigated. The in vivo experiment results showed that SEP remarkably ...

journal_title：International immunopharmacology

authors： Liu C,Xi T,Lin Q,Xing Y,Ye L,Luo X,Wang F

更新日期：2008-12-20 00:00:00

abstract：:Osthole has been reported to possess a variety of pharmacological activities, such as antiinflammatory effect. In the present study, we have investigated the effect of osthole on lung inflammation associated with carrageenan-induced pleurisy in rats. The result showed that osthole could inhibit significantly pleural e...

journal_title：International immunopharmacology

authors： Li Z,Ji H,Song X,Hu J,Han N,Chen N

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Fibrinogen-like protein 2 (FGL2), a member of the fibrinogen superfamily, has been described to augment immunosuppression in gliomas. However, the precise clinical molecular features and the prognostic relevance of FGL2 in gliomas remain unclear. Therefore, a comprehensive analysis of the role of FGL2 in gli...

journal_title：International immunopharmacology

authors： Song Z,Wang Y,Du Y,Zhang Z,Yuan Y

更新日期：2020-11-01 00:00:00

abstract：:Antrodia camphorata (AC) is a commonly used fungus in folk medicine for the treatment of viral hepatitis and cancer. AC polysaccharides (AC-PS) are reported to possess anti-inflammatory, anti-hepatitis B virus, and anticancer activities. In this study, we tested the in vivo effect of AC-PS on immune function by evalua...

journal_title：International immunopharmacology

authors： Chen YJ,Cheng PC,Lin CN,Liao HF,Chen YY,Chen CC,Lee KM

更新日期：2008-03-01 00:00:00

abstract：:An expansion of regulatory T cells (Tregs) in ankylosing spondylitis (AS) was observed. However, AS patients continue to exhibit aberrant inflammation. In this study, we collected PBMCs from 26 AS patients and 26 healthy controls, and investigated the functional capacity of Treg cells from these subjects. In AS patien...

journal_title：International immunopharmacology

authors： Wang M,Liu C,Bond A,Yang J,Zhou X,Wang J,Ji B

更新日期：2018-06-01 00:00:00

abstract：:Azithromycin (AZM) is a macrolide antibiotic that exhibits anti-inflammatory activity aside from its antimicrobial effect, a feature that may ameliorate certain inflammatory disorders and prevent graft-versus-host disease in patients receiving stem cell transplantation. In the present study, we investigated the abilit...

journal_title：International immunopharmacology

authors： Lin SJ,Kuo ML,Hsiao HS,Lee PT

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Data on therapeutic drug monitoring of voriconazole in elderly patients are limited. Impaired liver function and an inflammatory state in elderly individuals are hypothesized to impact the voriconazole serum level. METHODS:A total of 166 adult patients (317 trough concentrations) who underwent voriconazole ...

journal_title：International immunopharmacology

authors： Cheng L,Xiang R,Liu F,Li Y,Chen H,Yao P,Sun F,Xia P

更新日期：2020-01-01 00:00:00

abstract：:The effects of TGF-β on dendritic cells (DCs) in the tumor microenvironment are not well-understood. In this study, we investigated the effect of TGF-β on the induction of programmed death ligand-1 (PD-L1) expression in DCs and the underlying mechanism, and we further investigated the influence of the DCs with PD-L1 e...

journal_title：International immunopharmacology

authors： Song S,Yuan P,Wu H,Chen J,Fu J,Li P,Lu J,Wei W

更新日期：2014-05-01 00:00:00

abstract：:MALT lymphoma-translocation protein 1 (Malt1) protease activity is triggered by stimulation of various immune receptors. Activation of Malt1 protease induces cleavage of negative regulators for immune responses, resulting in lymphocytes activation. Although Malt1 protease mediates the signaling process downstream of t...

journal_title：International immunopharmacology

authors： Nakamura Y,Yokoyama K,Igaki K,Tsuchimori N

更新日期：2018-03-01 00:00:00

abstract：:The Big Potassium (BK) ion channel is commonly known by a variety of names (Maxi-K, KCNMA1, slo, stretch-activated potassium channel, KCa1.1). Each name reflects a different physical property displayed by this single ion channel. This transmembrane channel is found on nearly every cell type of the body and has its own...

journal_title：International immunopharmacology

authors： Ge L,Hoa NT,Wilson Z,Arismendi-Morillo G,Kong XT,Tajhya RB,Beeton C,Jadus MR

更新日期：2014-10-01 00:00:00

abstract：:Psoriasis is an autoimmune skin disease caused by interactions between keratinocytes and immune cells, such as macrophages. CD200 is expressed on the surface of various cell types, and its receptor, CD200R1, belongs to a family of immunosuppressive receptors that are mainly expressed on myeloid cells. CD200/CD200R1 si...

journal_title：International immunopharmacology

authors： Li D,Wang Y,Tang L,Jin X,Xia C,Xu H,Hu J

更新日期：2020-01-01 00:00:00

abstract：:B cell activating factor (BAFF), a member of the tumor necrosis factor family, is critical to B cell survival, proliferation, maturation, and immunoglobulin secretion and to T cell activation. In the present study, the full-length cDNA of BAFF from the South African clawed frog (Xenopus laevis, designated xlBAFF) was ...

journal_title：International immunopharmacology

authors： Yang L,Zhou L,Zong X,Cao X,Ji X,Gu W,Zhang S

更新日期：2013-03-01 00:00:00

abstract：:Serine protease granzymes (GZM) are key effector molecules of granule-mediated cytotoxicity of NK cell, but the requirement for their expression regulation remains largely undefined. In this study, it was showed that IL-2, IL-12, IL-15 and IFNalpha differently regulated the expression of granzymes in NK cells. Althoug...

journal_title：International immunopharmacology

authors： Zhang B,Zhang J,Tian Z

更新日期：2008-07-01 00:00:00

abstract：:It is known that the tissue kallikrein-kinin system is located in the cardiac tissue, and the lack of this system in the cardiac tissue might induce cardiac dysfunctions. In this study, we investigated the potential role of tissue kallikrein and Trasylol, an inhibitor of tissue kallikrein, on survival time with acute ...

journal_title：International immunopharmacology

authors： Sharma JN,Abbas SA,Yusof AP,Shah RP

更新日期：2003-03-01 00:00:00

abstract：:Therapeutic interventions are still limited in the treatment of liver fibrosis even though an incredible number of publications related to silymarin are produced. This is due to the complex molecular pathogenesis. Several studies pointed to the role of renin-angiotensin system (RAS) in hepatic fibrogenesis. Therefore,...

journal_title：International immunopharmacology

authors： Saber S,Goda R,El-Tanbouly GS,Ezzat D

更新日期：2018-11-01 00:00:00

abstract：:Previous work has shown that in vitro thymulin treatments have the ability to enhance natural killer (NK) cell cytotoxicity. The purpose of the experiments presented here was to examine the in vivo effects of thymulin on avian NK cell activity in response to a viral infection. Five and a half-week-old K-strain chicken...

journal_title：International immunopharmacology

authors： Oliver MA,Marsh JA

更新日期：2003-01-01 00:00:00

abstract：:This study was designed to determine the level of survivin expression and its clinical significance as a prognostic factor in gastrointestinal stromal sarcoma (GIST). Twenty patients (12 males and 8 females) ranging in age from 25 to 72, with a median age of 53 were evaluated. Failure of TKI treatment was higher in th...

journal_title：International immunopharmacology

authors： Baykara M,Akkus M,Yildiz R,Gonul II,Dursun A,Coskun U,Benekli M,Sevinc A,Dane F,Buyukberber S

更新日期：2011-12-01 00:00:00

abstract：:Many edible mushrooms have become attractive as "health foods" and as source materials for immunomodulators. To increase our insight in the immune-modulatory properties of a polysaccharide of the oyster mushroom Pleurotus citrinopileatus, PCPS, we analyzed its effects on the function of human dendritic cells (DCs). We...

journal_title：International immunopharmacology

authors： Minato KI,Laan LC,Ohara A,van Die I

更新日期：2016-11-01 00:00:00

abstract：:Flavonoids, particularly those derived from plants, harbor biological effects such as anti-inflammation and the inhibition of cancer progression. In the present study, we investigated the effects of 10 kinds of flavonoids isolated from Nepalese propolis on the LPS signaling pathway in order to clarify their anti-infla...

journal_title：International immunopharmacology

authors： Funakoshi-Tago M,Ohsawa K,Ishikawa T,Nakamura F,Ueda F,Narukawa Y,Kiuchi F,Tamura H,Tago K,Kasahara T

更新日期：2016-11-01 00:00:00

abstract：:A high Treg/CD8 T cell ratio in ovarian carcinoma was negatively associated with the prognosis of the patients. The human follicular regulatory T (Tfr) cells are a newly characterized subset of Treg cells with features of both follicular helper T (Tfh) cells (CXCR5+) and canonical Treg cells (CD25+Foxp3+). The role of...

journal_title：International immunopharmacology

authors： Li L,Ma Y,Xu Y

更新日期：2019-03-01 00:00:00

abstract：:Butyrylcholinesterase (BChE) degrades acetylcholine in addition to acetylcholinesterase (AChE) which is involved in embryonic development of limbs. Since BChE is expressed by osteoblast-like cells we asked whether it is functional in adult bone remodeling. We addressed this issue by analyzing BChE gene-deficient mice ...

journal_title：International immunopharmacology

authors： Haupt M,Kauschke V,Sender J,Kampschulte M,Kovtun A,Dürselen L,Heiss C,Lips KS

更新日期：2015-11-01 00:00:00

abstract：:Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers ...

journal_title：International immunopharmacology

authors： Hou L,Wang T,Sun J

更新日期：2015-10-01 00:00:00

abstract：:Dermonecrotic toxin (DNT) produced by Bordetella bronchiseptica (B. bronchiseptica) can cause clinical turbinate atrophy in swine and induce dermonecrotic lesions in model mice. We know that the N-terminal of DNT molecule contains the receptor-binding domain, which facilitates binding to the target cells. However, we ...

journal_title：International immunopharmacology

authors： Wang C,Liu L,Zhang Z,Yan Z,Yu C,Shao M,Jiang X,Chi S,Wei K,Zhu R

更新日期：2015-10-01 00:00:00

abstract：:Metformin is a widely used anti-diabetic drug and increasing evidence suggests that metformin have profound cardioprotective effects under both diabetic and non-diabetic situations. The protective benefits of metformin have been proved in diabetic patients with cardiovascular complications and in experimental animals ...

journal_title：International immunopharmacology

authors： Liu G,Wu K,Zhang L,Dai J,Huang W,Lin L,Ge P,Luo F,Lei H

更新日期：2017-06-01 00:00:00