Azithromycin modulates immune response of human monocyte-derived dendritic cells and CD4+ T cells.

Abstract:

:Azithromycin (AZM) is a macrolide antibiotic that exhibits anti-inflammatory activity aside from its antimicrobial effect, a feature that may ameliorate certain inflammatory disorders and prevent graft-versus-host disease in patients receiving stem cell transplantation. In the present study, we investigated the ability of AZM to influence the function of human monocyte-derived dendritic cells (DCs) and CD4+ T cells. We found that AZM down-regulated CD80, CD86, and HLA-DR expression in lipopolysaccharide (LPS)-stimulated DCs and suppressed interleukin (IL)-6, IL-10, IL-12, and tumor necrosis factor-alpha production in these cells. In addition, AZM increased endocytosis and/or expression of Toll-like receptor (TLR)2, TLR4, and TLR9 in DCs and suppressed anti-CD3/CD28-induced CD4+ T cell proliferation and interferon-gamma production, an effect that was synergistic with dexamethasone. Finally, AZM suppressed DC-induced allogeneic T cell proliferation and cytokine production. Our study demonstrates that AZM modulates DC and CD4+ T cell function and may be of therapeutic benefit in various inflammatory disorders.

journal_name

Int Immunopharmacol

authors

Lin SJ,Kuo ML,Hsiao HS,Lee PT

doi

10.1016/j.intimp.2016.09.012

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

318-326

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(16)30386-1

journal_volume

40

pub_type

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