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Survivin expression and its potential clinical significance in gastrointestinal stromal sarcoma.

Abstract：

:This study was designed to determine the level of survivin expression and its clinical significance as a prognostic factor in gastrointestinal stromal sarcoma (GIST). Twenty patients (12 males and 8 females) ranging in age from 25 to 72, with a median age of 53 were evaluated. Failure of TKI treatment was higher in the survivin-positive group (p=0.06). The rate of metastasis was significantly higher in the survivin positive group vs. the negative group (80% vs. 30%, p=0.18). The median overall survival (OS) time was 114 (range 29-199)months, and the median disease-free survival (DFS) time was 88 (range 40-135) months. The median progression-free survival (PFS) time was 40 (range 24-55) months. Further, a comparison of patients with survivin positive versus negative tumors, revealed no significant difference for OS, DFS, and PFS (p=0.45, p=0.19, p=0.55, respectively), number of mitoses in 50 HPF (p=0.14), and tumor size (p=0.94). In conclusion, survivin was highly expressed in GISTs, although we found no correlation between survivin expression and PFS, DFS and OS, survivin may be a predictive marker in GISTs for disease progression. We believe that additional studies are warranted to determine the clinical significance of survivin expression as a prognostic or predictive marker in patients with GIST.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Baykara M,Akkus M,Yildiz R,Gonul II,Dursun A,Coskun U,Benekli M,Sevinc A,Dane F,Buyukberber S

doi

10.1016/j.intimp.2011.10.005

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

2227-31

issue

12

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(11)00385-7

journal_volume

11

pub_type

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