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Maturation of dendritic cells induced by Candida beta-D-glucan.

Abstract：

:We investigated whether Candida beta-D-glucan (CSBG) alters the maturation of dendritic cells (DCs). DC phenotypes were analyzed using FACScan. The expression of surface molecules, including major histocompatibility complex (MHC) classes I and II, as well as CD80 and CD86, increased on DCs that were stimulated with lipopolysaccaride (DCs/LPS), in comparison with unstimulated bone marrow-derived DCs (BM-DCs). Furthermore, the level of surface molecule expression on DCs stimulated with CSBG (DCs/CSBG) was between that of DCs and DCs/LPS. Phagocytosis was assessed by the uptake of FITC-dextran. There were no differences in the uptake of dextran among DCs/LPS and DCs/CSBG. The ability of BM-DCs to uptake dextran was higher than that of DCs/LPS and DCs/CSBG. We analyzed the concentration of IL-12 secreted by DCs using ELISA. BM-DCs secreted a low concentration of IL-12, while DCs/LPS and DCs/CSBG secreted higher levels of IL-12 than BM-DCs. There were no remarkable differences in the concentrations of IL-12 produced by DCs/LPS and DCs/CSBG. This data suggests that CSBG may augment DC maturation.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Kikuchi T,Ohno N,Ohno T

doi

10.1016/s1567-5769(02)00084-x

keywords:

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

1503-8

issue

10

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(02)00084-X

journal_volume

2

pub_type

杂志文章

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