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A soy diet accelerates renal damage in autoimmune MRL/Mp-lpr/lpr mice.

Abstract：

:Isoflavones, which are phytoestrogens present in large quantities in soy and soy-derived products, have estrogenic activity, inhibit protein tyrosine kinase, and exert other effects in the human body. Thus, the recent spread of soy consumption in Western populations emphasizes the need to more fully understand the potential effects in the body, especially in abnormal immune conditions. In the present study, the influence of a soy diet on lupus disease in MRL/Mp-lpr/lpr (MRL/lpr) mice was investigated. Weanling female MRL/lpr mice (4 weeks) were fed a soy diet (20% soybean protein and 5% soybean oil). The soy diet exacerbated renal damage; findings in this mouse strain included accelerated proteinuria, elevated serum creatinine concentrations, and reduced creatinine clearance. No effects were detected, however, in C3H/HeN mice, which have the same H-2(k) genetic background as MRL/lpr mice do. A tendency toward an increase in thymus weight and proliferation of T cells in spleen and B cells in lymph nodes were found at the age of 16 weeks. These findings indicate that a soy diet, in comparison with a casein diet, significantly exacerbates the clinical course of this autoimmune disease. Further research on the mechanism of this effect of soy-rich diets is needed, and isoflavone supplementation for systemic lupus erythematosus patients should be carefully reevaluated.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Zhao JH,Sun SJ,Horiguchi H,Arao Y,Kanamori N,Kikuchi A,Oguma E,Kayama F

doi

10.1016/j.intimp.2005.04.011

keywords:

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

1601-10

issue

11

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(05)00112-8

journal_volume

5

pub_type

杂志文章

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