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Comparison of immunosuppressive activity of stephanoside E and its aglycone from Stephanotis mucronata in vitro.

Abstract：

:Stephanoside E (STE) and its aglycone Stephanthraniline A (STA) isolated from the stems of Stephanotis mucronata (Blanco) Merr. were evaluated for their suppressive potentials on Th1 and Th2 immune responses in vitro, and the effects of the C-3 sugar chains on their activities were discussed. STE and STA significantly inhibited Con A and LPS-induced splenocyte proliferation, and reduced the production of Th1/Th2 cytokines (IL-2, IFN-γ, IL-4, and IL-10) from Con A-stimulated splenocytes in a concentration-dependent manner. The mRNA expression levels of Th1/Th2 cytokines (IL-2, IFN-γ, IL-4, and IL-10) and transcription factors (T-bet and GATA-3) in Con A-stimulated splenocytes were also suppressed by STE and STA. The suppressive effect of STA on Th1 and Th2 immune responses in vitro was stronger than that of STE. These findings suggested that both STE and STA could simultaneously inhibit Th1/Th2 immune responses, and the glycosyl formation at the position C-3 of STA could decrease the immunosuppressive activity in vitro.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Chen F,Ni Y,Ye Y,Sun H,Li X,Xu S

doi

10.1016/j.intimp.2010.06.021

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

1153-60

issue

10

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(10)00208-0

journal_volume

10

pub_type

杂志文章

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