当前位置： SCI文献检索 > INTERNATIONAL IMMUNOPHARMACOLOGY期刊下所有文献 > Naringenin ameliorates daunorubicin induced nephrotoxicity by mitigating AT1R, ERK1/2-NFκB p65 mediated inflammation.

Naringenin ameliorates daunorubicin induced nephrotoxicity by mitigating AT1R, ERK1/2-NFκB p65 mediated inflammation.

Abstract：

:Inflammation and oxidative stress play important roles in the progression of renal damage. The natural polyphenol naringenin is known to exert potent antioxidant and anti-inflammatory effects. In this study, we have investigated the effect of naringenin on kidney dysfunction, fibrosis, endoplasmic reticulum (ER) stress, angiotensin II type I receptor (AT1R) expression and inflammation in daunorubicin (DNR) induced nephrotoxicity model. Nephrotoxicity was induced in rats by intravenous injection of DNR at a cumulative dose of 9 mg/kg. After 1 week, naringenin (20mg/kg/day. p.o) was administered daily for 6 weeks. Biochemical studies were performed to evaluate renal function. Western blotting was performed to measure the protein levels of AT1R, endothelin (ET)1, ET receptor type A (ETAR), extracellular signal-regulated kinase (ERK)1/2, nuclear factor (NF)κB p65, peroxisome proliferator activated receptor (PPAR)γ, oxidative/ER stress, apoptosis, and inflammatory markers in the kidney of DNR treated rats. Histopathological analysis was done using hemotoxylin eosin and Masson trichrome stained renal sections to investigate the structural abnormalities and fibrosis. DNR treated rats suffered from nephrotoxicity as evidenced by worsened renal function, increased blood urea nitrogen, serum creatinine levels in renal tissues and histopathogical abnormalities. Treatment with naringenin mitigated these changes. Furthermore, naringenin up regulated PPARγ and down regulated AT1R, ET1, ETAR, p-ERK1/2, p-NFκB p65, ER stress, apoptosis, and inflammatory markers. Our results suggest that naringenin has an ability to improve renal function and attenuates AT1R, ERK1/2-NFκB p65 signaling pathway in DNR induced nephrotoxicity in rats.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Suzuki K,Nakamura M,Ueno K,Watanabe K

doi

10.1016/j.intimp.2015.05.050

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

154-9

issue

1

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(15)00288-X

journal_volume

28

pub_type

杂志文章

相关文献

INTERNATIONAL IMMUNOPHARMACOLOGY文献大全
  • Is neuroimmunomodulation a future therapeutic approach for sepsis?

    abstract：:Sepsis is considered as a disease of profoundly and uncontrollably activated innate immune response against bacterial infection or their products. Thus, regulation of innate immune response plays a critical role in controlling exaggerated systemic inflammation responsible for sepsis development. However, treatment of ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2009.10.003

    authors： Kumar V,Sharma A

    更新日期：2010-01-01 00:00:00

  • Altered gene expression profiles associated with enhanced skin inflammation induced by 12-O-tetradecanoylphorbol-13-acetate in streptozotocin-diabetic mice.

    abstract：:To examine the mechanisms of diabetes-enhanced inflammation, ear inflammation was induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in streptozotocin (STZ)-injected diabetic and control mice. The inflammatory response was determined from ear thickness and histology. The mRNA expression of several inflammation-rela...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.01.007

    authors： Iba Y,Watanabe K,Ozaki K,Aozasa O,Ishizawa K,Matsuura T,Oyama H,Masukawa T

    更新日期：2013-03-01 00:00:00

  • Comparison in the effects of IL-2, IL-12, IL-15 and IFNalpha on gene regulation of granzymes of human NK cell line NK-92.

    abstract：:Serine protease granzymes (GZM) are key effector molecules of granule-mediated cytotoxicity of NK cell, but the requirement for their expression regulation remains largely undefined. In this study, it was showed that IL-2, IL-12, IL-15 and IFNalpha differently regulated the expression of granzymes in NK cells. Althoug...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.03.001

    authors： Zhang B,Zhang J,Tian Z

    更新日期：2008-07-01 00:00:00

  • Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax.

    abstract：:Apoptotic pathways play an important role in Mycobacterium tuberculosis-infected macrophages. Sirt1 is a member of the deacetylase family that is known to promote apoptosis resistance in many mammalian cells. However, the apoptotic role of Sirt1 in the process of M. tuberculosis infection remains unclear. With the hel...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.107283

    authors： Yang H,Chen J,Chen Y,Jiang Y,Ge B,Hong L

    更新日期：2021-02-01 00:00:00

  • Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK.

    abstract：:Metformin is a widely used anti-diabetic drug and increasing evidence suggests that metformin have profound cardioprotective effects under both diabetic and non-diabetic situations. The protective benefits of metformin have been proved in diabetic patients with cardiovascular complications and in experimental animals ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2017.04.002

    authors： Liu G,Wu K,Zhang L,Dai J,Huang W,Lin L,Ge P,Luo F,Lei H

    更新日期：2017-06-01 00:00:00

  • Diallyl Trisulfide can induce fibroblast-like synovial apoptosis and has a therapeutic effect on collagen-induced arthritis in mice via blocking NF-κB and Wnt pathways.

    abstract：BACKGROUND:Diallyl Trisulfide (DATS) is an organosulfur compound extracted from garlic bulb, and exerts cardioprotective, anti-inflammatory, antioxidant, antimicrobial and anticancer effects. But its role in the pathogenesis of rheumatoid arthritis (RA) is unknown. Here we explored the influence of DATS on human fibrob...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.03.024

    authors： Liang JJ,Li HR,Chen Y,Zhang C,Chen DG,Liang ZC,Shi YQ,Zhang LL,Xin L,Zhao DB

    更新日期：2019-06-01 00:00:00

  • Alterations in peripheral blood B cells in systemic lupus erythematosus patients with renal insufficiency.

    abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is one of the autoimmune diseases, believed to be closely related to hyperactivity of B cells, overproduction of autoantibodies and immune complex formation and deposition in affected tissue. The autoreactive inflammation leads to multiorgan damage with kidney dysfunction in...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106451

    authors： Wardowska A,Komorniczak M,Skoniecka A,Bułło-Piontecka B,Lisowska KA,Dębska-Ślizień MA,Pikuła M

    更新日期：2020-06-01 00:00:00

  • LOX-1 and TLR4 affect each other and regulate the generation of ROS in A. fumigatus keratitis.

    abstract：PURPOSE:To explore the relationship between LOX-1 and TLR4 in Aspergillus fumigatus (A. fumigatus) keratitis. To determine LOX-1 and TLR4 can affect each other and regulate inflammation through regulation of the generation of reactive oxygen species (ROS) in A. fumigatus keratitis. METHODS:The cornea and abdominal cav...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.09.027

    authors： Gao X,Zhao G,Li C,Lin J,Jiang N,Wang Q,Hu L,Xu Q,Peng X,He K,Zhu G

    更新日期：2016-11-01 00:00:00

  • Impact of different mesenchymal stromal cell types on T-cell activation, proliferation and migration.

    abstract：:Mesenchymal stromal cells (MSCs) isolated from different tissue sources may present distinct immunomodulatory profiles. As lymphocyte responses are a combination of several distinct steps, we evaluated and compared the impact of MSCs from different sources on the activation, proliferation and migration of T-cells. We ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.02.020

    authors： Najar M,Raicevic G,Fayyad-Kazan H,De Bruyn C,Bron D,Toungouz M,Lagneaux L

    更新日期：2013-04-01 00:00:00

  • Ketamine attenuates sepsis-induced acute lung injury via regulation of HMGB1-RAGE pathways.

    abstract：:High mobility group box protein 1 (HMGB1) and receptor for the advanced glycation end product (RAGE) play important roles in the development of sepsis-induced acute lung injury (ALI). Ketamine is considered to confer protective effects on ALI during sepsis. In this study, we investigated the effects of ketamine on HMG...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.01.021

    authors： Li K,Yang J,Han X

    更新日期：2016-05-01 00:00:00

  • Role of interleukin-23 as a biomarker in rheumatoid arthritis patients and its correlation with disease activity.

    abstract：BACKGROUND:IL-23 is a pro-inflammatory cytokine belonging to the IL-12 cytokine family. IL-23 is essential for the differentiation of Th17 lymphocytes, a subtype of T lymphocyte implicated in chronic inflammatory/autoimmune mediated diseases. Experimental models of arthritis and clinical indications have highlighted an...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2015.12.011

    authors： Zaky DS,El-Nahrery EM

    更新日期：2016-02-01 00:00:00

  • Obeticholic acid prevents carbon tetrachloride-induced liver fibrosis through interaction between farnesoid X receptor and Smad3.

    abstract：:Liver fibrosis results from sustained liver injury and is characterized by inflammation, hepatic stellate cell (HSC) activation, extracellular matrix (ECM) accumulation and liver structure destruction. The Farnesoid-X receptor (FXR) antagonizes toxic liver injury and fibrosis, yet the mechanism in liver fibrosis remai...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105911

    authors： Fan YY,Ding W,Zhang C,Fu L,Xu DX,Chen X

    更新日期：2019-12-01 00:00:00

  • 10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells.

    abstract：:Neuroinflammation, characterized by the activation of microglia and astrocytes, is important in the pathogenesis of many neurological disorders, such as Alzheimer's disease. Nonsteroidal anti-inflammatory drugs (NSAIDs), a group of chemically heterogenous medications, are used widely in the treatment of inflammation. ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106501

    authors： You M,Miao Z,Sienkiewicz O,Jiang X,Zhao X,Hu F

    更新日期：2020-07-01 00:00:00

  • Immunotherapeutic effects of cytokine-induced killer cells combined with CCL21/IL15 armed oncolytic adenovirus in TERT-positive tumor cells.

    abstract：:The effective antitumor immune responses are dependent on coordinate interaction of various effector cells. Thus, the combination of adoptive immunotherapy and target gene therapy is capable of efficiently generating a productive antitumor immune response. We investigated whether combination of cytokine-induced killer...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2016.06.028

    authors： Ye JF,Lin YQ,Yu XH,Liu MY,Li Y

    更新日期：2016-09-01 00:00:00

  • Mechanism of miRNA-based Aconitum leucostomum Worosch. Monomer inhibition of bone marrow-derived dendritic cell maturation.

    abstract：:Delvestidine (DLTD) is a monomeric compound isolated from Aconitum leucostomum Worosch, a widely used medicine for local treatment of rheumatoid arthritis (RA). Studies have shown that Aconitum leucostomum Worosch. can inhibit maturation of bone marrow-derived dendritic cells (BMDCs). Further, microRNAs (miRNAs) have ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106791

    authors： Wang YY,Liu HZ,Cao M,Wang XL,Cong S,Sun J,Jia BT,Ta-Bu-Shi NE,Bian YH,Luo L

    更新日期：2020-11-01 00:00:00

  • Efficacy and safety of CTLA-4 inhibitors combined with PD-1 inhibitors or chemotherapy in patients with advanced melanoma.

    abstract：BACKGROUND:Although immune checkpoint inhibitor monotherapy has demonstrated significant efficacy in advanced melanoma, no study has systematically evaluated the efficacy and safety of the combination regimens. In this study, we conduct a comprehensive meta-analysis to explore the efficacy and safety of CTLA-4 inhibito...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.intimp.2018.12.034

    authors： Zhang B,Zhou YL,Chen X,Wang Z,Wang Q,Ju F,Ren S,Xu R,Xue Q,Wu Q

    更新日期：2019-03-01 00:00:00

  • BPTES inhibits anthrax lethal toxin-induced inflammatory response.

    abstract：:Bacillus anthracis is a lethal agent of anthrax disease and the toxins are required in anthrax pathogenesis. The anthrax lethal toxin can trigger NLRP1b inflammasome activation and pyroptosis. Although the underlying mechanism is well understood, the medications targeting the NLRP1b inflammasome are not available in t...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2020.106664

    authors： Wang J,Yang D,Shen X,Wang J,Liu X,Lin J,Zhong J,Zhao Y,Qi Z

    更新日期：2020-08-01 00:00:00

  • C1q/TNF-related protein-9 attenuates atherosclerosis through AMPK-NLRP3 inflammasome singling pathway.

    abstract：BACKGROUNDS:C1q tumor necrosis factor-related protein 9 (CTRP9) has been suggested to exert an atheroprotective effect by modulating the inflammation, foam cell formation, endothelia and smooth muscle cell function via Adenosine Monophosphate Activated Protein Kinase (AMPK) pathway. On the other hand, the NLR Family Py...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105934

    authors： Zhang H,Gong X,Ni S,Wang Y,Zhu L,Ji N

    更新日期：2019-12-01 00:00:00

  • Macrophage-oriented cytotoxic activity of novel triterpene saponins extracted from roots of Securidaca inappendiculata.

    abstract：:It is recognized that macrophages in peripheral tissues often proliferate under pathological conditions such as tumors, inflammation and atherosclerosis. Because the growth state of macrophages is believed to be a factor regulating the pathological process of the diseases, substances that regulate macrophage growth or...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/s1567-5769(01)00126-6

    authors： Yui S,Ubukata K,Hodono K,Kitahara M,Mimaki Y,Kuroda M,Sashida Y,Yamazaki M

    更新日期：2001-10-01 00:00:00

  • Protective effect of sanguinarine on LPS-induced endotoxic shock in mice and its effect on LPS-induced COX-2 expression and COX-2 associated PGE2 release from peritoneal macrophages.

    abstract：:The quaternary ammonium salt, sanguinarine (SG) was reported to possess widespread anti-microbial and anti-inflammatory effects in experimental animals and it has been used to treat many inflammatory diseases. The aim of this study was to evaluate the anti-inflammatory effect and the possible mechanisms underlying the...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.07.017

    authors： Li W,Li H,Mu Q,Zhang H,Yao H,Li J,Niu X

    更新日期：2014-10-01 00:00:00

  • STAT1 phosphorylation and cleavage is regulated by the histamine (H4) receptor in human atopic and non-atopic lymphocytes.

    abstract：:Histamine can modulate the balance between T helper lymphocytes 1 and 2 (Th1 and Th2), and there is evidence that allergic reactions can be associated with excessive histamine production causing shifts toward Th2 responses. As signal transduction in Th-cells is specifically correlated to signal transducer and activato...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2006.06.005

    authors： Horr B,Borck H,Thurmond R,Grösch S,Diel F

    更新日期：2006-10-01 00:00:00

  • Imbalanced expression of human Tim-1 and Tim-3 in peripheral blood mononuclear cells from immune thrombocytopenia patients.

    abstract：BACKGROUND:The T-cell immunoglobulin and mucin domain-(Tim)-1 molecule and Tim-3 are mainly expressed on activated T helper (Th) 2 and Th1 cells, respectively, and have been implicated in the pathogenesis of some autoimmune diseases. Immune thrombocytopenia (ITP) is a common autoimmune disorder, and the complex dysregu...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.12.025

    authors： Zhang XM,Shan NN,Sun M,Wang X,Feng XM,Liu X,Li Y,Yuan D,Ding M

    更新日期：2014-03-01 00:00:00

  • Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-beta1.

    abstract：:The neuropharmacological properties of cocaine are known to be associated with the activation of sigma-1 receptors. Cocaine also has been shown to alter both cytokine production and HIV-1 expression in mononuclear phagocytes, including microglial cells. This study tested the hypothesis that sigma-1 receptors and trans...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.12.005

    authors： Gekker G,Hu S,Sheng WS,Rock RB,Lokensgard JR,Peterson PK

    更新日期：2006-06-01 00:00:00

  • Interleukin-1β promotes the induction of retinal autoimmune disease.

    abstract：:Interleukin-1β (IL-1β) is a potent proinflammatory cytokine that plays a critical role in initiating immunoinflammatory responses. In this study, we generated recombinant mouse IL-1β and anti-mouse IL-1β polyclonal antibodies to examine the effect of IL-1β on experimental autoimmune uveoretinitis (EAU), a mouse model ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2014.06.041

    authors： Zhao R,Zhou H,Zhang J,Liu X,Su SB

    更新日期：2014-10-01 00:00:00

  • Induction of nitric oxide synthases in primary human cultured mast cells by IgE and proinflammatory cytokines.

    abstract：:The mast cells have been suggested to be a cellular source of nitric oxide (NO) which level is increased in the pathogenesis of asthma. However, isoforms of the NO generating enzyme, nitric oxide synthase (NOS), in primary human mast cells have not been defined due to the lack of a suitable model. We hence examined di...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2008.01.019

    authors： Yip KH,Huang Y,Waye MM,Lau HY

    更新日期：2008-05-01 00:00:00

  • Combined ischemic and rapamycin preconditioning alleviated liver ischemia and reperfusion injury by restoring autophagy in aged mice.

    abstract：:Old livers are more damaged by hepatic ischemia and reperfusion (IR) injury than young livers. The aim of this study was to investigate the effects of ischemic and rapamycin preconditioning on IR injury in old livers. Young (8-week-old) and aged (60-week-old) mice were subjected to IR or a sham control procedure. The ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2019.105711

    authors： Jiang T,Zhan F,Rao Z,Pan X,Zhong W,Sun Y,Wang P,Lu L,Zhou H,Wang X

    更新日期：2019-09-01 00:00:00

  • A review on the effect of COVID-19 in type 2 asthma and its management.

    abstract：BACKGROUND:COVID-19 is considered the most critical health pandemic of 21st century. Due to extremely high transmission rate, people are more susceptible to viral infection. COVID-19 patients having chronic type-2 asthma prevails a major risk as it may aggravate the disease and morbidities. OBJECTIVE:The present revie...

    journal_title：International immunopharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.intimp.2020.107309

    authors： Ghosh S,Das S,Mondal R,Abdullah S,Sultana S,Singh S,Sehgal A,Behl T

    更新日期：2021-02-01 00:00:00

  • Taishan Pinus massoniana pollen polysaccharides promote immune responses of recombinant Bordetella avium ompA in BALB/c mice.

    abstract：:To study the effects of Taishan Pinus massoniana pollen polysaccharides (TPPPS) on Bordetella avium outer membrane protein A (ompA) recombinant protein vaccine, ompA was expressed, confirmed by Western blotting and mixed with TPPPS. Female BALB/c mice were randomly divided into six groups (I-VI). Groups I, II, and III...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2013.09.008

    authors： Zhao X,Liang M,Yang P,Guo F,Pan D,Huang X,Li Y,Wu C,Qu T,Zhu R

    更新日期：2013-11-01 00:00:00

  • Generation and characterization of a novel tetravalent anti-CD22 antibody with improved antitumor activity and pharmacokinetics.

    abstract：:The purpose of this study was to prepare a tetravalent anti-human CD22 recombinant antibody with improved antitumor activity and a half life longer than that of its divalent counterpart. We compared the ability of tetravalent vs. divalent antibody to associate/dissociate to/from CD22-positive Daudi cells, to interact ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2005.11.022

    authors： Liu XY,Pop LM,Roopenian DC,Ghetie V,Vitetta ES,Smallshaw JE

    更新日期：2006-05-01 00:00:00

  • Estradiol pretreatment attenuated nicotine-induced endothelial cell apoptosis via estradiol functional membrane receptor.

    abstract：:Cigarette smoking is highly associated with increased cardiovascular disease complications. The female population, however, manifests reduced cardiovascular morbidity. We define nicotine's effect upon human umbilical vein endothelial cells (HUVECs), determine whether estradiol might ameliorate endothelial dysfunction ...

    journal_title：International immunopharmacology

    pub_type： 杂志文章

    doi：10.1016/j.intimp.2011.01.010

    authors： Wang LL,Zhao JL,Lau WB,Zhang YQ,Qiao ZD,Wang YJ

    更新日期：2011-06-01 00:00:00