Abstract:
OBJECTIVE:Systemic lupus erythematosus (SLE) is one of the autoimmune diseases, believed to be closely related to hyperactivity of B cells, overproduction of autoantibodies and immune complex formation and deposition in affected tissue. The autoreactive inflammation leads to multiorgan damage with kidney dysfunction in the forefront. Studies on lupus nephritis (LN), affecting the majority of SLE patients, are mainly focused on cells causing local inflammation. The aim of our work was to detect alterations in more accessible peripheral blood B cells in the course of SLE focusing on the influence of renal insufficiency (RI) on those parameters. METHODS:We performed a comprehensive flow cytometry analysis of B cell subpopulations, analyzed gene expression patterns with qPCR, and examined serum cytokine levels with multiplex cytokine/chemokine assay. RESULTS:We discovered distribution of specific B cell subsets, especially CD38+ cells, plasmablasts, associated with the presence and severity of the disease. Changes in expression of MBD2, DNMT1 and APRIL genes were not only associated with activity of SLE but also were significantly changed in patients with RI. CONCLUSIONS:All these results shed new light on the role of circulating B cells, their subpopulations, function, and activity in the SLE with kidney manifestation.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Wardowska A,Komorniczak M,Skoniecka A,Bułło-Piontecka B,Lisowska KA,Dębska-Ślizień MA,Pikuła Mdoi
10.1016/j.intimp.2020.106451subject
Has Abstractpub_date
2020-06-01 00:00:00pages
106451eissn
1567-5769issn
1878-1705pii
S1567-5769(20)30451-3journal_volume
83pub_type
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
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