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Combined standard and novel immunosuppressive substances affect B-lymphocyte function.

Abstract：

:A considerable fraction of renal transplanted patients is susceptible to humoral rejection. Today well-established therapy regimens are available to control antibody-mediated rejection in the short term. Nevertheless, donor-specific antibodies persist and graft function deteriorates over time. This might be due to insufficient maintenance immunosuppression - which always consists of two to three drugs with different mechanisms of action. Since T- and B-cell functions always depend on each other in the alloimmune response it is of interest to analyze the effects of combined standard and new immunosuppressive substances with T-cell inhibitory properties on B-cell function. The effectiveness of complementary administrations of sotrastaurin, mycophenolic acid and everolimus on the activation and function of human primary B-lymphocytes was tested. Everolimus and mycophenolic acid alone and in combination proved to be highly effective in suppressing B-cell activation, whereas the proteinkinase C inhibitor sotrastaurin had an unexpected and reverse impact on various B-cell functions when applied in combination with the mammalian target of rapamycin and the inosine monophosphate dehydrogenase inhibitor.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Matz M,Lehnert M,Lorkowski C,Fabritius K,Weber UA,Mashreghi MF,Neumayer HH,Budde K

doi

10.1016/j.intimp.2013.02.025

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

718-25

issue

4

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(13)00084-2

journal_volume

15

pub_type

杂志文章

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