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Oridonin inhibits LPS-induced inflammation in human gingival fibroblasts by activating PPARγ.

Abstract：

:Oridonin, the major terpene isolated from Rabdosia rubescens, has been used as dietary supplement. Recently, it has been known to exhibit anti-inflammatory effect. This study we employed an in vitro model of LPS-stimulated human gingival fibroblasts to investigate the anti-inflammatory effects and mechanism of oridonin. Oridonin (10-30 μg/mL) was administrated 1 h before LPS treatment. The results showed that oridonin significantly inhibited inflammatory mediators PGE2, NO, IL-6, and IL-8 production. Immunoblotting experiments revealed that oridonin reduced the expression of phosphorylation levels of NF-κB p65 and IκBα. Furthermore, the expression of PPARγ was up-regulated by the treatment of oridonin. Further studies showed that PPARγ inhibitor GW9662 could reverse the inhibition of oridonin on PGE2, NO, IL-6, and IL-8 production. In conclusion, oridonin inhibited LPS-induced microglia activation through activating PPARγ.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Yu T,Xie W,Sun Y

doi

10.1016/j.intimp.2019.04.006

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

301-307

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(18)30664-7

journal_volume

72

pub_type

杂志文章

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