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Suppression of lipopolysaccharide-stimulated inducible nitric oxide synthase (iNOS) expression by a novel humulene derivative in macrophage cells.

Abstract：

:In our previous study, we reported the isolation of a novel humulene derivative, 5-hydroxyzerumbone, from Zingiber zerumbet and its inhibitory activity on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 mouse macrophage cells. This study was performed to examine its mechanism of action on the regulation of NO production. 5-Hydroxyzerumbone inhibited the expressions of iNOS mRNA and protein in a concentration-dependent manner. Treatment with 5-hydroxyzerumbone also induced the expression of heme oxygenase-1 (HO-1) in macrophage cells. In addition, 5-hydroxyzerumbone inhibited LPS-induced transcriptional activation of NF-kappaB, indicating that regulation of NF-kappaB activity might be involved in the inhibition of NO production by 5-hydroxyzerumbone. 5-Hydroxyzerumbone, however, did not affect the degradation of IkappaB-alpha and the activation of p38 and ERK in LPS-treated cells. Taken together, these results suggest that down-regulation of LPS-induced NO production by 5-hydroxyzerumbone is mediated by the suppression of iNOS expression through the modulation of NF-kappaB activation and HO-1 induction in macrophage cells.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Min HY,Kim MS,Jang DS,Park EJ,Seo EK,Lee SK

doi

10.1016/j.intimp.2009.03.005

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

844-9

issue

7-8

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(09)00100-3

journal_volume

9

pub_type

杂志文章

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