Inhibition of spleen tyrosine kinase signaling protects against acute lung injury through blockade of NADPH oxidase and IL-17A in neutrophils and γδ T cells respectively in mice.

Abstract:

:Acute lung injury (ALI) is one of the most serious complications in critically ill patients which often leads to morbidity and mortality. ALI characterized by severe inflammation of lungs occurs due to uncontrolled inflammatory immune response. However, the immunological mechanism(s) are far from being understood. The spleen tyrosine kinase (SYK), a key component of immune receptor signaling, plays a critical role in the modulation of inflammatory signaling in different immune cells. However, its role in ALI remains to be explored. Therefore, in this study, we investigated the effect of R406, a SYK inhibitor in lipopolysaccharide (LPS)-induced ALI mouse model. LPS led to increased SYK expression in neutrophils and gamma delta (γδ) T cells. This was associated with increased neutrophilic airway inflammation, vascular permeability, myeloperoxidase activity in the lung with upregulated expression of NADPH oxidase (NOX2)/MCP-1/TNF-α in neutrophils and IL-17A in γδ T cells/lung. Pulmonary inflammation was associated with higher mortality in mice with ALI. Inhibition of SYK signaling using R406 in the lung led to blockade of neutrophilic airway inflammation, vascular permeability, pro-inflammatory cytokine release and oxidative stress in innate immune cells, i.e. γδ T cells and neutrophils and the lung. R406 administered LPS group had better survival rate than LPS group. This suggests that SYK upregulation in γδ T cells and neutrophils plays an important role in inflammatory process during ALI. In conclusion, R406 exhibited a great potential to block the LPS-induced airway inflammation and mortality which could be developed as a potential future therapy in ALI.

journal_name

Int Immunopharmacol

authors

Nadeem A,Ahmad SF,Al-Harbi NO,Al-Harbi MM,Ibrahim KE,Kundu S,Attia SM,Alanazi WA,AlSharari SD

doi

10.1016/j.intimp.2018.12.062

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

39-47

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(18)30893-2

journal_volume

68

pub_type

杂志文章
  • Natural product derived immune-regulatory agents.

    abstract::We can now declare that the clinical goal of immune intervention as a therapeutic strategy for neoplastic, infectious, autoimmune and inflammatory diseases, has been achieved and in many instances obtained regulatory approval. Although, interest in and optimism for this approach has fluctuated, in the last 20years, im...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2016.02.025

    authors: Talmadge JE

    更新日期:2016-08-01 00:00:00

  • Association of ophthalmic complications in patients with sulfur mustard induced mild ocular complications and serum soluble adhesion molecules: Sardasht-Iran Cohort Study.

    abstract::The aim of this study was to evaluate possible association between ophthalmic complications in sulfur mustard (SM) exposed patients with mild ocular injuries and serum soluble adhesion molecules. Serum levels of sICAM-1, sL-selectin, sP-selectin and sE-selectin in 367 SM-exposed individuals with or without eye injurie...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2012.12.014

    authors: Ghasemi H,Yaraee R,Hassan ZM,Faghihzadeh S,Soroush MR,Pourfarzam S,Ebtekar M,Babaei M,Moaiedmohseni S,Naghizadeh MM,Askari N,Ghazanfari T

    更新日期:2013-11-01 00:00:00

  • GABA-mediated activated microglia induce neuroinflammation in the hippocampus of mice following cold exposure through the NLRP3 inflammasome and NF-κB signaling pathways.

    abstract::Chronic cold stress has long-term dramatic effects on the animal immune and neuroendocrine systems. As one of the important regions of the brain, the hippocampus is the main region involved in response to stressors. Nevertheless, the impact to the hippocampus following cold exposure and the underlying mechanism involv...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106908

    authors: Lang L,Xu B,Yuan J,Li S,Lian S,Chen Y,Guo J,Yang H

    更新日期:2020-12-01 00:00:00

  • A first of its kind quantitative functional C1-esterase inhibitor lateral flow assay for hereditary angioedema point-of-care diagnostic testing.

    abstract::Hereditary Angioedema (HAE) is a rare, autosomal dominant disease caused by mutations in SERPING1 gene leading to dysfunction/deficiency of C1-esterase inhibitor (C1-INH) protein and subsequent dysregulation of the contact system and bradykinin overproduction. As functional C1-INH (fC1-INH) levels are reduced in HAE t...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106526

    authors: Chockalingam PS,Zhou Z,Garg BK,Boehringer H,Chung R,Fait S

    更新日期:2020-06-01 00:00:00

  • Protective effects of Clematichinenoside AR against inflammation and cytotoxicity induced by human tumor necrosis factor-α.

    abstract::Clematichinenoside AR (AR), a major active ingredient extracted from traditional Chinese herb Clematis chinensis Osbeck, has been demonstrated to possess anti-inflammatory and immune-modulatory activities in the treatment of experimental rheumatoid arthritis (RA). The therapeutic potential of AR was supposed to be clo...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2019.04.010

    authors: Xiong Y,Ma Y,Kodithuwakku ND,Fang W,Liu L,Li F,Hu Y,Li Y

    更新日期:2019-10-01 00:00:00

  • SIRT1 alleviates isoniazid-induced hepatocyte injury by reducing histone acetylation in the IL-6 promoter region.

    abstract::Silent information regulator 1 (SIRT1) is a type III histone deacetylase that is related to the inhibition of the inflammatory response. The aim of this study was to investigate the regulation of SIRT1 on isoniazid-induced hepatocyte injury and the possible mechanism of histone modification. We found that compared wit...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2018.11.054

    authors: Zhang Y,Li Y,Li J,Li B,Chong Y,Zheng G,Sun S,Feng F

    更新日期:2019-02-01 00:00:00

  • Role of immune system in type 1 diabetes mellitus pathogenesis.

    abstract::The immune system is the body's natural defense system against invading pathogens. It protects the body from infection and works to communicate an individual's well-being through a complex network of interconnected cells and cytokines. This system is an associated host defense. An uncontrolled immune system has the po...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2014.06.033

    authors: Szablewski L

    更新日期:2014-09-01 00:00:00

  • The novel non-mitogenic anti-CD3 antibody, mini-yCD3, delivers a partial TCR signal.

    abstract::Previous studies indicated that a partial T-cell receptor signal delivered by non-mitogenic anti-CD3 antibodies is critical for dampening the activated T-cell response. The mini-yCD3 is a novel non-mitogenic anti-CD3 antibody based on a murine anti-human CD3 antibody yCD3. However, the mechanism by which mini-yCD3 sup...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2009.10.016

    authors: Lv M,Qiao C,Lin Z,Yu M,Hou C,Sun Y,Li Y,Feng J,Shen B

    更新日期:2010-02-01 00:00:00

  • T cell inflammation profile after surgical resection may predict tumor recurrence in HBV-related hepatocellular carcinoma.

    abstract::The most effective treatment for HBV-related hepatocellular carcinoma (HCC) is surgical removal of the tumor in early stage patients. But many such patients will develop recurrent tumor within the first 24months, which is the major cause of death. To enable the prevention and earlier detection of recurrent HCC, we inv...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2016.10.015

    authors: Song B,Zhen S,Meng F

    更新日期:2016-12-01 00:00:00

  • Evaluation of safety, efficacy, tolerability, and treatment-related outcomes of type I interferons for human coronaviruses (HCoVs) infection in clinical practice: An updated critical systematic review and meta-analysis.

    abstract:BACKGROUND:There is no vaccine or specific antiviral treatment for HCoVs infection. The use of type I interferons for coronavirus is still under great debate in clinical practice. MATERIALS AND METHODS:A literature search of all relevant studies published on PubMed, Cochrane library, Web of Science database, Science D...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.intimp.2020.106740

    authors: Yu C,Kang L,Chen J,Zang N

    更新日期:2020-09-01 00:00:00

  • Lectin from Abelmoschus esculentus reduces zymosan-induced temporomandibular joint inflammatory hypernociception in rats via heme oxygenase-1 pathway integrity and tnf-α and il-1β suppression.

    abstract::Temporomandibular joint (TMJ) disorders show inflammatory components, heavily impacting on quality of life. Abelmoschus esculentus is largely cultivated in Northeastern Brazil for medicinal purposes, having it shown anti-inflammatory activity. We evaluated A. esculentus lectin (AEL) efficacy in reducing zymosan-induce...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2016.06.012

    authors: Freitas RS,do Val DR,Fernandes ME,Gomes FI,de Lacerda JT,SantiGadelha T,de Almeida Gadelha CA,de Paulo Teixeira Pinto V,Cristino-Filho G,Pereira KM,de Castro Brito GA,Bezerra MM,Chaves HV

    更新日期:2016-09-01 00:00:00

  • Gallium nitrate ameliorates type II collagen-induced arthritis in mice.

    abstract::Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease. Gallium nitrate has been reported to reserve immunosuppressive activities. Therefore, we assessed the therapeutic effects of gallium nitrate in the mouse model of developed type II collagen-induced arthritis (CIA). CIA was induced by bovine type I...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2014.03.005

    authors: Choi JH,Lee JH,Roh KH,Seo SK,Choi IW,Park SG,Lim JG,Lee WJ,Kim MH,Cho KR,Kim YJ

    更新日期:2014-05-01 00:00:00

  • Effects of hydroxyethyl starch (130 kD) on brain inflammatory response and outcome during normotensive sepsis.

    abstract:BACKGROUND:During sepsis, the dysfunction of blood-brain barrier (BBB) was mediated by inflammation and subsequently caused sepsis-associated encephalopathy. Hydroxyethyl starch (HES, 130/0.4) is most widely used for volume replacement to maintain or improve tissue perfusion in patients with sepsis, trauma, and shock. ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2010.04.020

    authors: Feng X,Zhang F,Dong R,Wang H,Liu J,Liu X,Li W,Yao J,Xu J,Yu B

    更新日期:2010-08-01 00:00:00

  • Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice.

    abstract::Myeloid-derived suppressor cells (MDSCs) mediate tumor-associated immune suppression in both cancer patients and tumor-bearing animals. Reduction or elimination of MDSCs reduces the rate of tumor progression and improves cancer therapies that employ mechanisms of immunity. Here we show that baccatin III, which is the ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2014.06.012

    authors: Lee YH,Lee YR,Park CS,Im SA,Song S,Hong JT,Whang BY,Kim K,Lee CK

    更新日期:2014-08-01 00:00:00

  • Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K/AKT pathway in acute lung injury.

    abstract::The protective effects of genipin against lipopolysaccharide (LPS)-induced acute lung injury (ALI) have been reported; however, the mechanism is unclear. Genipin performs its pharmacological effects via activation of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. In...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2019.105842

    authors: Luo X,Lin B,Gao Y,Lei X,Wang X,Li Y,Li T

    更新日期:2019-11-01 00:00:00

  • Bone marrow mesenchymal stem cells-derived exosomes improve injury of hippocampal neurons in rats with depression by upregulating microRNA-26a expression.

    abstract:OBJECTIVE:Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes have been widely applied in disease therapies. However, the role of BMSCs-derived exosomes in depression remains obscure. This study aims to explore the mechanism of BMSCs-derived exosomal microRNA-26a (miR-26a) on hippocampal neuronal injury of depr...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106285

    authors: Guo H,Huang B,Wang Y,Zhang Y,Ma Q,Ren Y

    更新日期:2020-02-20 00:00:00

  • Acetylcholine enhances keratocyte proliferation through muscarinic receptor activation.

    abstract::Acetylcholine (ACh), a classical neurotransmitter, has been shown to be present in various non-neuronal cells, including cells of the eye, such as corneal epithelium and endothelium, and to have widespread physiological effects such as cytoskeleton reorganization, cellular proliferation, differentiation, and apoptosis...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2015.05.039

    authors: Słoniecka M,Backman LJ,Danielson P

    更新日期:2015-11-01 00:00:00

  • Oral immunogenicity of the plant proteinase bromelain.

    abstract::Bromelain is a natural mixture of proteolytic enzymes derived from pineapple stem that has been shown to have anti-inflammatory activity when administered orally. Although most proteins given orally without adjuvant (e.g., food) result in tolerance, we previously reported that long-term oral exposure to bromelain stim...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2006.08.007

    authors: Hale LP,Fitzhugh DJ,Staats HF

    更新日期:2006-12-20 00:00:00

  • B cells present skewed profile and lose the function of supporting T cell inflammation after Roux-en-Y gastric bypass.

    abstract::Bariatric surgeries, including Roux-en-Y gastric bypass (RYGB) are currently the best treatment for obesity and obesity-related comorbidities, such as type 2 diabetes. However, the underlying mechanism of bariatric surgeries is not entirely understood. Further investigations are needed to improve the success rate and ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2016.11.033

    authors: Dai X,Zhao W,Zhan J,Zeng S,Ran D,Zhang H,Song Z,Song KH,Wu L

    更新日期:2017-02-01 00:00:00

  • Polydeoxyribonucleotide ameliorates lipopolysaccharide-induced acute lung injury via modulation of the MAPK/NF-κB signaling pathway in rats.

    abstract::Acute lung injury (ALI) is characterized by disruption of the alveolar-capillary membrane resulting in pulmonary edema and accumulation of associated proteinaceous alveolar exudate. Initiation of ALI upregulates tumor necrosis factor-α (TNF-α), which activates nuclear factor-kappa B (NF-κB) and mitogen-activated prote...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2020.106444

    authors: Ko IG,Hwang JJ,Chang BS,Kim SH,Jin JJ,Hwang L,Kim CJ,Choi CW

    更新日期:2020-06-01 00:00:00

  • Scorpion venom activates natural killer cells in hepatocellular carcinoma via the NKG2D-MICA pathway.

    abstract::Previous studies have demonstrated that polypeptides extracted from scorpion venom (PESV) inhibited cell proliferation in several tumors, however, the effect on dysfunctional and exhausted natural killer cells which contribute to tumor escape from immune surveillance remain to be elucidated. In this study, we determin...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2016.03.045

    authors: Chen H,Zhidan W,Xia R,Zhaoxia W,Qing J,Qiang G,Haipeng Y,Hengxiao W

    更新日期:2016-06-01 00:00:00

  • Effects of ghrelin on pulmonary NOD2 mRNA expression and NF-κB activation when protects against acute lung injury in rats challenged with cecal ligation and puncture.

    abstract:BACKGROUND:Many studies have shown that ghrelin can down-regulate inflammatory cytokine expression via the inhibition of NF-κB activity and therefore, its administration to septic patients is considered beneficial. However, our knowledge of ghrelin's effects on the upstream activators of the NF-κB pathway, such as NOD2...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2012.04.006

    authors: Peng Z,Zhu Y,Zhang Y,Wilhelmsen K,Jia C,Jin J,Xue Q,Feng X,Zhang F,Yu B

    更新日期:2012-08-01 00:00:00

  • Progesterone suppresses Aβ42-induced neuroinflammation by enhancing autophagy in astrocytes.

    abstract::Autophagy is an intracellular catabolic mechanism essential for recycling intracellular unfolding protein and eliminating toxic protein aggregates. Several studies have shown that deficient autophagy is implicated in the development of Alzheimer's disease (AD) progression. To date, rapidly emerging evidence suggests t...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2017.11.044

    authors: Hong Y,Liu Y,Zhang G,Wu H,Hou Y

    更新日期:2018-01-01 00:00:00

  • Tear and serum MMP-9 and serum TIMPs levels in the severe sulfur mustard eye injured exposed patients.

    abstract:INTRODUCTION:Sulfur mustard (SM) intoxication produces local and systemic changes in the human body. In this study, the relationship between tear and serum matrix metalloproteinase (MMP)-9 and serum tissue inhibitors of metalloproteinases (TIMPs) are assessed in serious eye-injured SM-exposed casualties. METHODS:A gro...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2019.105812

    authors: Ghasemi H,Yaraee R,Faghihzadeh S,Ghassemi-Broumand M,Mahmoudi M,Babaei M,Naderi M,Safavi M,Ghazanfari Z,Rastin M,Zamani S,Tabasi N,Faghihzadeh E,Gharebaghi R,Hassan ZM,Mirsharif ES,Ghazanfari T

    更新日期:2019-12-01 00:00:00

  • Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats.

    abstract::Chronic low back pain due to lumbar spinal stenosis (LSS) is common, costly, mechanistically complex, and clinically challenging. However, the factors and mechanisms causing and mediating chronic pain induced by cauda equina compression remain unclear. Here, we examined the role of cyclooxygenase (COX)-2 in infiltrate...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2019.105738

    authors: Lee JY,Choi HY,Park CS,Jang C,Lee KT,Lee JY,Youn I,Yune TY

    更新日期:2019-10-01 00:00:00

  • Chromatin remodeling complex in Treg function.

    abstract::Regulatory T cells (Treg), formerly known as suppressor T cells, are essential for maintaining self-tolerance as well as immune homeostasis. Lack of Treg or normal function of Treg often leads to lymphoproliferative syndrome and autoimmunity in human and mouse. The chromatin remodeling BAF complex regulates gene expre...

    journal_title:International immunopharmacology

    pub_type: 杂志文章,评审

    doi:10.1016/j.intimp.2009.01.019

    authors: Jani A,Chi T,Wan YY

    更新日期:2009-05-01 00:00:00

  • Accumulation of cytosolic dsDNA contributes to fibroblast-like synoviocytes-mediated rheumatoid arthritis synovial inflammation.

    abstract::The accumulation of cytosolic dsDNA plays important roles in the regulation of cellular processes. However, whether cytosolic dsDNA is involved in the pathogenesis of rheumatoid arthritis (RA) is not clear. Therefore, the present study investigated the roles of cytosolic dsDNA in the modulation of inflammatory respons...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2019.105791

    authors: Wang J,Li R,Lin H,Qiu Q,Lao M,Zeng S,Wang C,Xu S,Zou Y,Shi M,Liang L,Xu H,Xiao Y

    更新日期:2019-11-01 00:00:00

  • Anti-inflammatory effect of thalidomide in paraquat-induced pulmonary injury in mice.

    abstract::Thalidomide has been used in inflammatory and autoimmune disorders due to its anti-inflammatory activity. Paraquat (PQ) poisoning causes severe lung injury. PQ-induced pulmonary inflammation and fibrosis are due to its ability to induce oxidative stress, inflammatory and fibrotic reactions. This study was designed to ...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2013.06.005

    authors: Amirshahrokhi K

    更新日期:2013-10-01 00:00:00

  • Immunomodulatory properties of Mycoplasma pulmonis. I. Characterization of the immunomodulatory activity.

    abstract::For many years, it has been recognized that Mycoplasma infection affects the host's immune system in different ways. In this work, experiments were performed to characterize the influence of Mycoplasma pulmonis infection on various immunological parameters and to follow the kinetics of their variations. A Balb/c mouse...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/s1567-5769(01)00078-9

    authors: Romero-Rojas A,Ponce-Hernández C,Ciprián A,Estrada-Parra S,Hadden JW

    更新日期:2001-09-01 00:00:00

  • DA-9601 suppresses 2, 4-dinitrochlorobenzene and dust mite extract-induced atopic dermatitis-like skin lesions.

    abstract::DA-9601 (Stillen™) is a novel anti-peptic formulation prepared from the ethanol extracts of Artemisia asiatica possessing anti-oxidative, anti-allergic and anti-inflammatory activities. However, their effect on atopic dermatitis (AD) has not been studied yet. In this study, we report that topical application of DA-960...

    journal_title:International immunopharmacology

    pub_type: 杂志文章

    doi:10.1016/j.intimp.2011.04.005

    authors: Choi EJ,Lee S,Hwang JS,Im SH,Jun CD,Lee HS,Kim SH

    更新日期:2011-09-01 00:00:00