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Ellagic acid protects Lipopolysaccharide/D-galactosamine-induced acute hepatic injury in mice.

Abstract：

:Ellagic acid, a natural polyphenol found in certain fruits, nuts and vegetables, has been reported to have anti-inflammatory, anti-tumor, and antioxidant activities. However, the effects of ellagic acid on acute hepatic injury have not been reported. In the present study, we investigated the effects of ellagic acid on Lipopolysaccharide/d-galactosamine-induced acute hepatic injury in mice. The results showed that LPS/GalN increased hepatic malondialdehyde (MDA) content, TNF-α level, serum ALT and AST levels and TNF-α level. However, these changes were attenuated by ellagic acid. Western blot analysis showed that ellagic acid inhibited LPS/GalN-induced NF-κB activation. Furthermore, ellagic acid induced the expression of Nrf2 and heme oxygenase-1. In conclusion, our results showed that ellagic acid protected against LPS/GalN-induced liver injury by enhancing the antioxidative defense system and reducing inflammatory response.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Gu L,Deng WS,Liu Y,Jiang CH,Sun LC,Sun XF,Xu Q,Zhou H

doi

10.1016/j.intimp.2014.07.005

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

341-5

issue

2

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(14)00260-4

journal_volume

22

pub_type

杂志文章

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