Capsazepine, a vanilloid receptor antagonist, inhibits the expression of inducible nitric oxide synthase gene in lipopolysaccharide-stimulated RAW264.7 macrophages through the inactivation of nuclear transcription factor-kappa B.

abstract：:A procedure was developed for the determination of low levels of the anthraquinones aloe-emodin and aloin A (barbalin) in aloe products based on gas chromatography/mass spectrometry (GC/MS) of the trimethyl silyl (TMS) derivatives of these analytes in the presence of Chrysophanol used as internal standard. The method ...

journal_title：International immunopharmacology

authors： ElSohly MA,Gul W,Murphy TP

更新日期：2004-12-20 00:00:00

abstract：:H1-antihistamines are known to be important modulators of inflammatory response. However, the information about the influence of these drugs on reactive nitrogen species generation is still controversial. The main aim of the present study was to investigate the effects of selected H1-antihistamines on nitric oxide pro...

journal_title：International immunopharmacology

authors： Králová J,Racková L,Pekarová M,Kubala L,Nosál R,Jancinová V,Cíz M,Lojek A

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Immunoglobulin A (IgA) nephropathy (IgAN) is a common primary glomerular disease that potentially leads to renal failure, risk prediction of declining kidney function is crucial for early clinical management. Immunoglobulin G (IgG) is an important constituent of the immune system and serves as the preferred ...

journal_title：International immunopharmacology

authors： Liu D,You J,Liu Y,Tang X,Tan X,Xia M,Wu L,Chen G,He L,Zhu X,Liu H

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND AIM:Rheumatoid arthritis treatment aims to control joint damage and any associated complications such as cardiovascular disease. Most anti-inflammatory drugs have a high tendency to cause gastro-intestinal irritation. The present study is designed to investigate the anti-inflammatory effect of carvedilol...

journal_title：International immunopharmacology

authors： Osman AS,Labib DA,Kamel MM

更新日期：2017-09-01 00:00:00

abstract：:Ampelopsin (AMP), a plant flavonoid, has potent anti-inflammatory properties in vitro and in vivo. The molecular mechanisms of ampelopsin on pharmacological and biochemical actions of RAW264.7 macrophages in inflammation have not been clearly elucidated yet. In the present study, non-cytotoxic level of ampelopsin sign...

journal_title：International immunopharmacology

authors： Qi S,Xin Y,Guo Y,Diao Y,Kou X,Luo L,Yin Z

更新日期：2012-01-01 00:00:00

abstract：:Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising trea...

journal_title：International immunopharmacology

authors： Tavakolpour S,Mahmoudi H,Balighi K,Abedini R,Daneshpazhooh M

更新日期：2018-01-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an autoimmune inflammatory and vascular disorder leading to progressive tissue fibrosis. Tanshinone IIA (Tan IIA) is a phytochemical extracted from the Chinese herb Salvia miltiorrhiza that exhibits diverse activities. In this study, we attempted to evaluate the potential impact of Tan IIA ...

journal_title：International immunopharmacology

authors： Jiang Y,Hu F,Li Q,Shen C,Yang J,Li M

更新日期：2019-12-01 00:00:00

abstract：:Metformin is a widely used anti-diabetic drug and increasing evidence suggests that metformin have profound cardioprotective effects under both diabetic and non-diabetic situations. The protective benefits of metformin have been proved in diabetic patients with cardiovascular complications and in experimental animals ...

journal_title：International immunopharmacology

authors： Liu G,Wu K,Zhang L,Dai J,Huang W,Lin L,Ge P,Luo F,Lei H

更新日期：2017-06-01 00:00:00

abstract：:The effect of melatonin on the expression of genes previously correlated to T lymphocyte activation (HLA-DRB, thymosin beta 10 (beta-Tim)) and to Lymphokine Activated Killer (LAK) activity (beta-Tim, Tumour Rejection Antigen (TRA 1), nRap 2) was investigated in phytohemagglutinin (PHA)-stimulated human lymphocyte cult...

journal_title：International immunopharmacology

authors： Capelli E,Campo I,Panelli S,Damiani G,Barbone MG,Lucchelli A,Cuccia M

更新日期：2002-06-01 00:00:00

abstract：:The RNA-binding protein tristetraprolin (TTP) is an adenine/uridine (AU)-rich elements (AREs)-binding protein that can induce the decay of AREs containing mRNAs. In this study, we demonstrated that TTP is significantly down-regulated in human glioma tissue samples and cell lines. It is also associated with diminished ...

journal_title：International immunopharmacology

authors： Zeng B,Zhu D,Su Z,Li Z,Yu Z

更新日期：2016-10-01 00:00:00

abstract：:High mobility group box protein 1 (HMGB1) and receptor for the advanced glycation end product (RAGE) play important roles in the development of sepsis-induced acute lung injury (ALI). Ketamine is considered to confer protective effects on ALI during sepsis. In this study, we investigated the effects of ketamine on HMG...

journal_title：International immunopharmacology

authors： Li K,Yang J,Han X

更新日期：2016-05-01 00:00:00

abstract：:Amaranthus spinosus Linn. (thorny amaranth), a plant that grows in the wild fields of Taiwan, is extensively used in Chinese traditional medicine to treat diabetes. There have been no published studies on the immunological effects of A. spinosus. To determine whether A. spinosus has immuno-modulatory effects and clari...

journal_title：International immunopharmacology

authors： Lin BF,Chiang BL,Lin JY

更新日期：2005-04-01 00:00:00

abstract：:Trans sodium crocetinate (TSC) has been reported to exert a protective effect against cerebral ischemia/reperfusion (I/R) injury. However, whether TSC protects against myocardial ischemia/reperfusion (MI/R) injury remains unknown. Herein, we found that TSC treatment reduced myocardial infract size and elevated serum L...

journal_title：International immunopharmacology

authors： Chang G,Chen Y,Zhang H,Zhou W

更新日期：2019-06-01 00:00:00

abstract：:Endotoxin, also known as lipopolysaccharide (LPS), is the major mediator of septic shock due to Gram-negative bacterial infections. Recently, much attention has been focused on cationic peptides which possess the potential to detoxify LPS. Limulus anti-LPS factor (LALF), a protein found in the horseshoe crab (Limulus ...

journal_title：International immunopharmacology

authors： Ren JD,Gu JS,Gao HF,Xia PY,Xiao GX

更新日期：2008-06-01 00:00:00

abstract：:Airway remodeling includes lung structural changes that have a role in the irreversibility of pulmonary dysfunction shown in chronic bronchial asthmatics. The current experiment investigated the effect of the mitochondrial antioxidant, tiron in comparison with dexamethasone (DEXA) on airway remodeling in chronic asthm...

journal_title：International immunopharmacology

authors： El-Sherbeeny NA,Hassan ZA,Ateyya H

更新日期：2016-10-01 00:00:00

abstract：:An emerging role is postulated for IL-17-producing thymocytes, which in their majority consist of IL-17-producing CD4(+) cells. For these, a specific role in the immediate defense against infectious pathogens is suggested, independent from the development of an adaptive immune response in the immune periphery. Immune ...

journal_title：International immunopharmacology

authors： Weber A,Zimmermann C,Mausberg AK,Kieseier BC,Hartung HP,Hofstetter HH

更新日期：2013-10-01 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure results in an increased percentage of CD11b(+) (Mac-1(+)) cells in the spleens of mice challenged with P815 tumor cells, coincident with a failure of the mice to generate allospecific CD8(+) CTL activity. Since CD11b(+)Gr-1(+) myeloid suppressor cells (MSC) have been...

journal_title：International immunopharmacology

authors： Choi JY,Oughton JA,Kerkvliet NI

更新日期：2003-04-01 00:00:00

abstract：:Experimental autoimmune encephalomylitis (EAE), an animal mode of multiple sclerosis (MS), was previously considered that be mediated by Th1 cells. However, a number of recent studies provided strong evidence that T helper cells that produce IL-17 play a dominant role in the pathogenesis of EAE. Curcumin (1,7-Bis 94-h...

journal_title：International immunopharmacology

authors： Xie L,Li XK,Funeshima-Fuji N,Kimura H,Matsumoto Y,Isaka Y,Takahara S

更新日期：2009-05-01 00:00:00

abstract：:Current evidence indicates that semicarbazide-sensitive amine oxidase (SSAO) substrates possess insulin-mimic effect, which was thought to play an anti-inflammatory role. The purpose of the present study was to determine whether SSAO substrates benzylamine (BZA) and methylamine (MA) attenuate inflammatory response ind...

journal_title：International immunopharmacology

authors： Lin Z,Li H,Luo H,Zhang Y,Luo W

更新日期：2011-08-01 00:00:00

abstract：:Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the intestinal tract. Baicalin, originally isolated from the root of the Chinese herb Huangqin (Scutellaria baicalensis Georgi) and its main active ingredient, has a protective effect against inflammatory responses in several diseases. The presen...

journal_title：International immunopharmacology

authors： Zhu W,Jin Z,Yu J,Liang J,Yang Q,Li F,Shi X,Zhu X,Zhang X

更新日期：2016-06-01 00:00:00

abstract：:The activities of dectin-1 and mannose receptors on phagocytosis of Candida albicans and the production of TNF-α by macrophages from mice pretreated for 3 days with extract of Artocarpus intergrifolia seeds (jack extract), Artin M or jacalin were studied. Macrophages from these mice were coincubated with C. albicans C...

journal_title：International immunopharmacology

authors： Loyola W,Custodio LA,Felipe I,Conchon-Costa I,Carvalho PG,Quirino GF,Silva LF,Gaziri LC

更新日期：2012-02-01 00:00:00

abstract：:There are few studies regarding the evaluation of the kinin system in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the plasma levels of high-molecular weight kininogen (HKg), low-molecular weight kininogen (LKg) and plasma kallikrein; the plasma activity of tissue kallikrein and kinina...

journal_title：International immunopharmacology

authors： Dellalibera-Joviliano R,Reis ML,Donadi EA

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:To investigate the effect of miR-200c/PAI-2 on macrophage polarization into M2-type TAMs in TNBC. METHODS AND MATERIALS:PAI-2 expression in MDA-MB-231con, MDA-MB-231miR-200ab and MDA-MB-231miR-200c breast cancer cells was evaluated by RT-PCR and immunofluorescence (IF), while the expression of the TAM marker F...

journal_title：International immunopharmacology

authors： Meng Z,Zhang R,Wang Y,Zhu G,Jin T,Li C,Zhang S

更新日期：2020-04-01 00:00:00

abstract：:Bone destruction associated with rheumatoid arthritis (RA) is mainly attributed to the abnormal activation of osteoclasts, which are terminally differentiated cells of monocyte/macrophage lineage that resorb bone matrix. Studies on the immune regulation of osteoclasts in RA have promoted the new research field of "ost...

journal_title：International immunopharmacology

authors： Okamoto K,Takayanagi H

更新日期：2011-05-01 00:00:00

abstract：:Many herbal products are now used as remedies to treat various infectious and non-infectious conditions. Even though the use of herbs and natural products is much more evident in the Eastern world, their use in Western cultures is continuously increasing. Although the immunomodulatory effects of some herbs have been e...

journal_title：International immunopharmacology

authors： Majdalawieh AF,Fayyad MW

更新日期：2015-09-01 00:00:00

abstract：:Autoimmune, lupus-prone MRL lpr/lpr mice were treated orally with oxo-quinoline-3-carboxamide (ABR-25757), a newly developed immunomodulator. Treatment was initiated in one set of experiment at the age of 10 weeks, before the onset of clinically apparent disease, and in another set at 15 weeks, after the development o...

journal_title：International immunopharmacology

authors： Carlsten H,Jonsson C,Bokarewa M,Svensson L,Tarkowski A

更新日期：2004-11-01 00:00:00

abstract：:In this study, we investigated the preventive effects of curcumin using dextran sulfate sodium (DSS)-induced colitis and the potential role of curcumin in regulation of anti-inflammation through S-nitrosylation. After curcumin treatment for 6days, the body weight and disease activity index of DSS-induced mice was alle...

journal_title：International immunopharmacology

authors： Kao NJ,Hu JY,Wu CS,Kong ZL

更新日期：2016-09-01 00:00:00

abstract：:Lung innate immune response plays an important role in the clearance of pathogens from lungs, however, profound activation of innate immune cells (alveolar macrophages or neutrophils) can lead to development of acute lung inflammation or injury by producing various pro-inflammatory molecules (IL-1, TNF-alpha and H2O2 ...

journal_title：International immunopharmacology

authors： Kumar V,Harjai K,Chhibber S

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:Human recombinant interferon beta (IFN-β) is one of the first line treatments for Relapsing-Remitting Multiple Sclerosis (RRMS). However, the production of neutralizing antibodies (NAb) can impair its function. The aim of this study was to investigate the production of neutralizing antibodies against Rebif...

journal_title：International immunopharmacology

authors： Shokrollahi Barough M,Ashtari F,Sadat Akhavi M,Asghari N,Mosayebi G,Mirmohammadkhani M,Kokhaei N,Bahraminia F,Ajami A,Kokhaei P

更新日期：2018-09-01 00:00:00

abstract：:Plant extracts have been widely evaluated for possible immunomodulatory properties. We have earlier reported that ethanolic extract of Boerhaavia diffusa root, a plant used in Indian traditional medicine, has significant immunomodulatory potential. B. diffusa hexane, chloroform and ethanol extracts, and two pure compo...

journal_title：International immunopharmacology

authors： Pandey R,Maurya R,Singh G,Sathiamoorthy B,Naik S

更新日期：2005-03-01 00:00:00