miR-200c/PAI-2 promotes the progression of triple negative breast cancer via M1/M2 polarization induction of macrophage.

abstract：:Glucocorticoids (GCs) have been considered to regulate immune cell systems through induction of apoptosis in thymocytes and mature peripheral-blood lymphocytes. Here we report that apoptosis induced by cortisol in mitogen-activated peripheral-blood mononuclear cells (PBMC) is suppressed by cortisone, an oxidized metab...

journal_title：International immunopharmacology

authors： Hirano T,Horigome A,Takatani M,Oka K

更新日期：2001-11-01 00:00:00

abstract：:Suitable and efficient treatments for Henoch-Schönlein purpura nephritis (HSPN) with proteinuria remains unclear. Whether steroids combined with immunosuppressive agents improves prognosis compared to steroid therapy alone also remains controversial. This study explored whether combined therapy reduces proteinuria in ...

journal_title：International immunopharmacology

authors： Yu Y,Chen J,Yin H,Deng Z,Xie Y,Yuan Q,Xu H,Liu S,Tao L,Peng Z

更新日期：2020-04-01 00:00:00

abstract：BACKGROUNDS:C1q tumor necrosis factor-related protein 9 (CTRP9) has been suggested to exert an atheroprotective effect by modulating the inflammation, foam cell formation, endothelia and smooth muscle cell function via Adenosine Monophosphate Activated Protein Kinase (AMPK) pathway. On the other hand, the NLR Family Py...

journal_title：International immunopharmacology

authors： Zhang H,Gong X,Ni S,Wang Y,Zhu L,Ji N

更新日期：2019-12-01 00:00:00

abstract：:Bone erosion is a central feature of rheumatoid arthritis (RA) that is characterized by the infiltration of the synovial lining by osteoclasts and lymphocytes. In the present study, swertiamarin a major secoiridoid glycoside was evaluated for anti-osteoclastogenic property to prevent bone erosion in Freund's complete ...

journal_title：International immunopharmacology

authors： Hairul-Islam MI,Saravanan S,Thirugnanasambantham K,Chellappandian M,Simon Durai Raj C,Karikalan K,Gabriel Paulraj M,Ignacimuthu S

更新日期：2017-12-01 00:00:00

abstract：:This study was aimed to introduce a novel algorithm for determining linear B- and T-cell epitopes from Crimean-Congo haemorrhagic fever virus (CCHFV) antigens. To this end, 387 approved B- and T-cell epitopes, as well as 331 non-epitope peptides from different serotypes of the virus were collected from IEDB database f...

journal_title：International immunopharmacology

authors： Nosrati M,Mohabatkar H,Behbahani M

更新日期：2020-01-01 00:00:00

abstract：:Hemorrhagic transformation (HT) is a common and serious complication following ischemic stroke, especially after tissue plasminogen activator (t-PA) thrombolysis, which is associated with increased mortality and disability. Due to the unknown mechanisms and targets of HT, there are no effective therapeutic drugs to de...

journal_title：International immunopharmacology

authors： Ma G,Pan Z,Kong L,Du G

更新日期：2021-01-01 00:00:00

abstract：:Caffeic acid phenethyl ester (CAPE), an the active component of propolis, is known to have anticarcinogenic, antiviral and various biological activities; however, the effect of CAPE on the immunomodulatory activity in vivo remains unknown. We have investigated the effect of CAPE on the immune system in female Balb/c m...

journal_title：International immunopharmacology

authors： Park JH,Lee JK,Kim HS,Chung ST,Eom JH,Kim KA,Chung SJ,Paik SY,Oh HY

更新日期：2004-03-01 00:00:00

abstract：:The immunomodulatory proteins present in garlic have recently been shown to be identical to the garlic lectins ASA I and ASA II [Clement F, Pramod SN, Venkatesh YP. Int. Immunopharmacol. 2010; 10: 316-324]. In this study, the stability of garlic lectins as a function of pH, temperature and denaturants has been examine...

journal_title：International immunopharmacology

authors： Clement F,Venkatesh YP

更新日期：2010-10-01 00:00:00

abstract：:A novel nicotinic acetylcholine (ACh) receptor (nAChR)-mediated transduction pathway, regulating keratinocyte function, has been elucidated in studies of secreted mammalian Ly6/urokinase plasminogen activator receptor-related protein (SLURP)-1 and -2. SLURPs are members of Ly6/neurotoxin superfamily (Ly6SF) of protein...

journal_title：International immunopharmacology

authors： Moriwaki Y,Takada K,Tsuji S,Kawashima K,Misawa H

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Development of agents that specifically kill cancer cells and simultaneously elicit antitumor immune response is a step forward in cancer therapy. In the present study, we investigated whether the administration of artemether contributes to the augmentation of antitumor immunity and the regression of tumor t...

journal_title：International immunopharmacology

authors： Farsam V,Hassan ZM,Zavaran-Hosseini A,Noori S,Mahdavi M,Ranjbar M

更新日期：2011-11-01 00:00:00

abstract：:Interleukin 17 (IL-17) is a proinflammatory cytokine that acts as an immune checkpoint for several autoimmune diseases. Therapeutic neutralizing antibodies that target this cytokine have demonstrated clinical efficacy in psoriasis. However, biologics have limitations such as their high cost and their lack of oral bioa...

journal_title：International immunopharmacology

authors： Álvarez-Coiradas E,Munteanu CR,Díaz-Sáez L,Pazos A,Huber KVM,Loza MI,Domínguez E

更新日期：2020-12-01 00:00:00

abstract：:Inflammation and oxidative stress play important roles in the progression of renal damage. The natural polyphenol naringenin is known to exert potent antioxidant and anti-inflammatory effects. In this study, we have investigated the effect of naringenin on kidney dysfunction, fibrosis, endoplasmic reticulum (ER) stres...

journal_title：International immunopharmacology

authors： Karuppagounder V,Arumugam S,Thandavarayan RA,Pitchaimani V,Sreedhar R,Afrin R,Harima M,Suzuki H,Suzuki K,Nakamura M,Ueno K,Watanabe K

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Endothelin 1 (EDN1) is a strong angiogenic and mitogenic factor, playing a key role in hypervascularization, thyroid follicle cell hyperplasia, and lymphocyte infiltration in the thyroid gland of patients with Graves' disease (GD). EDN1 induces angiogenesis and mitogenesis via endothelin receptor type A (EDNRA)...

journal_title：International immunopharmacology

authors： Aydın AF,Develi-İş S,Doğru-Abbasoğlu S,Vural P,Ozderya A,Karadağ B,Uysal M

更新日期：2014-01-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) has a multitude of biological activity and is associated with a number of inflammatory and immune diseases, including rheumatoid arthritis (RA). The increased serum levels of MIF in patients not only suggest this protein as a marker for disease progression, but also as a po...

journal_title：International immunopharmacology

authors： Li S,Zhang R,Li P,Yi W,Zhang Z,Chen S,Su S,Zhao L,Hu C

更新日期：2008-06-01 00:00:00

abstract：:The hepatoprotective effect of Gypsophila elegans isoorientin (GEI) was evaluated using a hepatic fibrosis model induced by CCl4 in rats. The results revealed that GEI significantly prevented CCl4-induced liver injury and fibrosis, as evidenced by the attenuation of histopathological changes, the decrease in serum ami...

journal_title：International immunopharmacology

authors： Lin X,Chen Y,Lv S,Tan S,Zhang S,Huang R,Zhuo L,Liang S,Lu Z,Huang Q

更新日期：2015-09-01 00:00:00

abstract：:Chèdiak-Higashi syndrome is a rare autosomal recessive disease that causes hypopigmentation, recurrent infections, mild coagulation defects and neurological problems. Beige mice carry a mutation in the lysosome trafficking regulator (LYST) gene and display some of the key characteristics of human Chèdiak-Higashi syndr...

journal_title：International immunopharmacology

authors： Kiyoi T,Liu S,Sahid MNA,Shudou M,Ogasawara M,Mogi M,Maeyama K

更新日期：2019-04-01 00:00:00

abstract：:Primary immune thrombocytopenia (ITP) is an autoimmune disease characterized by pathogenic immunoglobulin G (IgG) autoantibodies that bind to platelets, causing their phagocytic removal and leading to reductions in platelet number. The neonatal Fc receptor (FcRn) selectively salvages and recycles IgG, including pathog...

journal_title：International immunopharmacology

authors： Smith B,Christodoulou L,Clargo A,Eddleston A,Greenslade K,Lightwood D,Shock A,Tyson K,Brennan FR

更新日期：2019-01-01 00:00:00

abstract：:This study was conducted to investigate the protective roles of soy isoflavone in weaned pigs challenged with lipopolysaccharide (LPS). A total of 72 weaned piglets (14 days of age) were randomly allotted into either 0 (control group) or 40 mg/kg soy isoflavone (ISO) supplementation group. On days 7 and 14, half of th...

journal_title：International immunopharmacology

authors： Zhu C,Wu Y,Jiang Z,Zheng C,Wang L,Yang X,Ma X,Gao K,Hu Y

更新日期：2015-09-01 00:00:00

abstract：:Astilbin is a potential agent for autoimmune and inflammatory diseases and has a protective effect in mice with DSS-induced colitis. NK1.1- CD4+ NKG2D+ T cells are a subpopulation of regulatory T cells that produce TGF-β1 and IL-10. Whether astilbin directly promotes the induction of NK1.1- CD4+ NKG2D+ T cells and whe...

journal_title：International immunopharmacology

authors： Han S,Lin Z,Wen J,Wu K,Xu Y,Zhang Y,Lu G,Xiao W,Ding Y,Jia X,Deng B,Gong W

更新日期：2020-04-01 00:00:00

abstract：:To examine the mechanisms of diabetes-enhanced inflammation, ear inflammation was induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in streptozotocin (STZ)-injected diabetic and control mice. The inflammatory response was determined from ear thickness and histology. The mRNA expression of several inflammation-rela...

journal_title：International immunopharmacology

authors： Iba Y,Watanabe K,Ozaki K,Aozasa O,Ishizawa K,Matsuura T,Oyama H,Masukawa T

更新日期：2013-03-01 00:00:00

abstract：:Immune thrombocytopenic purpura associated with multiple myeloma is extremely rare. Here, we present the successful management of an elderly Japanese patient with multiple myeloma complicated by immune thrombocytopenia with low dose cepharanthine - a plant derived alkaloid. A 78-year-old male patient with IgGκ multipl...

journal_title：International immunopharmacology

authors： Tabata R,Tabata C,Tazoh A,Nagai T

更新日期：2012-07-01 00:00:00

abstract：:Our previous findings demonstrated that chlorophyllin (CHL) inhibits inducible nitric oxide gene expression in macrophages. In the present study, we show that CHL inhibited IL-1beta production and its mRNA expression in a lipopolysaccharide (LPS)-stimulated murine macrophage cell-line, RAW 264.7. The inhibitory effect...

journal_title：International immunopharmacology

authors： Yun CH,Jeon YJ,Yang Y,Ju HR,Han SH

更新日期：2006-02-01 00:00:00

abstract：:Cartilage degradation is one of the pathological changes of osteoarthritis (OA), and accumulating evidence suggests an excess of matrix metalloproteinases (MMPs) plays a role in this cartilage breakdown. Here, we investigated the effects of chlorogenic acid (CGA) on the mRNA and protein expression of MMPs in interleuk...

journal_title：International immunopharmacology

authors： Chen WP,Tang JL,Bao JP,Hu PF,Shi ZL,Wu LD

更新日期：2011-01-01 00:00:00

abstract：:Oridonin is a natural compound purified from Rabdosia rubescens that has remarkable anti-inflammatory and antitumor activities. Although oridonin has been used in traditional Chinese medicine for many years to treat inflammatory diseases, the underlying mechanisms of these activities are not well understood. In this p...

journal_title：International immunopharmacology

authors： Guo W,Zheng P,Zhang J,Ming L,Zhou C,Zhang S

更新日期：2013-12-01 00:00:00

abstract：:Dendritic cells (DCs) control immune responses and are central to the development of immune memory and tolerance. DCs initiate and orchestrate immune responses in a manner that depends on signals they receive from microbes and cellular environment. Although DCs consist mainly of bone marrow-derived and resident popula...

journal_title：International immunopharmacology

authors： Chen K,Wang JM,Yuan R,Yi X,Li L,Gong W,Yang T,Li L,Su S

更新日期：2016-05-01 00:00:00

abstract：:Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) refer to acute and progressive hypoxic respiratory failure caused by non-cardiogenic factors, which is a common condition occurring in critically ill patients with widespread pulmonary inflammation. Use of a single medication or target cannot treat A...

journal_title：International immunopharmacology

authors： Huang Z,Liu H,Zhang X,Wen G,Zhu C,Zhao Y,Niu W,Qin Y,Chen H,Bai C,Liu G

更新日期：2018-10-01 00:00:00

abstract：:Calea uniflora Less. (family Asteraceae), also named "arnica" and "erva-de-lagarto", is a native plant to the South and Southeast of Brazil. This species was used to treat rheumatism, respiratory diseases, and digestive problems in Brazilian folk medicine. In vitro studies have shown the important biological effects o...

journal_title：International immunopharmacology

authors： da Rosa JS,de Mello SV,Vicente G,Moon YJ,Daltoé FP,Lima TC,de Jesus Souza R,Biavatti MW,Fröde TS

更新日期：2017-01-01 00:00:00

abstract：:The global panic of the novel coronavirus disease 2019 (COVID-19) triggered by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent requirement for effective therapy. COVID-19 infection, especially in severely ill patients, is likely to be associated with immune dysregulation, promptin...

journal_title：International immunopharmacology

authors： Razmi M,Hashemi F,Gheytanchi E,Dehghan Manshadi M,Ghods R,Madjd Z

更新日期：2020-11-01 00:00:00

abstract：:Endomorphin-1 is a recently isolated endogenous opioid peptide, and potent and selective high affinity mu-opioid receptor agonist. We evaluate the role of endomorphin-1 on macrophage functions. Endomorphin-1 potentiated macrophage adhesion and the expression of adhesion molecule Mac-1 on macrophages. However, endomorp...

journal_title：International immunopharmacology

authors： Inui Y,Azuma Y,Ohura K

更新日期：2002-07-01 00:00:00

abstract：:Acute lung injury (ALI) is characterized by disruption of the alveolar-capillary membrane resulting in pulmonary edema and accumulation of associated proteinaceous alveolar exudate. Initiation of ALI upregulates tumor necrosis factor-α (TNF-α), which activates nuclear factor-kappa B (NF-κB) and mitogen-activated prote...

journal_title：International immunopharmacology

authors： Ko IG,Hwang JJ,Chang BS,Kim SH,Jin JJ,Hwang L,Kim CJ,Choi CW

更新日期：2020-06-01 00:00:00