Abstract：
:Cartilage degradation is one of the pathological changes of osteoarthritis (OA), and accumulating evidence suggests an excess of matrix metalloproteinases (MMPs) plays a role in this cartilage breakdown. Here, we investigated the effects of chlorogenic acid (CGA) on the mRNA and protein expression of MMPs in interleukin (IL)-1β-induced rabbit chondrocytes and evaluated the in vivo effects of CGA in experimental OA induced by anterior cruciate ligament transection (ACLT) in rabbits. Using quantitative real-time PCR and ELISA to investigate the expression levels of MMP-1, MMP-3, MMP-13, and tissue inhibitors of metalloproteinase-1(TIMP-1) in IL-1β-induced rabbit chondrocytes, we showed that CGA inhibits the expression of these MMPs while increasing TIMP-1 expression, at both the mRNA and protein levels. In addition, IL-1β-induced activation of nuclear factor kappa B (NF-κB) and the degradation of inhibitor of κB (IκB)-α were suppressed by CGA. In rabbits, CGA decreased cartilage degradation as assessed by morphological and histological analyses. The down-regulation of MMP-1, MMP-3, and MMP-13 expression and up-regulation of TIMP-1 expression were also detected in CGA-treated cartilage compared with vehicle-treated cartilage, confirming these findings in an in vivo model. Taken together, these findings indicate that CGA may be considered as a possible candidate agent in the treatment of OA.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Chen WP,Tang JL,Bao JP,Hu PF,Shi ZL,Wu LDdoi
10.1016/j.intimp.2010.09.021subject
Has Abstractpub_date
2011-01-01 00:00:00pages
23-8issue
1eissn
1567-5769issn
1878-1705pii
S1567-5769(10)00313-9journal_volume
11pub_type
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journal_title：International immunopharmacology
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pub_type： 杂志文章
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更新日期：2010-10-01 00:00:00
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journal_title：International immunopharmacology
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