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Tissue-resident dendritic cells and diseases involving dendritic cell malfunction.

Abstract：

:Dendritic cells (DCs) control immune responses and are central to the development of immune memory and tolerance. DCs initiate and orchestrate immune responses in a manner that depends on signals they receive from microbes and cellular environment. Although DCs consist mainly of bone marrow-derived and resident populations, a third tissue-derived population resides the spleen and lymph nodes (LNs), different subsets of tissue-derived DCs have been identified in the blood, spleen, lymph nodes, skin, lung, liver, gut and kidney to maintain the tolerance and control immune responses. Tissue-resident DCs express different receptors for microbe-associated molecular patterns (MAMPs) and damage-associated molecular patterns (DAMPs), which were activated to promote the production of pro- or anti-inflammatory cytokines. Malfunction of DCs contributes to diseases such as autoimmunity, allergy, and cancer. It is therefore important to update the knowledge about resident DC subsets and diseases associated with DC malfunction.

journal_name

Int Immunopharmacol

journal_title

International immunopharmacology

authors

Chen K,Wang JM,Yuan R,Yi X,Li L,Gong W,Yang T,Li L,Su S

doi

10.1016/j.intimp.2016.02.007

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

1-15

eissn

1567-5769

issn

1878-1705

pii

S1567-5769(16)30042-X

journal_volume

34

pub_type

杂志文章,评审

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