Low dose cepharanthine ameliorates immune thrombocytopenic purpura associated with multiple myeloma.

abstract：:1,25-dihydroxyvitaminD3 [1,25(OH)2D3] modulates both the innate and adaptive immunity in tuberculosis. We explored the effect of 1,25(OH)2D3 on cytolytic molecules like perforin, granulysin, and granzyme-B in T-cells and natural killer cells during M. tuberculosis (Mtb) infection. Peripheral blood mononuclear cells (P...

journal_title：International immunopharmacology

authors： Afsal K,Selvaraj P,Harishankar M

更新日期：2018-09-01 00:00:00

abstract：:Increasing evidence suggests that inflammation is related to the pathophysiology of depression. Curcumin (CUR), which is a natural component extracted from the rhizome of Curcuma longa, seems to be efficacious in depression treatment. Hence, the present study aims to explore whether the anti-depressive effect of curcu...

journal_title：International immunopharmacology

authors： Zhang WY,Guo YJ,Han WX,Yang MQ,Wen LP,Wang KY,Jiang P

更新日期：2019-02-01 00:00:00

abstract：:In the present study, possible role of phosphodiesterase 7 (PDE7) in development and function of cytotoxic T lymphocyte (CTL) was examined using ASB16165, a specific inhibitor for PDE7. ASB16165 inhibited generation of CTL activity in mixed lymphocyte reaction (MLR), in which splenocytes from C57BL/6N mice were stimul...

journal_title：International immunopharmacology

authors： Kadoshima-Yamaoka K,Murakawa M,Goto M,Tanaka Y,Inoue H,Murafuji H,Hayashi Y,Nagahira K,Miura K,Nakatsuka T,Chamoto K,Fukuda Y,Nishimura T

更新日期：2009-01-01 00:00:00

abstract：:Endometriosis is a condition characterized by the presence of endometrial tissues outside the uterus. Endometriotic stromal cells (ESCs) are known to undergo regeneration and are linked to the causation of endometriosis. Activation of stromal cells by local inflammatory cytokines is proposed to be one of the mechanism...

journal_title：International immunopharmacology

authors： Lyu D,Tang N,Wang J,Zhang Y,Chang J,Liu Z,Liu H

更新日期：2019-06-01 00:00:00

abstract：:Cellular and molecular events in vascular smooth muscle cells (VSMC) from Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were investigated. SHR-derived VSMC showed increased proliferative capacity and MAP kinase levels in comparison with WKY-derived VSMC. Flow cytometry analysis revealed that progre...

journal_title：International immunopharmacology

authors： Lee SJ,Kim WJ,Moon SK

更新日期：2009-07-01 00:00:00

abstract：:Immunotherapy is the only effective treatment for scorpion stings. However the efficiency of this treatment varies depending on the forms of the antibodies and route of administration used. The antibodies are mostly injected as F(ab )(2) fragments. In this study, we investigated damage to the heart and lung tissue and...

journal_title：International immunopharmacology

authors： Sami-Merah S,Hammoudi-Triki D,Martin-Eauclaire MF,Laraba-Djebari F

更新日期：2008-10-01 00:00:00

abstract：:Stephanoside E (STE) and its aglycone Stephanthraniline A (STA) isolated from the stems of Stephanotis mucronata (Blanco) Merr. were evaluated for their suppressive potentials on Th1 and Th2 immune responses in vitro, and the effects of the C-3 sugar chains on their activities were discussed. STE and STA significantly...

journal_title：International immunopharmacology

authors： Chen F,Ni Y,Ye Y,Sun H,Li X,Xu S

更新日期：2010-10-01 00:00:00

abstract：:Acute lung injury (ALI) is a common acute respiratory disease treated in the clinic. Intestinal microflora disorder affect lung diseases through the gut-lung axis. In this study, we explored the regulatory mechanism of the gut flora in the host defense against lipopolysaccharide (LPS)-induced ALI through the TLR4/NF-k...

journal_title：International immunopharmacology

authors： Tang J,Xu L,Zeng Y,Gong F

更新日期：2021-02-01 00:00:00

abstract：:Plasma osteopontin (OPN) levels are elevated in tuberculosis patients and may involve granuloma formation. New inhibitors using brefelamide, an aromatic amide isolated from Dictyostelium cellular slime molds that may inhibit OPN transcription in A549 cells at 1 μM concentration, were synthesized as compounds C, D, and...

journal_title：International immunopharmacology

authors： Bai G,Matsuba T,Kikuchi H,Chagan-Yasutan H,Motoda H,Ozuru R,Yamada O,Oshima Y,Hattori T

更新日期：2019-10-01 00:00:00

abstract：:Cyclosporine A (CsA) is the first immunosuppressant universally used in allotransplantation. However, it has been demonstrated that this drug produces side effects in several organs, particularly in the kidney and in the heart. Since the immunosuppressive therapy induces myocardial toxicity, the aim of this study was ...

journal_title：International immunopharmacology

authors： Bianchi R,Rodella L,Rezzani R

更新日期：2003-03-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is a late phase inflammatory mediator in many inflammatory diseases. Extracellular HMGB1 could bind to many membrane receptors to activate downstream signaling molecules and promote inflammation resulting in cell and tissue damage. In our previous work, we found cannabinoid receptor Ⅱ...

journal_title：International immunopharmacology

authors： Zhou H,Du R,Li G,Bai Z,Ma J,Mao C,Wang J,Gui H

更新日期：2020-01-01 00:00:00

abstract：:Glabridin has multiple pharmacological activities including anti-microbial, anti-atherosclerotic, anti-nephritic, anti-inflammatory and cardiovascular protective activities. In this study, we investigated the effect of glabridin on dendritic cells, which play an essential role in innate and adaptive immune responses. ...

journal_title：International immunopharmacology

authors： Kim JY,Kang JS,Kim HM,Ryu HS,Kim HS,Lee HK,Kim YJ,Hong JT,Kim Y,Han SB

更新日期：2010-10-01 00:00:00

abstract：:The activities of dectin-1 and mannose receptors on phagocytosis of Candida albicans and the production of TNF-α by macrophages from mice pretreated for 3 days with extract of Artocarpus intergrifolia seeds (jack extract), Artin M or jacalin were studied. Macrophages from these mice were coincubated with C. albicans C...

journal_title：International immunopharmacology

authors： Loyola W,Custodio LA,Felipe I,Conchon-Costa I,Carvalho PG,Quirino GF,Silva LF,Gaziri LC

更新日期：2012-02-01 00:00:00

abstract：:Dopamine (DA), an important neurotransmitter, has been reported to play a negative role in tumor progression. DA acts its role via dopamine receptors (DRs), which can be divided into five receptor subtypes (D1R-D5R). Among these receptor subtypes, D2R has been found to inhibit IGF-I-induced gastric cancer cell growth....

journal_title：International immunopharmacology

authors： Huang H,Wu K,Ma J,Du Y,Cao C,Nie Y

更新日期：2016-10-01 00:00:00

abstract：:Microglia-mediated neuroinflammation is an important contributor to the pathogenesis of neurodegenerative diseases. Inhibition of neuroinflammation has been proved to be effective in neurodegenerative diseases treatment. Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key mediator of endogenous inducible defen...

journal_title：International immunopharmacology

authors： Zheng Y,Zhu G,He J,Wang G,Li D,Zhang F

更新日期：2019-08-01 00:00:00

abstract：:In the course of a search for anti-neuroinflammatory metabolites from marine fungi, aurantiamide acetate (1) was isolated from marine-derived Aspergillus sp. as an anti-neuroinflammatory component. Compound 1 dose-dependently inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in BV2 microglial c...

journal_title：International immunopharmacology

authors： Yoon CS,Kim DC,Lee DS,Kim KS,Ko W,Sohn JH,Yim JH,Kim YC,Oh H

更新日期：2014-12-01 00:00:00

abstract：:Caffeic acid phenethyl ester (CAPE), an the active component of propolis, is known to have anticarcinogenic, antiviral and various biological activities; however, the effect of CAPE on the immunomodulatory activity in vivo remains unknown. We have investigated the effect of CAPE on the immune system in female Balb/c m...

journal_title：International immunopharmacology

authors： Park JH,Lee JK,Kim HS,Chung ST,Eom JH,Kim KA,Chung SJ,Paik SY,Oh HY

更新日期：2004-03-01 00:00:00

abstract：:The aim of this study was to evaluate the involvement of both B1 and B2 kinins receptors (B1R and B2R) in the fibroblast proliferation induced by the cytokine tumour necrosis factor (TNF) attempting to establish an in vitro model of wound healing. Murine fibroblasts L-929 were cultivated in 24 wells plaque until total...

journal_title：International immunopharmacology

authors： França AJVBDV,De Faveri R,Nunes R,Steimbach VMB,Santin JR,Quintão NLM

更新日期：2018-12-01 00:00:00

abstract：:To study the effects of Taishan Pinus massoniana pollen polysaccharides (TPPPS) on Bordetella avium outer membrane protein A (ompA) recombinant protein vaccine, ompA was expressed, confirmed by Western blotting and mixed with TPPPS. Female BALB/c mice were randomly divided into six groups (I-VI). Groups I, II, and III...

journal_title：International immunopharmacology

authors： Zhao X,Liang M,Yang P,Guo F,Pan D,Huang X,Li Y,Wu C,Qu T,Zhu R

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a familiar joint degenerative disease. Long non-coding RNAs (lncRNAs) play vital roles in the pathogenesis of OA. Nevertheless, the regulatory impacts of lncRNA highly up-regulated in liver cancer (lncRNA-HULC) on OA remain dimness. The study tried to probe the protective effect of HUL...

journal_title：International immunopharmacology

authors： Chu P,Wang Q,Wang Z,Gao C

更新日期：2019-07-01 00:00:00

abstract：:We had reported that in the ischemic heart, locally formed bradykinin (BK) and angiotensin II (Ang II) activate B2- and AT1-receptors on sympathetic nerve terminals (SNE), promoting reversal of the norepinephrine (NE) transporter in an outward direction (i.e., carrier-mediated NE release). Although both BK and Ang II ...

journal_title：International immunopharmacology

authors： Levi R,Silver RB,Mackins CJ,Seyedi N,Koyama M

更新日期：2002-12-01 00:00:00

abstract：:Neuroinflammation, characterized by the activation of microglia and astrocytes, is important in the pathogenesis of many neurological disorders, such as Alzheimer's disease. Nonsteroidal anti-inflammatory drugs (NSAIDs), a group of chemically heterogenous medications, are used widely in the treatment of inflammation. ...

journal_title：International immunopharmacology

authors： You M,Miao Z,Sienkiewicz O,Jiang X,Zhao X,Hu F

更新日期：2020-07-01 00:00:00

abstract：:In the pathogenesis of acute respiratory distress syndrome (ARDS), an increase in vascular endothelial permeability may trigger pulmonary edema and ultimately lead to respiratory failure. Endothelial glycocalyx damage is an important factor that causes an increase in vascular endothelial permeability. Berberine (BBR) ...

journal_title：International immunopharmacology

authors： Huang L,Zhang X,Ma X,Zhang D,Li D,Feng J,Pan X,Lü J,Wang X,Liu X

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Primary biliary cholangitis (PBC) is an autoimmune liver disease characterised by destruction of small intrahepatic bile ducts. Recent studies suggest that miRNAs play a critical role in the pathogenesis of liver diseases. However the role served by miRNAs in the pathogenesis of PBC is still not clear. METH...

journal_title：International immunopharmacology

authors： Song Y,Yang H,Jiang K,Wang BM,Lin R

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND AIM:Rheumatoid arthritis treatment aims to control joint damage and any associated complications such as cardiovascular disease. Most anti-inflammatory drugs have a high tendency to cause gastro-intestinal irritation. The present study is designed to investigate the anti-inflammatory effect of carvedilol...

journal_title：International immunopharmacology

authors： Osman AS,Labib DA,Kamel MM

更新日期：2017-09-01 00:00:00

abstract：:Inflammation is fundamental in osteoarthritis (OA) pathogenesis. Semaphorin 4A (Sema4A) has been implicated in immune-associated diseases, however, its role in OA remains unclear. In this study, we show that Sema4A is upregulated in knee OA articular cartilage as well as in chondrocytes exposed to IL-1β treatment in v...

journal_title：International immunopharmacology

authors： Zhang H,Wei Q,Xiang X,Zhou B,Chen J,Li J,Li Q,Xiong H,Liu F

更新日期：2019-04-01 00:00:00

abstract：:Dendritic cells (DCs) control immune responses and are central to the development of immune memory and tolerance. DCs initiate and orchestrate immune responses in a manner that depends on signals they receive from microbes and cellular environment. Although DCs consist mainly of bone marrow-derived and resident popula...

journal_title：International immunopharmacology

authors： Chen K,Wang JM,Yuan R,Yi X,Li L,Gong W,Yang T,Li L,Su S

更新日期：2016-05-01 00:00:00

abstract：:Endothelial cell (EC) activation and dysfunction have been linked to a wide variety of vascular inflammatory diseases. However, the role of microRNAs in EC activation and inflammation remains largely unknown. In this study, we found that miR-130b was significantly decreased in human umbilical vein endothelial cells (H...

journal_title：International immunopharmacology

authors： Wang P,Zhang X,Li F,Yuan K,Li M,Zhang J,Li B,Liang W

更新日期：2017-10-01 00:00:00

abstract：:Apoptotic pathways play an important role in Mycobacterium tuberculosis-infected macrophages. Sirt1 is a member of the deacetylase family that is known to promote apoptosis resistance in many mammalian cells. However, the apoptotic role of Sirt1 in the process of M. tuberculosis infection remains unclear. With the hel...

journal_title：International immunopharmacology

authors： Yang H,Chen J,Chen Y,Jiang Y,Ge B,Hong L

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Growing evidence points to the pivotal role of inflammation in the pathogenesis of diabetic kidney disease (DKD). However, as an inflammation-based prognostic score, the significance of platelet-to-lymphocyte ratio (PLR) in biopsy-proven DKD remains uncertain. Therefore, the current study aimed to evaluate t...

journal_title：International immunopharmacology

authors： Duan S,Sun L,Zhang C,Wu L,Nie G,Huang Z,Xing C,Zhang B,Yuan Y

更新日期：2021-01-29 00:00:00