Abstract:
:Acute lung injury (ALI) is a common acute respiratory disease treated in the clinic. Intestinal microflora disorder affect lung diseases through the gut-lung axis. In this study, we explored the regulatory mechanism of the gut flora in the host defense against lipopolysaccharide (LPS)-induced ALI through the TLR4/NF-kB pathway by constructing a gut microflora dysbiosis-model with antibiotic administration and reconstruction of the intestinal microecology. Then, high-throughput sequencing was performed, and the levels of secreted IgA (sIgA), β-defensins, and Muc2 were measured to assess the gut flora and mucosal barrier. The expression of TLR4, NF-kB, TNF-α, IL-1β, oxidative stress and the lung wet/dry (W/D) ratio were evaluated to assess lung damage. Hematoxylin and eosin (HE) staining was performed to evaluate the damage to the gut and lung tissues. Accordingly, gut microbiota imbalance may regulate the TLR4/NF-kB signaling pathway in the lung immune system, activating oxidative stress in the lung and mediating lung injury through the regulation of the gut barrier. However, fecal microbiota transplantation (FMT) impairs the activity of the TLR4/NF-kB signaling pathway in the lung and decreases oxidative stress in animals with ALI by restoring the gut microecology. CONCLUSIONS: Our results indicated the protective effect of gut flora in regulating immunity of LPS-induced ALI by modulating the TLR4/NF-kB signaling pathway which may induce inflammation and oxidative stress.
journal_name
Int Immunopharmacoljournal_title
International immunopharmacologyauthors
Tang J,Xu L,Zeng Y,Gong Fdoi
10.1016/j.intimp.2020.107272subject
Has Abstractpub_date
2021-02-01 00:00:00pages
107272eissn
1567-5769issn
1878-1705pii
S1567-5769(20)33739-5journal_volume
91pub_type
杂志文章abstract::Previously, we reported the immunosuppressive action of the aqueous extract of Kalanchoe pinnata (Kp) in mice. In the present study, we report on the protective effect of Kp in fatal anaphylactic shock, likewise a Th2-driven immunopathology, and the identification of its active component. Mice daily treated with oral ...
journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2008.07.006
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abstract::Ulcerative colitis is a chronic nonspecific inflammatory disease of unknown cause. The aim of this study was to evaluate the anti-inflammatory effect of tauroursodeoxycholate in 2, 4, 6-trinitrobenzenesulfonic acid-induced experimental colitis in mice. After the induction of colitis for 24h, the mice were administrate...
journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2016.04.037
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abstract::Azithromycin (AZM) is a macrolide antibiotic that exhibits anti-inflammatory activity aside from its antimicrobial effect, a feature that may ameliorate certain inflammatory disorders and prevent graft-versus-host disease in patients receiving stem cell transplantation. In the present study, we investigated the abilit...
journal_title:International immunopharmacology
pub_type: 杂志文章
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abstract:AIM:Due to the significant increase in the antimicrobial resistance of Acinetobacter baumannii (A. baumannii), new drugs to block the progression of infection are strongly needed. Epigallocatechin-3-gallate (EGCG), a major component of green tea, has exhibited potential activity against A. baumannii in vitro. The aim o...
journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2020.107346
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journal_title:International immunopharmacology
pub_type: 杂志文章,meta分析,评审
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abstract::Visfatin plays an important role in inflammatory and metabolic conditions. In this study, the effects of septic stress on the serum, white-adipose-tissue (WAT), and liver visfatin levels of male and female rats were examined. Both gonadally intact (sham) and ovariectomized (OVX) female rats were used in order to evalu...
journal_title:International immunopharmacology
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journal_title:International immunopharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.intimp.2015.11.013
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journal_title:International immunopharmacology
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2020.106678
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2016.09.027
更新日期:2016-11-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2018.10.001
更新日期:2018-12-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/s1567-5769(02)00136-4
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pub_type: 杂志文章,评审
doi:10.1016/j.intimp.2020.106305
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2006.03.010
更新日期:2006-08-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2016.04.010
更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.intimp.2019.05.033
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2019.105934
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journal_title:International immunopharmacology
pub_type: 杂志文章,评审
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2014.12.017
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2014.01.003
更新日期:2014-03-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章,评审
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2004.04.011
更新日期:2004-08-01 00:00:00
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2013.02.014
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2017.02.020
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pub_type: 杂志文章
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journal_title:International immunopharmacology
pub_type: 杂志文章
doi:10.1016/j.intimp.2017.03.002
更新日期:2017-06-01 00:00:00
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journal_title:International immunopharmacology
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doi:10.1016/j.intimp.2009.06.003
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