Icariin targets Nrf2 signaling to inhibit microglia-mediated neuroinflammation.

abstract：:This study was conducted to investigate the protective roles of soy isoflavone in weaned pigs challenged with lipopolysaccharide (LPS). A total of 72 weaned piglets (14 days of age) were randomly allotted into either 0 (control group) or 40 mg/kg soy isoflavone (ISO) supplementation group. On days 7 and 14, half of th...

journal_title：International immunopharmacology

authors： Zhu C,Wu Y,Jiang Z,Zheng C,Wang L,Yang X,Ma X,Gao K,Hu Y

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy, safety and tolerability of β-d-mannuronic acid (M2000) in the treatment of ankylosing spondylitis (AS). METHODS:The study was a 12-week randomized, double-blind, placebo-controlled, phase I/II clinical trial with 3 treatment arms: placebo, β-d-mannuronic acid and naproxen. Patients ...

journal_title：International immunopharmacology

authors： Fattahi MJ,Jamshidi AR,Mahmoudi M,Vojdanian M,Yekaninejad MS,Jafarnezhad-Ansariha F,Ahmadi H,Rehm BHA,Matsuo H,Cuzzocrea S,Hosseini M,Hashemi SN,Aghazadeh Z,Mirshafiey A

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:Total glucosides of paeony (TGP) have been confirmed to exert anti-inflammatory and hepatoprotective effects. Methotrexate (MTX) and Leflunomide (LEF) combination has a better efficacy in the treatment of active rheumatoid arthritis (RA), but hepatotoxicity was observed. In this study, we investigated the eff...

journal_title：International immunopharmacology

authors： Xiang N,Li XM,Zhang MJ,Zhao DB,Zhu P,Zuo XX,Yang M,Su Y,Li ZG,Chen Z,Li XP

更新日期：2015-09-01 00:00:00

abstract：:Pulmonary exposure of rodents to porcine pancreatic elastase (PPE) induces lesions that morphologically resemble human panacinar emphysema. However, there has been little work on the comprehensive analysis of this model. The present study was designed to extensively examine the biological effects of PPE on inflammatio...

journal_title：International immunopharmacology

authors： Inoue K,Koike E,Takano H

更新日期：2010-11-01 00:00:00

abstract：:Oridonin, the major terpene isolated from Rabdosia rubescens, has been used as dietary supplement. Recently, it has been known to exhibit anti-inflammatory effect. This study we employed an in vitro model of LPS-stimulated human gingival fibroblasts to investigate the anti-inflammatory effects and mechanism of oridoni...

journal_title：International immunopharmacology

authors： Yu T,Xie W,Sun Y

更新日期：2019-07-01 00:00:00

abstract：:In the pathogenesis of acute respiratory distress syndrome (ARDS), an increase in vascular endothelial permeability may trigger pulmonary edema and ultimately lead to respiratory failure. Endothelial glycocalyx damage is an important factor that causes an increase in vascular endothelial permeability. Berberine (BBR) ...

journal_title：International immunopharmacology

authors： Huang L,Zhang X,Ma X,Zhang D,Li D,Feng J,Pan X,Lü J,Wang X,Liu X

更新日期：2018-12-01 00:00:00

abstract：:The aim of this study was to evaluate the involvement of both B1 and B2 kinins receptors (B1R and B2R) in the fibroblast proliferation induced by the cytokine tumour necrosis factor (TNF) attempting to establish an in vitro model of wound healing. Murine fibroblasts L-929 were cultivated in 24 wells plaque until total...

journal_title：International immunopharmacology

authors： França AJVBDV,De Faveri R,Nunes R,Steimbach VMB,Santin JR,Quintão NLM

更新日期：2018-12-01 00:00:00

abstract：:New strategies that stimulate cell-mediated immunity (CMI) against tumors and inhibit regulatory T cells are needed to improve the outcome of cancer immunotherapy. The aim of this study was to enhance the anti-tumor immunity of gp96 vaccine through naloxone administration. Therefore, we used BALB/c mouse model of fibr...

journal_title：International immunopharmacology

authors： Molla Hassan AT,Hassan ZM,Moazzeni SM,Mostafaie A,Shahabi S,Ebtekar M,Hashemi SM

更新日期：2009-11-01 00:00:00

abstract：:Distinct effect of ent-Kaurene Diterpenoids from Isodon serra on abnormal proliferation of murine lymphocytes was examined with MTT assay and Flow Cytometry Analyses (FCAS). After choosing the most appropriate monomer from these Diterpenoids, we introduced mouse tumescence model to investigate whether it could impact ...

journal_title：International immunopharmacology

authors： Zhang Y,Liu J,Jia W,Zhao A,Li T

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Primary biliary cholangitis (PBC) is an autoimmune liver disease characterised by destruction of small intrahepatic bile ducts. Recent studies suggest that miRNAs play a critical role in the pathogenesis of liver diseases. However the role served by miRNAs in the pathogenesis of PBC is still not clear. METH...

journal_title：International immunopharmacology

authors： Song Y,Yang H,Jiang K,Wang BM,Lin R

更新日期：2018-11-01 00:00:00

abstract：:The plasma kallikrein/kinin system that consists of the proteins factor XII, prekallikrein, and high molecular weight kininogen was first recognized as a surface-activated coagulation system arising when blood or plasma interacts with artificial surfaces. Although surface-activated contact activation occurs in vivo wh...

journal_title：International immunopharmacology

authors： Schmaier AH

更新日期：2008-02-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a high morbidity and disability disease with numerous inflammatory cells infiltrating in interstitial of articular cartilages and bones. As the most abundant inflammatory cells, neutrophil has been reported that their apoptosis changed gradually in the circumstance of RA. Apoptosis, one mo...

journal_title：International immunopharmacology

authors： An Q,Yan W,Zhao Y,Yu K

更新日期：2018-12-01 00:00:00

abstract：:We assessed the effects of Zizyphus lotus L. (Desf.) polyphenols (ZLP) on T-cell signaling and proliferation. Our results showed that ZLP exerted no effect on the increases in intracellular free calcium concentrations, [Ca(2+)]i, in human Jurkat T-cells. However, ZLP modulated the thapsigargin-induced increases in [Ca...

journal_title：International immunopharmacology

authors： Abdoul-Azize S,Bendahmane M,Hichami A,Dramane G,Simonin AM,Benammar C,Sadou H,Akpona S,El Boustani ES,Khan NA

更新日期：2013-02-01 00:00:00

abstract：:Problem due to disc degeneration is frequently found in the aging population. However, severe pain and accompanying end plate inflammation is only found in a small subset of patients, who can be of a younger age than most people with severe disc degeneration, with no apparent cause. We hypothesized that deficiencies i...

journal_title：International immunopharmacology

authors： Xu C,Zhang M,Li K,Ni M,Bai Y,Zhang J,Song X,Wang J

更新日期：2019-05-01 00:00:00

abstract：:Ischemia-reperfusion injury is a common early event in kidney transplantation and contributes to a delay in organ function. Acute tubular necrosis, impaired kidney function and organ leukocyte infiltration are the major findings. The therapeutic potential of stem cells has been the focus of recent research as these ce...

journal_title：International immunopharmacology

authors： da Silva LB,Palma PV,Cury PM,Bueno V

更新日期：2007-12-15 00:00:00

abstract：:To study the intramolecular signal transduction, we performed single point and cassette mutations in transmembranal and intracellular regions of the bradykinin B2 receptor. We studied the influence of the two intramembranal Cys residues at positions 304 and 348, the role of Arg at position 177 in the highly conserved ...

journal_title：International immunopharmacology

authors： Mueller S,Liebmann C,Reissmann S

更新日期：2002-12-01 00:00:00

abstract：:An emerging role is postulated for IL-17-producing thymocytes, which in their majority consist of IL-17-producing CD4(+) cells. For these, a specific role in the immediate defense against infectious pathogens is suggested, independent from the development of an adaptive immune response in the immune periphery. Immune ...

journal_title：International immunopharmacology

authors： Weber A,Zimmermann C,Mausberg AK,Kieseier BC,Hartung HP,Hofstetter HH

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:To investigate the effect of miR-200c/PAI-2 on macrophage polarization into M2-type TAMs in TNBC. METHODS AND MATERIALS:PAI-2 expression in MDA-MB-231con, MDA-MB-231miR-200ab and MDA-MB-231miR-200c breast cancer cells was evaluated by RT-PCR and immunofluorescence (IF), while the expression of the TAM marker F...

journal_title：International immunopharmacology

authors： Meng Z,Zhang R,Wang Y,Zhu G,Jin T,Li C,Zhang S

更新日期：2020-04-01 00:00:00

abstract：:Interleukin 17 (IL-17) is a proinflammatory cytokine that acts as an immune checkpoint for several autoimmune diseases. Therapeutic neutralizing antibodies that target this cytokine have demonstrated clinical efficacy in psoriasis. However, biologics have limitations such as their high cost and their lack of oral bioa...

journal_title：International immunopharmacology

authors： Álvarez-Coiradas E,Munteanu CR,Díaz-Sáez L,Pazos A,Huber KVM,Loza MI,Domínguez E

更新日期：2020-12-01 00:00:00

abstract：:Hepatitis C virus (HCV) envelope E2 is a glycoprotein that are implicated in HCV infection by facilitating its entry and immune evasion, which in turn leads to hepatitis, hepatocellular carcinoma and other chronic liver diseases. It is reported that the HCV E2 stem region comprise a functional region for HCV entry; ho...

journal_title：International immunopharmacology

authors： Liu X,Chen N,Lin S,Liu M

更新日期：2016-01-01 00:00:00

abstract：:Previously it was shown that treatment with mycophenolate mofetil (MMF) attenuated renal inflammation and glomerular injury in a model of diabetes. However, the mechanism involved in the renoprotective effects of MMF in experimental diabetes has not been clearly delineated. Diabetes was induced by injection of strepto...

journal_title：International immunopharmacology

authors： Wu YG,Lin H,Qi XM,Wu GZ,Qian H,Zhao M,Shen JJ,Lin ST

更新日期：2006-03-01 00:00:00

abstract：:Glabridin has multiple pharmacological activities including anti-microbial, anti-atherosclerotic, anti-nephritic, anti-inflammatory and cardiovascular protective activities. In this study, we investigated the effect of glabridin on dendritic cells, which play an essential role in innate and adaptive immune responses. ...

journal_title：International immunopharmacology

authors： Kim JY,Kang JS,Kim HM,Ryu HS,Kim HS,Lee HK,Kim YJ,Hong JT,Kim Y,Han SB

更新日期：2010-10-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) has a multitude of biological activity and is associated with a number of inflammatory and immune diseases, including rheumatoid arthritis (RA). The increased serum levels of MIF in patients not only suggest this protein as a marker for disease progression, but also as a po...

journal_title：International immunopharmacology

authors： Li S,Zhang R,Li P,Yi W,Zhang Z,Chen S,Su S,Zhao L,Hu C

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:To illustrate the potential effects and mechanism of extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) on fibrosis in sclerodermatous chronic graft-versus-host-disease (cGVHD) models after allogeneic hematopoietic stem cell transplantation. METHODS:We first observed the therapeutic effects...

journal_title：International immunopharmacology

authors： Guo L,Lai P,Wang Y,Huang T,Chen X,Geng S,Huang X,Luo C,Wu S,Ling W,Huang L,Du X,Weng J

更新日期：2020-07-01 00:00:00

abstract：:Bariatric surgeries, including Roux-en-Y gastric bypass (RYGB) are currently the best treatment for obesity and obesity-related comorbidities, such as type 2 diabetes. However, the underlying mechanism of bariatric surgeries is not entirely understood. Further investigations are needed to improve the success rate and ...

journal_title：International immunopharmacology

authors： Dai X,Zhao W,Zhan J,Zeng S,Ran D,Zhang H,Song Z,Song KH,Wu L

更新日期：2017-02-01 00:00:00

abstract：:Butyrate has multiple protective effects in inflammation-related intestinal diseases. Previous studies have found that butyrate could inhibit inflammation in rheumatoid arthritis. Inflammation is a pivotal inducement in the degeneration progress of the intervertebral disc. The anti-inflammatory treatment has an appare...

journal_title：International immunopharmacology

authors： Jia J,Nie L,Liu Y

更新日期：2020-01-01 00:00:00

abstract：:Galectin-9 (Gal-9) is a β-galactoside-binding soluble lectin family member that exerts its primary biological functions via specific glycoconjugate interactions. Gal-9 expression is closely related to tumor occurrence, development, metastasis and prognosis. In transplant immunology, a high level of Gal-9 expression ha...

journal_title：International immunopharmacology

authors： Yin J,Li L,Wang C,Zhang Y

更新日期：2020-11-01 00:00:00

abstract：:Corneal epithelial erosion is one of the most common problems in clinical ophthalmology. Despite significant progress in understanding how the cornea heals, clinically available pharmacological therapies that can promote repair and prevent visual complications remain limited. We have recently demonstrated that the ace...

journal_title：International immunopharmacology

authors： Chernyavsky AI,Galitovskiy V,Grando SA

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Allergic rhinitis (AR) is characterized by a Th2 polarized immune response and soluble HLA (sHLA) molecules play an immunomodulatory role in this response. Previously, it has been reported that these molecules are increased in sera of patients with pollen-induced allergic rhinitis studied outside the pollen ...

journal_title：International immunopharmacology

authors： Ciprandi G,Contini P,Murdaca G,DeAmici M,Gallina AM,Puppo F

更新日期：2009-08-01 00:00:00

abstract：:Dietary ingredients can decrease the risk of a variety of human cancers. Quercetin (3,3',4',5,7-pentahydroxyflavone) has a long history of consumption as part of the normal human diet and is able to induce growth inhibition in multiple cancer cells. In an attempt to generate more potent therapeutic effect for breast c...

journal_title：International immunopharmacology

authors： Du G,Lin H,Yang Y,Zhang S,Wu X,Wang M,Ji L,Lu L,Yu L,Han G

更新日期：2010-07-01 00:00:00