Effects of Zizyphus lotus L. (Desf.) polyphenols on Jurkat cell signaling and proliferation.

abstract：:Understanding of oligodendrocyte precursor cells and their role in the generation of oligodendrocytes in developing and adult rodents has been considered, particularly much less is known about aged-rodent oligodendrocyte precursor cells and their cell lineage. In this present study, we have developed oligodendrocyte c...

journal_title：International immunopharmacology

authors： Kobayashi J,Seiwa C,Sakai T,Gotoh M,Komatsu Y,Yamamoto M,Fukutake M,Matsuno K,Sakurai Y,Kawano Y,Asou H

更新日期：2003-07-01 00:00:00

abstract：:Bothrops snake venoms contain biologically active components, including L-amino acid oxidases (LAAO) that induce significant leukocyte accumulation at inflammatory sites characterized by early neutrophil infiltration. As it remains unclear how snake venoms modulate neutrophil activation and chemokine production, here ...

journal_title：International immunopharmacology

authors： Pereira-Crott LS,Casare-Ogasawara TM,Ambrosio L,Chaim LFP,de Morais FR,Cintra ACO,Canicoba NC,Tucci LFF,Torqueti MR,Sampaio SV,Marzocchi-Machado CM,Castro FA

更新日期：2020-03-01 00:00:00

abstract：:In the present study, we investigated that (-)-aptosimon, isolated from flower buds of Daphne genkwa, inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide (NO) synthase (iNOS) expression in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Similarly, (-)-aptosimon suppressed tumor necrosis factor (TNF)-alph...

journal_title：International immunopharmacology

authors： Lee MY,Park BY,Kwon OK,Yuk JE,Oh SR,Kim HS,Lee HK,Ahn KS

更新日期：2009-07-01 00:00:00

abstract：:The abundantly available source of stem cells and the low incidence of graft-versus-host disease (GVHD) made cord blood an attractive alternative source of hematopoietic stem cells for transplantation. Besides T cell and NK cell, NKT cell played an important role in low incidence of GVHD during allogeneic transplantat...

journal_title：International immunopharmacology

authors： Wang Y,Zheng X,Wei H,Sun R,Tian Z

更新日期：2008-06-01 00:00:00

abstract：:Standing at the interface of innate and adaptive immune, γδ T cells play important pathophysiologic roles in infection, autoimmunity, and tumorigenesis. Recent studies indicate that γδ T cells could be categorized into IFN-γ(+) and IL-17(+) subsets, both of which possess select TCR usages, bear unique surface markers ...

journal_title：International immunopharmacology

authors： Hou L,Wang T,Sun J

更新日期：2015-10-01 00:00:00

abstract：:Cigarette smoking is highly associated with increased cardiovascular disease complications. The female population, however, manifests reduced cardiovascular morbidity. We define nicotine's effect upon human umbilical vein endothelial cells (HUVECs), determine whether estradiol might ameliorate endothelial dysfunction ...

journal_title：International immunopharmacology

authors： Wang LL,Zhao JL,Lau WB,Zhang YQ,Qiao ZD,Wang YJ

更新日期：2011-06-01 00:00:00

abstract：:Glucocorticoids (GCs) have been considered to regulate immune cell systems through induction of apoptosis in thymocytes and mature peripheral-blood lymphocytes. Here we report that apoptosis induced by cortisol in mitogen-activated peripheral-blood mononuclear cells (PBMC) is suppressed by cortisone, an oxidized metab...

journal_title：International immunopharmacology

authors： Hirano T,Horigome A,Takatani M,Oka K

更新日期：2001-11-01 00:00:00

abstract：:There is increasing appreciation of the critical pathogenic role of IL-17 in inflammation and autoimmune diseases, which could be produced from both adaptive Th17 cells and innate γδ T cells. Existing evidences suggest that IL-2 is important for in vivo accumulation of IL-17+ γδ T cells, leaving the mechanisms still e...

journal_title：International immunopharmacology

authors： Li T,Zhou Y,Sun X,Bian Y,Wang K,Guo Q,Wang Q,Qiu F

更新日期：2020-09-01 00:00:00

abstract：:MALT lymphoma-translocation protein 1 (Malt1) protease activity is triggered by stimulation of various immune receptors. Activation of Malt1 protease induces cleavage of negative regulators for immune responses, resulting in lymphocytes activation. Although Malt1 protease mediates the signaling process downstream of t...

journal_title：International immunopharmacology

authors： Nakamura Y,Yokoyama K,Igaki K,Tsuchimori N

更新日期：2018-03-01 00:00:00

abstract：:Recent experimental data suggest that immunity can be activated to prevent tumors. The rationale for prevention is strong because the setting is one endowed with an immune system that is neither impaired by tumor and treatment-induced suppression, nor tolerant to tumor-associated antigens. Oncogenic growth factor rece...

journal_title：International immunopharmacology

authors： Forni G,Curcio C,Spadaro M,Iliffe J,Quaglino E,Di Carlo E,Musiani P,Lollini PL

更新日期：2003-08-01 00:00:00

abstract：:Despite the use of increasingly specific immunosuppressive therapy, rejection remains the leading cause of death in cardiac transplant patients. Endomyocardial biopsy (EMB) is the gold standard for early detection and monitoring of cardiac transplant rejection. However, this approach is invasive and not suitable for r...

journal_title：International immunopharmacology

authors： Zupan I,Vrtovec B,Breskvar UD,Gabrijelcic T

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVE:Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes have been widely applied in disease therapies. However, the role of BMSCs-derived exosomes in depression remains obscure. This study aims to explore the mechanism of BMSCs-derived exosomal microRNA-26a (miR-26a) on hippocampal neuronal injury of depr...

journal_title：International immunopharmacology

authors： Guo H,Huang B,Wang Y,Zhang Y,Ma Q,Ren Y

更新日期：2020-02-20 00:00:00

abstract：:Previous studies demonstrated that annonaceous acetogenin (AA) was an antitumor drug with anti-angiogenic activity. However, the effect of AA on ocular neovascular disorders remains unclear. The aim of the present study is to explore the effect of AA092, an annonaceous acetogenin mimetic, on corneal neovascularization...

journal_title：International immunopharmacology

authors： Zhang J,Zhou H,Jiang S,Jin J,Li W,Wang W,Su SB

更新日期：2015-10-01 00:00:00

abstract：:Recently, immunotherapy has evolved into a true treatment modality with the approval of PD-1 and PD-L1 inhibitors as the standard care for first-line treatment in patients with non-small cell lung cancer (NSCLC). Until now, for patients with advanced NSCLC, treatment of targeting immune checkpoints reveals a promising...

journal_title：International immunopharmacology

authors： Zhang S,Bai X,Shan F

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND AIM:Rheumatoid arthritis treatment aims to control joint damage and any associated complications such as cardiovascular disease. Most anti-inflammatory drugs have a high tendency to cause gastro-intestinal irritation. The present study is designed to investigate the anti-inflammatory effect of carvedilol...

journal_title：International immunopharmacology

authors： Osman AS,Labib DA,Kamel MM

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Spontaneous abortion is a common disease in human pregnancy. Increasing evidence suggests that proper function of trophoblasts and immune balance of the maternal-fetal interface are crucial for successful pregnancy. Macrophages are involved in the maternal-fetal immune microenvironment. However, mechanisms a...

journal_title：International immunopharmacology

authors： Ying X,Jin X,Zhu Y,Liang M,Chang X,Zheng L

更新日期：2020-11-01 00:00:00

abstract：:Prenylated flavonoids are a unique class of naturally occurring flavonoids that have various pharmacological activities. In the present study, we investigated the anti-inflammatory effect in murine macrophages of a prenylated flavonoid, 10-oxomornigrol F (OMF), which was isolated from the twigs of Morus alba (Moraceae...

journal_title：International immunopharmacology

authors： Tran PL,Tran PT,Tran HNK,Lee S,Kim O,Min BS,Lee JH

更新日期：2018-02-01 00:00:00

abstract：:Macrophages are highly plastic cells. Depending on stimulation, macrophages rapidly polarize to functionally distinct phenotypes that are involved in the pathogenesis of inflammatory bowel disease (IBD). 1,25‑Dihydroxyvitamin D (1,25(OH)2D3) has immunomodulatory activity, and 1,25(OH)2D3 deficiency is correlated with ...

journal_title：International immunopharmacology

authors： Zhu X,Zhu Y,Li C,Yu J,Ren D,Qiu S,Nie Y,Yu X,Xu X,Zhu W

更新日期：2019-02-01 00:00:00

abstract：:Tuberculosis (TB) remains as a global health problem. The prevalence of this infection is related to the association with other diseases, such as HIV, neglect treatment and misuse of antibiotics. Hence, the identification of new drugs is required to eradicate TB. Possible alternatives to existing antibiotics include p...

journal_title：International immunopharmacology

authors： Guzmán-Beltrán S,Rubio-Badillo MÁ,Juárez E,Hernández-Sánchez F,Torres M

更新日期：2016-02-01 00:00:00

abstract：:Factor H is a 150 kDa single chain plasma glycoprotein that plays a pivotal role in the regulation of the alternative pathway of complement. Primary sequence analysis reveals a structural organization of this plasma protein, in 20 homologous units, called Short Consensus Repeats (SCRs), each about 60 amino acids long....

journal_title：International immunopharmacology

authors： Zipfel PF,Skerka C,Caprioli J,Manuelian T,Neumann HH,Noris M,Remuzzi G

更新日期：2001-03-01 00:00:00

abstract：:The purpose of this study was to prepare a tetravalent anti-human CD22 recombinant antibody with improved antitumor activity and a half life longer than that of its divalent counterpart. We compared the ability of tetravalent vs. divalent antibody to associate/dissociate to/from CD22-positive Daudi cells, to interact ...

journal_title：International immunopharmacology

authors： Liu XY,Pop LM,Roopenian DC,Ghetie V,Vitetta ES,Smallshaw JE

更新日期：2006-05-01 00:00:00

abstract：:Osteopontin (OPN) is a multifunctional extracellular matrix phosphoprotein that has a specific and complicated structure, and contributes to numerous physiological and pathological activities. The mechanism of OPN in many diseases has been confirmed; however, the role of OPN in myasthenia gravis (MG) remains unclear. ...

journal_title：International immunopharmacology

authors： Zhao J,Jing J,Zhao W,Li X,Hou L,Zheng C,Kong Q,Li W,Yao X,Chang L,Li H,Mu L,Wang G,Wang J

更新日期：2020-02-25 00:00:00

abstract：:Prostaglandin E2 (PGE2), a very potent lipid mediator produced from arachidonic acid (AA) through the action of cyclooxygenase (COX) enzymes, is implicated in the regulation of dendritic cell (DC) functions such as differentiation ability, cytokine-producing capacity, Th-cell polarizing ability, migration and maturati...

journal_title：International immunopharmacology

authors： Jia XY,Chang Y,Sun XJ,Dai X,Wei W

更新日期：2014-11-01 00:00:00

abstract：:Over-activation of microglia disrupts the physiological homeostasis of the brain, and induces inflammatory response and other processes which are implicated in neurodegenerative diseases. Therefore, theoretically, suppression of neuroinflammation would slow the progression of neurodegenerative disease. In this study, ...

journal_title：International immunopharmacology

authors： Bao Y,Chen Q,Xie Y,Tao Z,Jin K,Chen S,Bai Y,Yang J,Shan S

更新日期：2019-12-01 00:00:00

abstract：:Treatment of asthma with corticosteroids results in downregulation of eosinophilic airway inflammation. We evaluated in vitro the activity of an "inhaled" corticosteroid, mometasone furoate (MF), and of a "systemic" corticosteroid, dexamethasone (DEX), on eosinophil functions, i.e. adhesion molecule expression and cel...

journal_title：International immunopharmacology

authors： Sale R,Sabatini F,Silvestri M,Serpero L,Petecchia L,Rossi GA

更新日期：2004-12-15 00:00:00

abstract：BACKGROUND:Th17/Treg imbalance and the levels of related cytokines are essential in the pathogenesis of autoimmune and infectious diseases. The aim of the current study was to assess the Treg/Th17 balance and the levels of related cytokines associated with various degrees of liver injury in patients with chronic hepati...

journal_title：International immunopharmacology

authors： Liu B,Gao W,Zhang L,Wang J,Chen M,Peng M,Ren H,Hu P

更新日期：2017-05-01 00:00:00

abstract：:This study was aimed to investigate the anti-tumor and immunomodulatory activities of an exopolysaccharide (EPS) from Rhizopus nigricans. Our results showed EPS could significantly inhibit the tumor growth and increase the immune organs index of CT26 tumor-bearing mice. EPS treatment increased the productions of inter...

journal_title：International immunopharmacology

authors： Zhu L,Cao J,Chen G,Xu Y,Lu J,Fang F,Chen K

更新日期：2016-07-01 00:00:00

abstract：:Endometriosis is a gynecologic disorder characterized by the ectopic growth of misplaced endometrial cells. Moreover, immunological abnormalities of cell-mediated and humoral immunity may be associated with the pathogenesis of endometriosis. The effects of peritoneal fluid (PF) from endometriosis patients on the expre...

journal_title：International immunopharmacology

authors： Lee KS,Baek DW,Kim KH,Shin BS,Lee DH,Kim JW,Hong YS,Bae YS,Kwak JY

更新日期：2005-11-01 00:00:00

abstract：:Severe acute pancreatitis (SAP) is a severe clinical condition with significant morbidity and mortality. Multiple organs dysfunction (MOD) is the leading cause of SAP-related death. The over-release of pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α is the underlying mechanism of MOD; however, there is no ef...

journal_title：International immunopharmacology

authors： Cen Y,Liu C,Li X,Yan Z,Kuang M,Su Y,Pan X,Qin R,Liu X,Zheng J,Zhou H

更新日期：2016-09-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic immuno-inflammatory disease of the central nervous system characterized by demyelination and axonal damage. Cognitive changes are common in individuals with MS since inflammatory molecules secreted by microglia interfere with the physiological mechanisms of synaptic plasticity. Acc...

journal_title：International immunopharmacology

authors： Araújo SMDR,Duarte-Silva E,Marinho CGS,Oliveira WH,França MER,Lós D,Peron G,Tomaz L,Bonfanti AP,Verinaud L,Peixoto CA

更新日期：2020-08-01 00:00:00